Bisindolylmaleimide V
- CAS No.
- 113963-68-1
- Chemical Name:
- Bisindolylmaleimide V
- Synonyms
- RO 31-6045;BISINDOLYLMALEIMIDE V;Sotrastaurin Impurity 12;n-methylbis(indol-3-yl)maleimide;BisindolylMaleiMide V [Ro 31-6045];1-METHYL-3,4-BIS(3-INDOLYL)MALEIMIDE;1-METHYL-3,4-BIS(INDOL-3-YL)MALEIMIDE;2,3-Di(1H-Indol-3-yl)-N-methylmaleimide;2,3-BIS(1H-INDOL-3-YL)-N-METHYLMALEIMIDE;3,4-Di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione
- CBNumber:
- CB6329851
- Molecular Formula:
- C21H15N3O2
- Molecular Weight:
- 341.36
- MDL Number:
- MFCD00236433
- MOL File:
- 113963-68-1.mol
- MSDS File:
- SDS
| Melting point | >260 °C |
|---|---|
| Boiling point | 655.7±55.0 °C(Predicted) |
| Density | 1.450±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: soluble |
| form | solid |
| pka | 15.89±0.30(Predicted) |
| color | Orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 113963-68-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
Bisindolylmaleimide V price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 203303 | Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM). | 113963-68-1 | 400μG | $68.9 | 2023-01-07 | Buy |
| Sigma-Aldrich | 203303 | Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem | 113963-68-1 | 1mg | $223 | 2023-01-07 | Buy |
| Cayman Chemical | 13300 | Bisindolylmaleimide V ≥98% | 113963-68-1 | 1mg | $64 | 2024-03-01 | Buy |
| Cayman Chemical | 13300 | Bisindolylmaleimide V ≥98% | 113963-68-1 | 5mg | $280 | 2024-03-01 | Buy |
| Cayman Chemical | 13300 | Bisindolylmaleimide V ≥98% | 113963-68-1 | 10mg | $497 | 2024-03-01 | Buy |
Bisindolylmaleimide V Chemical Properties,Uses,Production
Description
Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4.
Definition
ChEBI: Ro 31-6045 is a member of indoles.
References
1) Marmy-Conus?et al.?(2002),?Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett.,?519?135 2) Harmon?et al.?(1997),?Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol.,?10?71 3) Toullec?et al.?(1991),?The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem.,?266?15771 4) Davis?et al. (1992),?Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem.,?35?177
Bisindolylmaleimide V Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |