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Urapidil hydrochloride

Urapidil hydrochloride structure

CAS No.: 64887-14-5

Chemical Name:: Urapidil hydrochloride

Synonyms: URAPIDIL HCL;Urapidil hydrochoride;URAPIDIL HYDROCHLORIDE;Eposin Etopophos Vepesid VP16;Urapidil hydrochloride USP/EP/BP;Urapidil HCl,Urapidil Hydrochloride;3-methyl-3-hydroxymethyloxyheterocyclobutane;URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG;6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE;6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride

CBNumber:: CB6332466

Molecular Formula:: C20H30ClN5O3

Molecular Weight:: 423.94

MDL Number:: MFCD00078601

MOL File:: 64887-14-5.mol

MSDS File:: SDS

Last updated:2024-04-18 11:58:16

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Urapidil hydrochloride Properties

Melting point	156-1580C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	H₂O: soluble
form	solid
color	white
Water Solubility	Soluble to 50 mM in water
InChI	InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
InChIKey	KTMLZVUAXJERAT-UHFFFAOYSA-N
SMILES	O(C1C=CC=CC=1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1)C.Cl
FDA UNII	PVU92PZO12

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

26-36

WGK Germany

RTECS

YQ9862000

NFPA 704

	0
2		0

Urapidil hydrochloride price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	U100	Urapidil hydrochloride solid	64887-14-5	100mg	$173	2023-06-20	Buy
Sigma-Aldrich	U100	Urapidil hydrochloride solid	64887-14-5	500mg	$691	2023-06-20	Buy
Alfa Aesar	J63219	Urapidil hydrochloride, 98+%	64887-14-5	1g	$191	2023-06-20	Buy
Alfa Aesar	J63219	Urapidil hydrochloride, 98+%	64887-14-5	5g	$605	2021-12-16	Buy
Cayman Chemical	29004	Urapidil (hydrochloride)	64887-14-5	250mg	$73	2024-03-01	Buy

Product number	Packaging	Price	Buy
U100	100mg	$173	Buy
U100	500mg	$691	Buy
J63219	1g	$191	Buy
J63219	5g	$605	Buy
29004	250mg	$73	Buy

Urapidil hydrochloride Chemical Properties,Uses,Production

Description

Urapidil is an antagonist of α₁-adrenergic receptors (α₁-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT_1A. It selectively binds to α₁- over α₂-ARs (IC₅₀s = 0.74 and 42 μM, respectively) and to 5-HT_1A over 5-HT_1B and 5-HT₂ receptors (IC₅₀s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT_1A receptors (EC₅₀ = 390 nM). It is also a β₁-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA₂ = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT_1A receptor antagonist spiroxatrine.

Chemical Properties

White to Off-White Crystalline Powder

Uses

Antihypertensive;Serotonergic receptor agonist

Uses

α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.

Uses

a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive

Biological Activity

α 1 -adrenoceptor antagonist and 5-HT 1A receptor agonist (pIC 50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

Side effects

Side effects that may occur during treatment with uradil antihypertension include dizziness, fatigue, nausea, and light-headedness effects. The increases in systolic blood pressure heart rate caused by three progressive work loads bicycle exercise were not affected during urapidil, A slight reduction in forced expiratory volume was observed in some patients during treatment with beta-blocker. There was no case orthostatic hypotension during urapidil administration, despite its alpha1-blocking action. Side-effects were rare negligible^[1].

References

[1] G LEONETTI. Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension.[J]. European Journal of Clinical Pharmacology, 1986, 30 6: 637-640. DOI:10.1007/BF00608208.

Urapidil hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Urapidil hydrochloride Suppliers

Global( 213)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei baicao biology science and technology co., ltd	+86-19131911055 +8617824879454	zhang@hbbocao.com	China	1035	58
Chengdu Aupone Pharmaceutical Co.Ltd.	+86-28-+86-28-87843998-6060-6060 +8618631098571	lijiaqi@aupone.com	China	43	58
Biopole Pharmatech Co., Ltd.	+8615151475053	biopole@163.com	China	37	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	246	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	7836	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58

Supplier	Advantage
Hebei baicao biology science and technology co., ltd	58
Chengdu Aupone Pharmaceutical Co.Ltd.	58
Biopole Pharmatech Co., Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
airuikechemical co., ltd.	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from Urapidil hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-18	Urapidil Hydrochloride 64887-14-5	US $50.00 / kg	1kg	99.912%	10ton	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-04-18	Urapidil hydrochloride 64887-14-5	US $50.00 / kg	1kg	99.10%	50000kg	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-04-18	Urapidil Hydrochloride 64887-14-5	US $30.00 / kg	1kg	99.7%	200000kg	Ouhuang Engineering Materials (Hubei) Co., Ltd

Urapidil Hydrochloride
64887-14-5
US $50.00 / kg
99.912%
Ouhuang Engineering Materials (Hubei) Co., Ltd

Urapidil hydrochloride
64887-14-5
US $50.00 / kg
99.10%
Ouhuang Engineering Materials (Hubei) Co., Ltd

Urapidil Hydrochloride
64887-14-5
US $30.00 / kg
99.7%
Ouhuang Engineering Materials (Hubei) Co., Ltd

Urapidil hydrochloride Spectrum

Urapidil hydrochloride(64887-14-5)¹HNMR

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1of4

6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE 6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE 6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE HYDROCHLORIDE URAPIDIL HYDROCHLORIDE URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione hydrochloride 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-quinone hydrochloride 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione,hydrochloride (1:1) 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride 2,4(1H,3H)-Pyrimidinedione,6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-,hydrochloride ( Urapidil hydrochloride USP/EP/BP Urapidil hydrochoride 3-methyl-3-hydroxymethyloxyheterocyclobutane 6-((3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrochloride Urapidil HCl,Urapidil Hydrochloride Eposin Etopophos Vepesid VP16 URAPIDIL HCL 64887-14-5 C20H30ClN5O3 C20H29N5O3HCl Adrenoceptor Intermediates & Fine Chemicals Pharmaceuticals 64887-14-5