NVS-PAK1-1
- CAS No.
- 1783816-74-9
- Chemical Name:
- NVS-PAK1-1
- Synonyms
- NVS-PAK1-1;NVS-PAK11Chemicalbook;NVS-PAK1-1 >=98% (HPLC);NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1;Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11;(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide;(S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide;1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-
- CBNumber:
- CB63333615
- Molecular Formula:
- C23H25ClF3N5O
- Molecular Weight:
- 479.93
- MDL Number:
- MFCD30723183
- MOL File:
- 1783816-74-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313 |
NVS-PAK1-1 price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1867 | NVS-PAK1-1 ≥98% (HPLC) | 1783816-74-9 | 5MG | $155 | 2023-06-20 | Buy |
Sigma-Aldrich | SML1867 | NVS-PAK1-1 ≥98% (HPLC) | 1783816-74-9 | 25MG | $618 | 2023-06-20 | Buy |
Cayman Chemical | 19964 | NVS-PAK1-1 ≥98% | 1783816-74-9 | 5mg | $121 | 2024-03-01 | Buy |
Cayman Chemical | 19964 | NVS-PAK1-1 ≥98% | 1783816-74-9 | 10mg | $218 | 2024-03-01 | Buy |
Cayman Chemical | 19964 | NVS-PAK1-1 ≥98% | 1783816-74-9 | 25mg | $481 | 2024-03-01 | Buy |
NVS-PAK1-1 Chemical Properties,Uses,Production
Uses
NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors.
Biochem/physiol Actions
NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc
storage
Store at -20°C
NVS-PAK1-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |
Chengdu Henghui Pharm Tec Co. Ltd. | 13540674322 15828370308 | CHINA | 121 | 55 | |
Chengdu Celes Technology Co., Ltd | 17323066073 | 2538834896@qq.com | China | 79 | 58 |
Deyang Sino Biotech. Co., LTD | +86-19182167371 +86-19182167371 | service@synlord.com | China | 96 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |