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Baloxavir marboxil

Description Pharmacokinetics Uses Contraindications Metabolism
Baloxavir marboxil
Baloxavir marboxil structure
CAS No.
1985606-14-1
Chemical Name:
Baloxavir marboxil
Synonyms
Xofluza;CS-2794;S-033188;S-033188;XOFLUZA;aloxavir marboxil;Baloxavir marboxil;Baoxavir Marboxdil;Baloxavir Impurity 9;PubChem ID: 124081896;baloxavir marboxil S-033188
CBNumber:
CB63361382
Molecular Formula:
C27H23F2N3O7S
Formula Weight:
571.55
MOL File:
1985606-14-1.mol

Baloxavir marboxil Properties

Boiling point:
712.8±70.0 °C(Predicted)
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pka
-1.46±0.40(Predicted)
FDA UNII
505CXM6OHG
NCI Drug Dictionary
baloxavir marboxil
ATC code
J05AX25

Baloxavir marboxil price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0030527 Baloxavirmarboxil 98.94% 1985606-14-1 5mg $90 2021-12-16 Buy
ChemScene CS-0030527 Baloxavirmarboxil 98.94% 1985606-14-1 10mg $150 2021-12-16 Buy
AK Scientific 4327EH Baloxavirmarboxil 1985606-14-1 25mg $151 2021-12-16 Buy
ChemScene CS-0030527 Baloxavirmarboxil 98.94% 1985606-14-1 25mg $280 2021-12-16 Buy
ChemScene CS-0030527 Baloxavirmarboxil 98.94% 1985606-14-1 50mg $450 2021-12-16 Buy

Baloxavir marboxil Chemical Properties,Uses,Production

Description

Baloxavir marboxil is an antiviral drug developed by Shionogi Co., a Japanese pharmaceutical company and Roche for the treatment of influenza A and influenza B infections. The drug was initially approved for use in Japan in February 2018 and approved by the FDA on October 24, 2018 for the treatment of acute uncomplicated influenza in patients 12 years of age and older who have been symptomatic for no more than 48 hours Label. Baloxavir marboxil, a cap-endonuclease inhibitor, has a unique mechanism of action when compared to the currently existing neuraminidase inhibitor drug class used to treat influenza infections.

Pharmacokinetics

Baloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease which prevents polymerase function and therefore influenza virus mRNA replication 5, 3. It has shown therapeutic activity against influenza A and B virus infections, including strains resistant to current antiviral agents 1. This drug inhibits an enzyme required for viral replication, thus rapidly treating flu virus infection 5, Label and alleviating the symptoms associated with infection. A single dose of this agent was shown to be superior to placebo in relieving influenza symptoms and superior to both oseltamivir and placebo drug in virologic outcomes (marked by decreased viral load).

Uses

Baloxavir marboxil is an influenza medication, an antiviral,that is taken as a single dose tablet,by mouth, by individuals that are 12 years of age or older,that have presented symptoms of this infection for no more than 48 hours.The efficacy of baloxavir marboxil administered after 48 hours has not been tested.

Contraindications

Baloxavir marboxil should not be co-administered with dairy products, calcium-fortified beverages, or laxatives, antacids, or oral supplements containing calcium, iron, magnesium, selenium, aluminum or zinc.

Metabolism

Baloxavir marboxil is a prodrug that is converted by hydrolysis to baloxavir, the active form that exerts anti-influenza virus activity Label.

Uses

Baloxavir Marboxil is a prodrug of S-033447, which is an inhibitor of the cap-dependent endonuclease of influenza A and B viruses.

Mechanism of action

Baloxavir marboxil is an influenza therapeutic agent, specifically, an enzyme inhibitor targeting the influenza virus' cap-dependent endonuclease activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as cap snatching, by which the virus derives short, capped primers from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral mRNAs. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's endonuclease activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir.

Side effects

Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir.

Baloxavir marboxil Preparation Products And Raw materials

Raw materials

Preparation Products


Baloxavir marboxil Suppliers

Global( 154)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Jinghao Pharmaceutical Co.,Ltd
+86-21-68900963
+86-21-68900963 sales@jinghaopharma.com CHINA 153 58
Hangzhou Huarong Pharm Co., Ltd.
+8613588754946 +86-571-86758373
0086-571-81131109 sales@huarongpharm.com CHINA 3149 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9010 55
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
+8619933070948
claire@hbyingong.com China 677 58
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897082
+86-531-58897093 ericqiao@jnchsd.com CHINA 158 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872
christine@shengqipharm.com CHINA 494 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
Shochem(Shanghai) Co.,Ltd
86-21-50800795
info@shochem.com CHINA 289 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14344 58

Related articles


View Lastest Price from Baloxavir marboxil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-14 Baloxavir marboxil
1985606-14-1
US $1.00 / g 10g 99.5% 1000kg Guangzhou Biocar Biotechnology Co.,Ltd.
2021-12-28 Baloxavir marboxil
1985606-14-1
US $180.00 / KG 10g 99% 500kg/month HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
2021-10-29 baloxavir marboxil
1985606-14-1
US $0.00 / ASSAYS 100ASSAYS 99.99% 10000 Jiangsu Monade Biological Technology Co., Ltd.

1985606-14-1(Baloxavir marboxil)Related Search:


  • CS-2794
  • S-033188
  • S-033188;XOFLUZA
  • Xofluza
  • aloxavir marboxil
  • PubChem ID: 124081896
  • Baloxavir marboxil
  • baloxavir marboxil S-033188
  • Baloxavir Impurity 9
  • (3R)-2-[(11S)-7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl]-9,12-dioxo-5-oxa-1,2,8-triazatricyclo[8.4.0.03,8]tetradeca-10,13-dien-11-yl]oxymethyl methyl carbonate
  • Carbonic acid, [[(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl]oxy]methyl methyl ester
  • Baloxavir marboxil fandachem
  • Baoxavir Marboxdil
  • N - [(s) - (2,3,4,5,6-pentafluorophenoxy) phenoxyphosphoryl] - L-alanine isopropyl ester (pentafluoroside chain)
  • Baloxavir marboxil (BXM, S033188)
  • 1985606-14-1
  • 985606-14-1
  • 1986605-59-1
  • C27H23F2N3O7S
  • API
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