2,2',4,4'-Tetrahydroxybenzophenone
- CAS No.
- 131-55-5
- Chemical Name:
- 2,2',4,4'-Tetrahydroxybenzophenone
- Synonyms
- BENZOPHENONE-2;Benzophenone, 2,2',4,4'-tetrahydroxy-;TETRAHYDROXYBENZOPHENONE;UV Absorber Benzophenone-2;2,2’,4,4’-tetrahydroxy-benzophenon;70A-196;uvinuld-50;Uvinul D-50;Uvinol D-50;Seesorb 106
- CBNumber:
- CB6344256
- Molecular Formula:
- C13H10O5
- Molecular Weight:
- 246.22
- MDL Number:
- MFCD00002278
- MOL File:
- 131-55-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2,2′,4,4′-Tetrahydroxybenzophenone 97% | T16403 | 25g | $68.5 |
| 2,2′,4,4′-Tetrahydroxybenzophenone 97% | T16403 | 100g | $148 |
| 2,2',4,4'-Tetrahydroxybenzophenone >98.0%(HPLC) | T0118 | 25g | $31 |
| 2,2′,4,4′-Tetrahydroxybenzophenone | T295900 | 100g | $110 |
| 2,2',4,4'-Tetrahydroxybenzophenone 99% | JK417769 | 100g | $135 |
| More product size | |||
| Melting point | 198-200 °C(lit.) |
|---|---|
| Boiling point | 349.21°C (rough estimate) |
| Density | 1.216 |
| refractive index | 1.4825 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Sonicated), Methanol (Slightly) |
| form | Solid |
| pka | 6.98±0.35(Predicted) |
| color | Needles from H2O |
| Water Solubility | Slightly soluble in water. |
| BRN | 1914746 |
| Stability | Hygroscopic |
| Cosmetics Ingredients Functions |
FRAGRANCE UV ABSORBER LIGHT STABILIZER |
| Cosmetic Ingredient Review (CIR) | 2,2',4,4'-Tetrahydroxybenzophenone (131-55-5) |
| InChI | 1S/C13H10O5/c14-7-1-3-9(11(16)5-7)13(18)10-4-2-8(15)6-12(10)17/h1-6,14-17H |
| InChIKey | WXNRYSGJLQFHBR-UHFFFAOYSA-N |
| SMILES | Oc1ccc(c(O)c1)C(=O)c2ccc(O)cc2O |
| LogP | 3.091 (est) |
| CAS DataBase Reference | 131-55-5(CAS DataBase Reference) |
| EWG's Food Scores | 4 |
| FDA UNII | PRR8K3H9VN |
| NIST Chemistry Reference | 2,2',4,4'-Tetrahydroxybenzophenone(131-55-5) |
| EPA Substance Registry System | 2,2',4,4'-Tetrahydroxybenzophenone (131-55-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H319 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DJ1892000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29145090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Sens. 1A |
|||||||||
| Hazardous Substances Data | 131-55-5(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 oral in rat: 1220mg/kg | |||||||||
| NFPA 704 |
|
2,2',4,4'-Tetrahydroxybenzophenone price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T16403 | 2,2′,4,4′-Tetrahydroxybenzophenone 97% | 131-55-5 | 25g | $68.5 | 2026-03-19 | Buy |
| Sigma-Aldrich | T16403 | 2,2′,4,4′-Tetrahydroxybenzophenone 97% | 131-55-5 | 100g | $148 | 2026-03-19 | Buy |
| TCI Chemical | T0118 | 2,2',4,4'-Tetrahydroxybenzophenone >98.0%(HPLC) | 131-55-5 | 25g | $31 | 2026-03-19 | Buy |
| TRC | T295900 | 2,2′,4,4′-Tetrahydroxybenzophenone | 131-55-5 | 100g | $110 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK417769 | 2,2',4,4'-Tetrahydroxybenzophenone 99% | 131-55-5 | 100g | $135 | 2021-12-16 | Buy |
2,2',4,4'-Tetrahydroxybenzophenone Chemical Properties,Uses,Production
Application
2,2',4,4'-Tetrahydroxybenzophenone (BZP-2) is water-soluble and light-yellow powder (figure 1). BZP-2 is widely used in perfumes to prevent their degradation due to light. BZP-2 is a UV-absorber that helps protect against product degradation because of UV-light exposure and it is widely used in sunscreens and in cosmetics (figure 2), such as: anti-aging” creams and hair sprays and shampoos, paints and plastics. It can also mask odor associated with a formulation’s composition. In addition, the hypolipemiant drug fenofibrate is also a substituted benzophenone.
Potential Exposure & Risk
Although 2,2',4,4'-Tetrahydroxybenzophenone is used as a UV-blocker in cosmetics, plastics and automotive car products, its safety issue still should be noted. Such as workers that use BZP-2 may breathe in dust or have direct skin contact and the general population may be exposed by dermal contact with products containing this compound.
Skin allergic reaction has been reported in some people using sunscreens or cosmetics containing this compound. 2,2',4,4'-Tetrahydroxybenzophenone(BZP-2) is a member of a group of chemicals known as endocrine disruptors, which may alter the function and/or development of the reproductive system. Limited evidence indicates that exposure to benzophenone UV-absorbing chemicals, including BZP-2, is associated with an altered ratio of males to females at birth (increased females).
Chemical Properties
yellow to brown crystalline powder
Uses
2,2',4,4'-Tetrahydroxybenzophenone is a uV-absorber that helps protect against product degradation because of uV-light exposure. It can also mask odor associated with a formulation’s composition.
Uses
2,2′,4,4′-Tetrahydroxybenzophenone are benzophenone-type UV filters with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation.
Uses
2,2',4,4'-Tetrahydroxybenzophenone is used as the raw material of ultraviolet absorbers in cosmetics, plastics, resins and rubber. It is used as pharmaceutical intermediates and light-sensitive materials. It is also used as pharmaceutical adjuvant.
Preparation
Obtained (small amount) by melting a fluorescin chloride/sodium hydroxide mixture in the presence of a very few water at 230–240° for 2–3 h.
Contact allergens
BZP-2 is widely used in perfumes to prevent their degradation due to light. It can cause allergic contact dermatitis.
Safety Profile
Moderately toxic by ingestion. Aneye irritant. Mutation data reported. When heated todecomposition it emits toxic fumes of NOx.
Synthesis
2 mol of resorcinol dimethyl ether is added dropwise to a mixture of 1 mol of phosgene and 1 mol of aluminum chloride, and the mixture is heated to 65-80° C at a temperature of 30-40° C in the presence of a chlorinated hydrocarbon selected from aliphatic and aromatic chlorides, such as ethylene dichloride. It is then cooled to 40° C, 2 to 3 mol of aluminum chloride are added, the mixture is heated to 60-70° C, dilute hydrochloric acid is treated with aqueous sodium hydroxide solution, and 2,2',4,4'-Tetrahydroxybenzophenone is isolated by filtration.
References
[1] Jisuk Bae . (2016). Couples’ urinary concentrations of benzophenone-type ultraviolet filters and the secondary sex ratio. Science of the Total Environment, 543, Pages 28-36. https://doi.org/10.1016/j.scitotenv.2015.11.019
2,2',4,4'-Tetrahydroxybenzophenone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046; | sales01@watsonbiotech.cn | China | 5735 | 58 |
| Jinan Qinmu Fine Chemical Co.,Ltd. | +8618660799346 | sales@qinmuchem.com | China | 1008 | 58 |
| QINGDAO JADE NEW MATERIAL TECNOLOGY CO.,LTD | +86-（+86-532）68077006 13658692156 | zandrew@jadenmtc.com | China | 222 | 58 |
| Qingdao Truelight functional Material Technology Co., Ltd. | +86-13573844393 | songjames@truelightchem.com | China | 222 | 58 |
| Wuhan Fortuna Chemical Co.,Ltd | +86-2759207851; +8618007136271 | hk@fortunachem.com | China | 6010 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
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View Lastest Price from 2,2',4,4'-Tetrahydroxybenzophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-26 | 2,2',4,4'-Tetrahydroxybenzophenone
131-55-5
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-04-25 | 2,2',4,4'-Tetrahydroxybenzophenone
131-55-5
|
US $5.00 / kg | 1kg | ≥99% | 500mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-04-25 | 2,2',4,4'-Tetrahydroxybenzophenone
131-55-5
|
US $0.00-0.00 / G | 0.1G | 99.99% | 2000000T | Anhuyan (Hainan) Biotechnology Co., LTD |
-
- 2,2',4,4'-Tetrahydroxybenzophenone
131-55-5
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 2,2',4,4'-Tetrahydroxybenzophenone
131-55-5
- US $5.00 / kg
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- 2,2',4,4'-Tetrahydroxybenzophenone
131-55-5
- US $0.00-0.00 / G
- 99.99%
- Anhuyan (Hainan) Biotechnology Co., LTD
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