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3-Hydroxy-N-methyl-3-phenyl-propylamine

3-Hydroxy-N-methyl-3-phenyl-propylamine structure

CAS No.: 42142-52-9

Chemical Name:: 3-Hydroxy-N-methyl-3-phenyl-propylamine

Synonyms: 3-(METHYLAMINO)-1-PHENYLPROPAN-1-OL;3-METHYLAMINO-1-PHENYLPROPANOL;N-METHYL-3-PHENYL-3-HYDROXYPROPYLAMINE;α-[2-(MethyL;Compound PDK0217;Atomoxetine EP Imp H;Atomoxetine USP RC A;Fluoxetine Impurity 1;Fluoxetine EP IMpurity A;Fluoxertine EP impurity A

CBNumber:: CB6345561

Molecular Formula:: C10H15NO

Molecular Weight:: 165.23

MDL Number:: MFCD00674078

MOL File:: 42142-52-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:25:22

Product description	Number	Pack Size	Price
Fluoxetine impurity A CRS, European Pharmacopoeia (EP) Reference Standard	Y0002201	15 mg	$180
Atomoxetine Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material	PHR2840	25MG	$665
α-[2-(Methylamino)ethyl]benzyl alcohol 97%	463477	1g	$36.2
Atomoxetine Related Compound A United States Pharmacopeia (USP) Reference Standard	1044470	10mg	$1290
Fluoxetine impurity A CRS, European Pharmacopoeia (EP) Reference Standard	Y0002201	Y0002201	$156
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3-Hydroxy-N-methyl-3-phenyl-propylamine Properties

Melting point	64 °C
Boiling point	170 °C / 31mmHg
Density	1.017±0.06 g/cm3(Predicted)
vapor pressure	0.037Pa at 25℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Soluble), Methanol (Slightly)
pka	14.24±0.20(Predicted)
form	Solid
color	Off-White to Pale Yellow
InChI	InChI=1S/C10H15NO/c1-11-8-7-10(12)9-5-3-2-4-6-9/h2-6,10-12H,7-8H2,1H3
InChIKey	XXSDCGNHLFVSET-UHFFFAOYSA-N
SMILES	C(C1C=CC=CC=1)(O)CCNC
LogP	0.98
CAS DataBase Reference	42142-52-9(CAS DataBase Reference)
FDA UNII	I28ND993BO
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

Safety Statements

36/37

WGK Germany

HS Code

2922199695

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	0
2		0

3-Hydroxy-N-methyl-3-phenyl-propylamine price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0002201	Fluoxetine impurity A CRS, European Pharmacopoeia (EP) Reference Standard	42142-52-9	15 mg	$180	2026-03-19	Buy
Sigma-Aldrich	PHR2840	Atomoxetine Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material	42142-52-9	25MG	$665	2026-03-19	Buy
Sigma-Aldrich	463477	α-[2-(Methylamino)ethyl]benzyl alcohol 97%	42142-52-9	1g	$36.2	2026-03-19	Buy
Sigma-Aldrich	1044470	Atomoxetine Related Compound A United States Pharmacopeia (USP) Reference Standard	42142-52-9	10mg	$1290	2026-03-19	Buy
Sigma-Aldrich	Y0002201	Fluoxetine impurity A CRS, European Pharmacopoeia (EP) Reference Standard	42142-52-9	Y0002201	$156	2024-03-01	Buy

Product number	Packaging	Price	Buy
Y0002201	15 mg	$180	Buy
PHR2840	25MG	$665	Buy
463477	1g	$36.2	Buy
1044470	10mg	$1290	Buy
Y0002201	Y0002201	$156	Buy

3-Hydroxy-N-methyl-3-phenyl-propylamine Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

3-Hydroxy-N-methyl-3-phenyl-propylamine is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.

Uses

α-[2-(Methylamino)ethyl]benzyl Alcohol (Fluoxetine EP Impurity A(Atomoxetine Related Compound A)) is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.This compound is found as an impurity in fluoxetine (F597100).

Synthesis

3-Hydroxy-N-methyl-3-phenyl-propylamine is one of important intermediate of preparation fluoxetine Hydrochloride. Up to now, the method for preparing N-methyl-3-phenyl-3-hydroxy-propylamine is mainly divided into three kinds; the first kind of be replace (halogen with 3-, dialkylamine, amido or ethoxycarbonyl) Propiophenone be starting raw material, earlier after reduction, the 1-phenylpropyl alcohol that 3-is replaced is converted into 3-Hydroxy-N-methyl-3-phenyl-propylamine again; Second kind and being: the different azoles alkane of 2-methyl-5-phenyl is carried out reductive ring open makes target compound; The third be: with getting the 1-phenylpropyl alcohol that 3-replaces behind epoxy styrene and the derivative reductive ring open thereof, be translated into target compound earlier.

References

[1] Patent: CN103992236, 2016, B. Location in patent: Paragraph 0051;0054; 0055
[2] Angewandte Chemie - International Edition, 2005, vol. 44, # 11, p. 1687 - 1689

3-Hydroxy-N-methyl-3-phenyl-propylamine synthesis

Synthesis of 3-Hydroxy-N-methyl-3-phenyl-propylamine from 3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE

3-Hydroxy-N-methyl-3-phenyl-propylamine Preparation Products And Raw materials

Raw materials

3-(METHYLAMINO)ACRYLOPHENONE 3-iodo-1-phenylpropan-1-ol 2-Methyl-5-phenylisoxazolidine 1-Propanone, 3-[methyl(phenylmethyl)amino]-1-phenyl- 3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE

3-(N-Benzyl-N-methylamino)propiophenone hydrochloride 3-CHLORO-1-PHENYL-1-PROPANOL Methylamine 3-Chloropropiophenone 1-Phenyl-2-propen-1-one

Cinnamaldehyde

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Preparation Products

Fluoxetine tert-butyl 3-hydroxy-3-phenylpropyl(methyl)carbamate

3-Hydroxy-N-methyl-3-phenyl-propylamine Suppliers

Global( 409)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019; +8615350851019	admin@86-ss.com	China	999	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21591	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29820	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2949	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from 3-Hydroxy-N-methyl-3-phenyl-propylamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-29	3-Hydroxy-N-methyl-3-phenyl-propylamine 42142-52-9			0.99		RongNa Biotechnology Co.,Ltd
2026-04-29	3-Hydroxy-N-methyl-3-phenyl-propylamine 42142-52-9	US $0.00 / Kg/Drum	1KG	99%min	1000KG	WUHAN FORTUNA CHEMICAL CO., LTD
2026-04-29	3-Hydroxy-N-methyl-3-phenyl-propylamine 42142-52-9	US $5.00 / kg	1kg	≥99%	50mt/year	Jinan Finer Chemical Co., Ltd

3-Hydroxy-N-methyl-3-phenyl-propylamine
42142-52-9
0.99
RongNa Biotechnology Co.,Ltd

3-Hydroxy-N-methyl-3-phenyl-propylamine
42142-52-9
US $0.00 / Kg/Drum
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

3-Hydroxy-N-methyl-3-phenyl-propylamine
42142-52-9
US $5.00 / kg
≥99%
Jinan Finer Chemical Co., Ltd

3-Hydroxy-N-methyl-3-phenyl-propylamine Spectrum

3-Hydroxy-N-methyl-3-phenyl-propylamine(42142-52-9)IR

42142-52-9(3-Hydroxy-N-methyl-3-phenyl-propylamine)Related Search:

Benzyl benzoate Methyl acrylate Ethyl acetate Trimethylamine Benzyl bromide

1-Propanol PHENYL VALERATE Ethylparaben Benzhydrylamine CHLOROPHOSPHONAZO III

Benzyl alcohol Methylparaben trimethylamine oxide 1-Phenyl-1-propanol Kresoxim-methyl

3-Phenyl-1-propanol Ethanol Flunixin Meglumin

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ALPHA-(2-METHYLAMINO)-ETHYLBENZENEMETHANOL ALPHA-[2-(METHYLAMINO)ETHYL]BENZYL ALCOHOL 3-HYDROXY-N-METHYL-3-PHENYLPROPYLAMINE 3-METHYLAMINO-1-PHENYL-1-PROPANOL N-METHYL-3-HYDROXY-3-PHENYL PROPYLAMINE (RS)-3-MethylaMino-1-Phenyl-Propan-1-ol 3-Hydroxy-N-Methyl-3-phenyl-propylaMin alpha-[2-(MethylaMino)ethyl]benzyl alcohol 97% A-[2-(Methylamino)Ethyl]Benzenemethanol 3-N-methyl-1-phenyl-propanol BENZENEMETHANOL,A-[2-(METHYLAMINO)ETHYL] 3-methylamino-1-phenylpropano α-[2-(Methylamino)ethyl]benzenemethanol N-Methyl-3-Phenyl-3-Hydroxypropylamin 3-Methylamino-1-phenylpropane-1-ol 3-Hydroxy-N-methyl-3-phenyl-pr α-[2-(methylamino)ethyl]benzyl alcohol 1-PHENYL-3-METHYLAMINO-1-PROPANOL PHENYL METHYL AMINO PROPANOL Propanol, 3-methylamino-1-phenyl Benzenemethanol, α-[2-(methylamino)ethyl]- Benzenemethanol, alpha-[2-(methylamino)ethyl]- 1-Phenyl-3-(methylamino)propane-1-ol N-Methyl-3-hydroxy-3-phenyl-1-propanamine N-Methyl-3-phenyl-3-hydroxypropylamine,97% N-Methyl 3-phenyl-3-hydroxy-1-propanaMine N-(3-Hydroxy-3-phenylpropyl)MethylaMine N-Methyl-N-(3-hydroxy-3-phenylpropyl)aMine 3-Hydroxy-N-methyl-3-phenylpropylamine 3-(Methylamino)-1-phenylpropanol Fluoxetine EP IMpurity A Methyl({3-[3-(2-Methylphenoxy)phenyl]propyl})aMine Fluoxertine EP impurity A -C (RS)-3-Methylamino-1-phenyl-1-propanol Fluoxertine EP impurity A 3-(methylamino)-1-phenylpropan-1-ol Oxalate Fluoxetine Impurity 1(EP-A) Atomoxetine Impurity 8(Atomoxetine EP Impurity H) Fluoxetine Hydrochloride Impurity Ⅰ：Fluoxetine EP Impurity A Fluoxetine Impurity 1 Atomoxetine EP Imp H 3-(Methylamino)-1-Phenyl-1-Ppropanol α-[2-(Methylamino)ethyl]benzylAlcohol> Fluoxetine EP Impurity A (Atomoxetine EP Impurity H) Atomoxetine USP RC A α-[2-(MethyL 3-Hydroxy-N-methyl-3-phenyl-propylamine USP/EP/BP Fluoxetine intermediate，3-Hydroxy-N-methyl-3-phenyl- propylamine Hydroxy-N-methyl-3-phenyl-propylamine ALPHA-[2-(METHYLAMINO)ETHYL]BENZYL Atomoxetine EP Impurity H/ Atomoxetine Related Compound A 3-Hydroxy-N-Methyl-3-Phenyl-Propylamine(42142-52-9) (1RS)-3-(Methylamino)-1-phenylpropan-1-ol Atomoxetine Related Compound A (3-(Methylamino)-1-phenylpropan-1-ol) (1044470) 3-METHYLAMINO-1-PHENYLPROPANOL 3-(METHYLAMINO)-1-PHENYLPROPAN-1-OL N-METHYL-3-PHENYL-3-HYDROXYPROPYLAMINE Compound PDK0217 Atomoxetine EP impurity H（Fluoxetine EP Impurity A）