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5-Fluorouridine

5-Fluorouridine Structure
5-Fluorouridine structure
CAS No.
316-46-1
Chemical Name:
5-Fluorouridine
Synonyms
FUR;5-FU;FURD;5-fur;5-FUrd;NSC 146604;NSC 519273;FLUOROURIDINE;5-FLUOROIDINE;5-fluoro-uridin
CBNumber:
CB6346346
Molecular Formula:
C9H11FN2O6
Molecular Weight:
262.19
MDL Number:
MFCD00036832
MOL File:
316-46-1.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:14
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5-Fluorouridine Properties

Melting point 182-184 °C
alpha 17 º (c=2, water 25 ºC)
Density 1.4200 (estimate)
refractive index 18 ° (C=1, H2O)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming)
form Powder
pka 7.63±0.10(Predicted)
color White
Water Solubility soluble
BRN 33662
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference 316-46-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 4K0M952561

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H341-H373
Precautionary statements  P201-P202-P260-P280-P308+P313-P405-P501-P501a
Hazard Codes  Xn,Xi
Risk Statements  40-68-36/37/38
Safety Statements  22-26-36/37-36/37/39-27-24/25
WGK Germany  3
RTECS  YU8050000
F  10
Hazard Note  Harmful
HS Code  29349990

5-Fluorouridine price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F5130 5-Fluorouridine proapoptotic anitproliferative plant growth regulator 316-46-1 100mg $124 2024-03-01 Buy
Sigma-Aldrich F5130 5-Fluorouridine proapoptotic anitproliferative plant growth regulator 316-46-1 1g $683 2024-03-01 Buy
TCI Chemical F0636 5-Fluorouridine >98.0%(T) 316-46-1 1g $50 2024-03-01 Buy
TCI Chemical F0636 5-Fluorouridine >98.0%(T) 316-46-1 5g $149 2024-03-01 Buy
Alfa Aesar J62083 5-Fluorouridine, 97% 316-46-1 1g $56.65 2024-03-01 Buy
Product number Packaging Price Buy
F5130 100mg $124 Buy
F5130 1g $683 Buy
F0636 1g $50 Buy
F0636 5g $149 Buy
J62083 1g $56.65 Buy

5-Fluorouridine Chemical Properties,Uses,Production

Description

5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1? Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.

Chemical Properties

White Powder

Uses

5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.

Uses

Antihypertensive

Uses

5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750).

Definition

ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.

General Description

5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.

Biochem/physiol Actions

5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

Purification Methods

5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]

References

1) Yen et al. (2006), Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries; RNA, 12 797 2) Schmittgen et al. (2005), Diverse gene expression pattern during 5-fluorouridine-induced apoptosis; Int. J. Oncol., 27 297

5-Fluorouridine Preparation Products And Raw materials

Raw materials

Preparation Products

5-Fluorouridine Suppliers

Global( 222)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 906 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Nanjing Baifuli Technology Co., Ltd. 		+86-15335185688 sales@unisyn.cn CHINA 332 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10828 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Shanghai Arbor Chemical Co., Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Nanjing Baifuli Technology Co., Ltd. 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from 5-Fluorouridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Fluorouridine pictures 2023-03-17 5-Fluorouridine
316-46-1
 US $54.00 / kg 1kg 99% 1000kg Hebei Duling International Trade Co. LTD
5-Fluorouridine pictures 2021-07-02 5-Fluorouridine
316-46-1
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
5-Fluorouridine pictures 2020-01-08 5-Fluorouridine
316-46-1
 US $2.00 / KG 1KG 98% 100g , 1kg, 5kg , 50kg Career Henan Chemical Co
  • 5-Fluorouridine pictures
  • 5-Fluorouridine
    316-46-1
  • US $54.00 / kg
  • 99%
  • Hebei Duling International Trade Co. LTD
  • 5-Fluorouridine pictures
  • 5-Fluorouridine
    316-46-1
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

5-Fluorouridine Spectrum

5-Fluorouridine(316-46-1)MS5-Fluorouridine(316-46-1)1HNMR5-Fluorouridine(316-46-1)IR15-Fluorouridine(316-46-1)IR25-Fluorouridine(316-46-1)Raman

316-46-1(5-Fluorouridine )Related Search:

5-Fluorouracil 5-Fluorouridine Floxuridine 2'-DEOXY-2'-FLUOROURIDINE,2''-DEOXY-2''-FLUOROURIDINE (2''-FLUORO-2''- DEOXYURIDINE) 5'-DEOXY-5-FLUOROURIDINE
DMT-2′Fluoro-dU Phosphoramidite Uracil 5-Fluoropyrimidine 5'-Deoxy-2',3'-O-isopropylidene-5-fluorouridine 2',3'-DIDEOXY-3'-FLUOROURIDINE
5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine 2'-DEOXY-5-FLUOROURIDINE, [3H]- 3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE 2',3'-dideoxy-5-fluorouridine 5-Fluorouridine
2'-Deoxy-5-fluorouridine 3',5'-dioctanoate 2'-Deoxy-5-fluorouridine 3',5'-dibutanoate 5'-O-(9-Octadecenoyl)-5-fluorouridine

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1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1 5-fluoro-uridin 5-fur Uridine, 5-fluoro- FURD FLUOROURIDINE 1-(3,4-DIHYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-FLUORO-1H-PYRIMIDINE-2,4-DIONE 5-FLUORO-1-(BETA-D-RIBOFURANOSYL)URACIL 5-FU 5-FLUOROURACIL-1BETA-D-RIBOFURANOSIDE 2,4-DIHYDROXY-5-FLUORO-1-BETA-D-RIBOFURANOSYLPYRIMIDINE 5-fluorouracil 1β-d-ribofuranoside 5-Fluorouridine97% 5-FLUOROURIDINE, 98+% 5-Fluorouridine 5-FLUOROIDINE (2'R,3'R,4'S,5'R)-1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione 1-(beta-D-Ribofuranosyl)-5-fluorouracil 5-FLUOROURIDINE extrapure 5-Fluorouracil 1β-D-ribofuranoside, FUrd 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione 5-FLUOROURIDINE, 99+% FUR 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-fluoropyriMidine-2,4(1H,3H)-dione 5-FUrd NSC 146604 NSC 519273 FUrd 1-(beta-D-Ribofuranosyl)-5-fluorouracil 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3 5-Fluorouridine> 5-Fluorouridine USP/EP/BP 5-Fluorouridine (5-FUrd) extrapure, 98% 1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-fluoropyrimidine-2,4-dione 5-Fluorouridine, impurity of 5-fluorouracil 5- fluorouracil nucleoside 316-46-1 C9H11FN2O6 Analytical Chromatography Product Catalog Alphabetic BioChemical Analytical Standards Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs FA - FL Fluorine series Biochemistry Chemical Reagents for Pharmacology Research Nucleosides and their analogs Nucleosides, Nucleotides & Related Reagents Bases & Related Reagents Nucleotides Nucleotides and Nucleosides Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals Pyrimidine Pyridines, Pyrimidines, Purines and Pteredines bc0001