2,5-Dimethoxybenzaldehyde
- CAS No.
- 93-02-7
- Chemical Name:
- 2,5-Dimethoxybenzaldehyde
- Synonyms
- Benzaldehyde, 2,5-dimethoxy-;34007;93-02--7;Benzaldehyde CRS;2,5-DiMethoxybenzaldehyde, 97% 25GR;NSC 6315;AKOS BBS-00003162;2,5-DimethoxybenzaL;2,5-Dimethoxybenzald;5-DiMethoxy benzaldehyde
- CBNumber:
- CB6348890
- Molecular Formula:
- C9H10O3
- Molecular Weight:
- 166.17
- MDL Number:
- MFCD00003314
- MOL File:
- 93-02-7.mol
Melting point | 46-48 °C (lit.) |
---|---|
Boiling point | 146 °C/10 mmHg (lit.) |
Density | 1.1708 (rough estimate) |
refractive index | 1.5260 (estimate) |
Flash point | >230 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | 795mg/l |
form | Crystalline Powder, Crystals and/or Chunks |
color | Yellow to beige |
Water Solubility | Soluble in chloroform and methanol. Slightly soluble in water. |
Sensitive | Air Sensitive |
BRN | 509301 |
InChIKey | AFUKNJHPZAVHGQ-UHFFFAOYSA-N |
LogP | 1.910 |
CAS DataBase Reference | 93-02-7(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | W49S1PPL78 |
NIST Chemistry Reference | Benzaldehyde, 2,5-dimethoxy-(93-02-7) |
EPA Substance Registry System | Benzaldehyde, 2,5-dimethoxy- (93-02-7) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08 |
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Signal word | Danger | |||||||||
Hazard statements | H315-H319-H334-H335 | |||||||||
Precautionary statements | P261-P264-P271-P302+P352-P304+P340+P312-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38-43 | |||||||||
Safety Statements | 26-36/37/39-24/25-36 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | CU5740500 | |||||||||
Hazard Note | Irritant | |||||||||
TSCA | Yes | |||||||||
HS Code | 29124900 | |||||||||
NFPA 704 |
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2,5-Dimethoxybenzaldehyde price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | D130605 | 2,5-Dimethoxybenzaldehyde 99% | 93-02-7 | 25g | $52.4 | 2024-03-01 | Buy |
Sigma-Aldrich | D130605 | 2,5-Dimethoxybenzaldehyde 99% | 93-02-7 | 100g | $118 | 2024-03-01 | Buy |
TCI Chemical | D1111 | 2,5-Dimethoxybenzaldehyde >97.0%(GC) | 93-02-7 | 25g | $63 | 2024-03-01 | Buy |
TCI Chemical | D1111 | 2,5-Dimethoxybenzaldehyde >97.0%(GC) | 93-02-7 | 250g | $389 | 2021-12-16 | Buy |
Alfa Aesar | A19928 | 2,5-Dimethoxybenzaldehyde, 98+% | 93-02-7 | 25g | $28 | 2024-03-01 | Buy |
2,5-Dimethoxybenzaldehyde Chemical Properties,Uses,Production
Chemical Properties
yellow crystalline solid
Uses
2,5-Dimethoxybenzaldehyde is used in the preparation of 2,5-dimethoxyphenethylamine, which is utilized to prepare psychoactive drugs such as 2,5-dimethoxy-4-bromophenethylamine, 2,5-dimethoxy-4-iodophenethylamine and 4-Chloro-2,5-dimethoxy-phenethylamine. It acts as an intermediate in organic synthesis.
Application
2,5-Dimethoxybenzaldehyde, also known as 2C-H, is an organic compound and a benzaldehyde derivative. It can be used to produce 2,5-dimethoxyphenethylamine. 2C-H is also used to produce many other substituted phenethylamines such as 2C-B, 2C-I and 2C-C.
Preparation
2,5-Dimethoxybenzaldehyde synthesis: Anethole is oxidized to anisaldehyde , which after isolation is subjected to a BaeyerVilliger oxidation reaction with performic or peracetic acid. The O-formyl-4-methoxyphenol obtained this way is hydrolyzed . 4-Methoxyphenol is subsequently formylated using the Reimer-Tiemann method and the obtained 2-hydroxy-5-methoxybenzaldehyde is methylated with dimethylsulfate to 2,5-dimethoxybenzaldehyde.
Reaction
A : Anisaldehyde from anethole via oxidative cleavage: 20 g anise oil was suspended in a mixture of 150 mL water and 30 mL conc. sulfuric acid; addition of 55 g sodium bichromate at such a rate that the temperature did not exceed 40°C. The reaction mixture was extracted with 4 x 125 mL toluene and the solvent evaporated. The residual oil was vacuum distilled to yield 9.1 g anisaldehyde.
B : O-formyl-4-methoxyphenol: 6 mL anisaldehyde was dissolved in 75 mL dichloromethane (DCM). A mixture of 12 g hydrogen peroxide and 10 mL conc. formic acid was added over 30 min. The reaction mixture was gently refluxed for 21 h.
C: B 4-methoxyphenol: Evaporating the solvent from reaction mixture and taking up the residue in 100 mL aqueous NaOH (20%) (25 mL MeOH as co-solvent) yielded 4.1 g 4-methoxyphenol as a white crystalline product after the usual work-up and purification steps.
D : Reimer-Tiemann formylation of 4-methoxyphenol: 124.1 g 4-methoxyphenol was dissolved in NaOH solution (320 g NaOH in 400 mL water). In total, 161 mL chloroform was added. The usual work-up and steam distillation yielded 109.8 g of a clear yellow oil that did not solidify upon standing at room temperature (GC/MS: 94% 2-hydroxy-5-methoxybenzaldehyde).
E: D Methylation of 2-hydroxy-5-methoxybenzaldehyde: The yellow oil from was used without further purification. A 250 mL RB flask was charged with 100 mL acetone, 14 g anhydrous potassium carbonate and 10 g 2-hydroxy-5-methoxybenzaldehyde; the mixture was brought at reflux temperature and 11 g dimethyl sulfate was added. The reaction was continued for 4 hours. The solvent is evaporated and the crude end product crystallized in cold water. Recrystallization from EtOH/water yielded 8.3 g 2,5-dimethoxybenzaldehyde (GC/MS: 98%+ 2,5-dimethoxybenzaldehyde)
Definition
ChEBI: 2,5-dimethoxy-Benzaldehyde is a dimethoxybenzene.
2,5-Dimethoxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2966 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2534 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 | sales1@nuowei-chem.com | China | 1640 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5882 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3138 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3878 | 58 |
Nanjing Deda New Material Technology Co., Ltd | +8613223293093 | bella@njdeda.com | China | 80 | 58 |
Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 | sales1@hbganmiao.com | China | 253 | 58 |
View Lastest Price from 2,5-Dimethoxybenzaldehyde manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | 2,5-Dimethoxybenzaldehyde
93-02-7
|
US $50.00-200.00 / g | 20g | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-09-20 | 2,5-Dimethoxybenzaldehyde
93-02-7
|
US $999.00-800.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | ||
2024-09-20 | 2,5-Dimethoxybenzaldehyde
93-02-7
|
US $1.00 / g | 1g | 99% | 20 tons | Dorne Chemical Technology co. LTD |
- 2,5-Dimethoxybenzaldehyde
93-02-7
- US $50.00-200.00 / g
- 98%
- hebei hongtan Biotechnology Co., Ltd
- 2,5-Dimethoxybenzaldehyde
93-02-7
- US $999.00-800.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- 2,5-Dimethoxybenzaldehyde
93-02-7
- US $1.00 / g
- 99%
- Dorne Chemical Technology co. LTD