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Naftifine hydrochloride

Local antifungal agents Uses
Naftifine hydrochloride
Naftifine hydrochloride structure
CAS No.
65473-14-5
Chemical Name:
Naftifine hydrochloride
Synonyms
NAFTINE HCL;Natifine Hcl;NAFTIFINE HCL;NAFTIFINE HYDROCHLORIDE;NAFTIFENE HYDROCHLORIDE;Naftifine hyrdrochloride;Exoderil, Naftin, Suadian,;Exoderil,Naftin(R),Suadian;Acyclovir-d4 Solution, 100ppm;Naftifine Hydrochloride (200 mg)
CBNumber:
CB6349312
Molecular Formula:
C21H22ClN
Formula Weight:
323.86
MOL File:
65473-14-5.mol

Naftifine hydrochloride Properties

Melting point:
172-175°C
storage temp. 
-20?C Freezer
solubility 
ethanol: soluble50mg/mL
Merck 
14,6355
CAS DataBase Reference
65473-14-5(CAS DataBase Reference)

SAFETY

Safety Statements  24/25
WGK Germany  nwg
RTECS  QJ8650000
HS Code  29214990

Naftifine hydrochloride price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N1790 Naftifine hydrochloride ≥99% 65473-14-5 50mg $128 2018-11-20 Buy
Sigma-Aldrich 1450404 Naftifine hydrochloride United States Pharmacopeia (USP) Reference Standard 65473-14-5 200mg $352.8 2018-11-20 Buy
TCI Chemical C1162 N-trans-Cinnamyl-N-methyl-(1-naphthylmethyl)amine Hydrochloride >98.0%(T) 65473-14-5 1g $252 2018-11-22 Buy
TCI Chemical C1162 N-trans-Cinnamyl-N-methyl-(1-naphthylmethyl)amine Hydrochloride >98.0%(T) 65473-14-5 5g $826 2018-11-22 Buy
Cayman Chemical 19234 Naftifine (hydrochloride) ≥98% 65473-14-5 50mg $30 2018-11-19 Buy

Naftifine hydrochloride Chemical Properties,Uses,Production

Local antifungal agents

Naphthalene hydrochloride, also known as cinnamonyl methylamine, naphthalene, and naphthalene hydrochloride, is currently one of the commonly used drugs for fungal infection in Department of Dermatology, belonging to the local antifungal agents of acrylamines. It has bactericidal effect on the dermatophytes (Trichophyton, Microsporum and epidermis Trichophyton). It has bacteriostasis against Malassezia, Candida and other yeasts. It also has local bactericidal effect on Gram-positive and negative bacteria. The mechanism of its action is to inhibit the fungal squalene cyclooxygenase. It interferes with the biosynthesis of ergosterol in fungal cell wall. It affects the lipid metabolism of fungi and causes the damage or death of fungal cells to play a bactericidal and bacteriostasis effect. It is suitable for dermatophytosis caused by sensitive fungi, such as tinea corporis, tinea pedis, tinea capitis, onychomycosis, tinea versicolor, superficial candidiasis as well as erasing fungal disease in the skin folds. For the the external application of 1% Naftifine Hydrochloride Ointment on the skin by thehealthy people, about 3% to 6% of the doses can be absorbed.The concentration of naphthofinn on the surface of the skin at a single dose within 24 hours is sufficient to inhibit the growth of dermatitis. Naftifine can be converted to at least three metabolites through the oxidation of benzene ring and naphthalene and N- alkylation in the body. About 40% to 60% of the drugs in the body are excreted in the form of the original and metabolite form into the urine, and the rest is excreted into the feces by the bile. The half-life of the skin external use of naftifine is about 2~3 days.

Usage and dosage: external use. For the skin infection, usually 1 times /d, and gently rub. The skin within 2.5cm centred on the infection should be coated with the drug. For erasing fungal disease, a ribbon gauze containing this product can be disposed at night in wrinkles.

Duration of treatment: 2-4 weeks for dermatophyte infection and 8 weeks in severe cases; 4 weeks for superficial moniliasis;6 months for Onychomycosis ; 2 weeks for pityriasis versicolor. For the prevention of recurrence, the treatment continues for about 2 weeks after all the signs of infection have disappeared.

Uses

Used as antibiotic drugs, antifungal agents with broad spectrum and strong effect. The curative effect is good and fast with high the safety and survivability. It is for the treatment of dermatophyte infection, superficial moniliasis, Onychomycosis and skin and its accessories (hair finger, fingernail and toe) by achorion, microspore and epidermis Trichophyton. Indications include erasing mycosis of the lower breast as well as erasing mycosis between finger (toes), the buttocks, and the groin.This product has the characteristics of broad antifungal spectrum and low toxicity.

Description

Naftifine hydrochloride is a topical antifungal agent which acts via inhibiting squalene epoxidase. It demonstrates good activity against Trichophyton, Epidermophyton, Microsporum, Aspergillus, and species. It is the prototype of a significantly improved series of antifungal agents, exemplified by SF 86-327 in which the phenyl group of naftifine has been replaced by t-butylace tylene.

Chemical Properties

White Powder

Originator

Sandoz (Switzerland)

Uses

Antimycotic allylamine. An antifungal (topical) agent.

Uses

An antifungal agent

brand name

Naftin (Merz);EXODERIL.

General Description

N-Methyl-N-(3-phenyl2-propenyl)-1-naphthalenemethanaminehydrochloride (Naftin) is a white crystallinepowder that is soluble in polar solvents such asethanol and methylene chloride. It is supplied in a 1% concentrationin a cream and in a gel for the topical treatmentof ringworm, athlete’s foot, and jock itch. Although unapprovedfor these uses, naftifine has shown efficacy fortreatment of ringworm of the beard, ringworm of the scalp,and tinea versicolor.

Clinical Use

Naftifine hydrochloride (Naftin) is available for topical use only in the treatment of cutaneous dermatophyte and Candida infections; it is as effective as topical azoles for these conditions.

Naftifine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Naftifine hydrochloride Suppliers

Global( 151)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21935 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1529 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23959 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20084 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8266 58
Hubei xin bonus chemical co. LTD
13657299721
zhangyuzhu@xhlchem.com CHINA 17424 58

View Lastest Price from Naftifine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-16 Naftifine hydrochloride
65473-14-5
US $7.00 / kg 1kg 99% 100kg career henan chemical co
2018-08-20 Naftifine hydrochloride
65473-14-5
US $1.00 / KG 1G 98% 100KG career henan chemical co

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