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Mifepristone structure
Chemical Name:
RU486;r38486;C-1073;VGX 410;ru486-6;Mifeprex;MIFEGYNE;RU-38486;Mifestone;Mifepriston
Molecular Formula:
Formula Weight:
MOL File:

Mifepristone Properties

Melting point:
D20 +138.5° (c = 0.5 in chloroform)
Boiling point:
544.13°C (rough estimate)
1.0731 (rough estimate)
refractive index 
1.6290 (estimate)
storage temp. 
Yellow solid
CAS DataBase Reference
84371-65-3(CAS DataBase Reference)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  60-61
Safety Statements  53-22-36/37/39-45
WGK Germany  3
RTECS  KG2955000
HS Code  29372900
Hazardous Substances Data 84371-65-3(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P501 Dispose of contents/container to..…

Mifepristone price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 475838 Mifepristone 84371-65-3 50mg $75.2 2018-11-20 Buy
Sigma-Aldrich 1443759 Mifepristone United States Pharmacopeia (USP) Reference Standard 84371-65-3 200mg $460.6 2018-11-20 Buy
TCI Chemical M1732 Mifepristone >98.0%(T)(HPLC) 84371-65-3 1g $184 2018-11-22 Buy
TCI Chemical M1732 Mifepristone >98.0%(T)(HPLC) 84371-65-3 5g $604 2018-11-22 Buy
Cayman Chemical 10006317 Mifepristone ≥98% 84371-65-3 100mg $25 2018-11-19 Buy

Mifepristone Chemical Properties,Uses,Production


Mifepristone is a kind of antagonist of the progestational and glucocorticoid hormone. It is mainly used for the treatment of hypercortisolism in patients with nonpituitary cushing syndrome. During the treatment of Cushing’s syndrome, mifepristone takes effect through interfering with the binding of cortisol to its receptor. It reduces the effects of excess cortisol (e.g., high blood sugar levels) without causing decreased cortisol production. It can also be used to end a pregnancy. Its inhibition on progesterone can induce bleeding during the luteal phase and in early pregnancy.  


Mifepristone is an orally-active progesterone and glucocorticoid receptor antagonist indicated for use as a post-coital contraceptive. In addition to being an abortifacient, mifepristone is reported to be effective in the treatment of ocular hypertension; its potential therapeutic effect in hormone-dependent tumors is currently under investigation.

Chemical Properties

Pale Yellow Solid


Roussel-Uclaf (France)


glutamate uptake inhibitor, AMPA blocker


A progesterone and glucocorticoid antagonist, suppresses VEGF production.


A progesterone receptor antagonist with partial agonist activity. Abortifacient.


Mifepristone is a progesterone receptor antagonist that has a high affinity for glucocorticoid receptors and little agonist effect.This drug has recently been approved for use in the United States for the treatment of hypercortisolism. At high doses, mifepristone blocks negative feedback of the hypothalamic–pituitary axis, thereby increasing endogenous corticotrophin and cortisol levels. Because mifepristone exerts its effects at the receptor level and not by altering glucocorticoid production, elevated serum cortisol and corticotrophin levels may not accurately reflect the effectiveness of the therapeutic regimen. Mifepristone does not inhibit cortisol binding to the mineralocorticoid receptor, so that the resulting corticotrophin disinhibition may cause potassium depletion. Thus, administration of a mineralocorticoid receptor antagonist such as spironolactone may be indicated with mifepristone. Hypoadrenalism, nausea, and drowsiness have been reported during prolonged administration of mifepristone.

brand name

Mifeprex (Danco);Ru-486;Mifegyne.

World Health Organization (WHO)

Mifepristone, an antiprogesterone used in combination with a prostaglandin for the termination of early pregnancy, was introduced in 1990. Use of the combination has been associated with episodes of coronary spasm that are attributed to administration of the prostaglandin and which have resulted in several cases of cardiac infarction and ventricular fibrillation. At least one of these incidents has been fatal.

Biological Activity

Selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo . Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone.


Mifepristone Preparation Products And Raw materials

Raw materials

Preparation Products

Mifepristone Suppliers

Global( 287)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3194 55
Meihua Biological Technology Co.,Ltd
031145896235 CHINA 210 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 892 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 27142 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 CHINA 696 58

View Lastest Price from Mifepristone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Mifepristone
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-11-06 Mifepristone
US $1226.00-100.00 / G 10G 99.7%+ 600kg/month Hebei Huanhao Biotechnology Co., Ltd.
2018-09-30 Mifepristone
US $50.00 / KG 1KG 99% 20 MT Hebei Huanhao Biotechnology Co., Ltd.

Mifepristone Spectrum

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