ChemicalBook >> CAS DataBase List >>Naftopidil dihydrochloride
Naftopidil dihydrochloride
- CAS No.
- 57149-07-2
- Chemical Name:
- Naftopidil dihydrochloride
- Synonyms
- kt-611;Flivas;Avishot;Naftopil;BM-15275;Naftopiil;NafTopIDi1;NAFTOPIDIL;Nafitopidil;Naftopidil>
- CBNumber:
- CB6356910
- Molecular Formula:
- C24H28N2O3
- Molecular Weight:
- 392.49
- MDL Number:
- MFCD00153845
- MOL File:
- 57149-07-2.mol
Last updated:2023-05-18 11:31:00
| Melting point | 127 °C |
|---|---|
| Boiling point | 517.2°C (rough estimate) |
| Density | 1.1592 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | methanol: >10 mg/mL |
| form | solid |
| pka | 14.01±0.20(Predicted) |
| color | white |
| Merck | 14,6356 |
| CAS DataBase Reference | 57149-07-2(CAS DataBase Reference) |
| FDA UNII | R9PHW59SFN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| RIDADR | 3077 |
| WGK Germany | 3 |
| RTECS | TL9336500 |
| HS Code | 29335990 |
| Toxicity | LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel) |
Naftopidil dihydrochloride price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N158 | Naftopidil hydrochloride hydrate solid | 57149-07-2 | 25mg | $240 | 2024-03-01 | Buy |
| Sigma-Aldrich | N158 | Naftopidil hydrochloride hydrate solid | 57149-07-2 | 100mg | $774 | 2023-01-07 | Buy |
| TCI Chemical | N0832 | Naftopidil >98.0%(HPLC)(T) | 57149-07-2 | 5g | $50 | 2024-03-01 | Buy |
| TRC | N213501 | Naftopidil | 57149-07-2 | 25mg | $80 | 2021-12-16 | Buy |
| Usbiological | 285070 | Naftopidil | 57149-07-2 | 1g | $345 | 2021-12-16 | Buy |
Naftopidil dihydrochloride Chemical Properties,Uses,Production
Description
Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.
Chemical Properties
Off-White Solid
Originator
Boehringer Mannheim (Germany)
Uses
A α-1-Adrenergic receptor antagonist, antihypertensive.
Uses
Naftopidil is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.
Uses
antihypertensive, alpha-blocker, 5HT1a agonist
Definition
ChEBI: Naftopidil is a member of piperazines.
brand name
Avishot;Flivas
Biological Activity
An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.
Naftopidil dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 351)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 |
View Lastest Price from Naftopidil dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-06-26 | Naftopidil
57149-07-2
|
US $120.00 / ASSAYS | 10g | >99% | 500kg/month | Hebei Mingeng Biotechnology Co., Ltd | |
 |
2023-04-12 | Naftopidil dihydrochloride
57149-07-2
|
US $1.00 / kg | 1kg | 99% | 3500tons/year | Wuhan Dujiang Industrial Co., Ltd. | |
 |
2023-03-06 | Naftopidil
57149-07-2
|
US $19.10 / KG | 1KG | 99% | 10 ton | Hebei Guanlang Biotechnology Co,.LTD |
-
- Naftopidil
57149-07-2
- US $120.00 / ASSAYS
- >99%
- Hebei Mingeng Biotechnology Co., Ltd
-
- Naftopidil dihydrochloride
57149-07-2
- US $1.00 / kg
- 99%
- Wuhan Dujiang Industrial Co., Ltd.
-
- Naftopidil
57149-07-2
- US $19.10 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
57149-07-2(Naftopidil dihydrochloride)Related Search:
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(+-)-1-(4-(2-methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol
4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethano
4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol
kt-611
NAFTOPIDIL DIHYDROCHLORIDE (KT-611) A1 A DRENOCEPTOR ANTAG
NAFTOPIDIL
NafTopIDi1
4-(2-Methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol dihydrochloride
Naftopidil dihydrochloride
Avishot
Flivas
Naftopidil Dihydrochloride See: N213501
rac-4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Dihydrochloride
4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol,
4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol dihydrochloride
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3-[4-(2-Methoxyphenyl)piperazinyl]-1-naphthyloxypropan-2-ol
Naftopidil and intermediates
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxy-propan-2-ol
(R)-1-(1-Naphtyloxy)-3-[4-(2-methoxyphenyl)piperazino]-2-propanol
[R,(+)]-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol
(S)-1-(1-Naphtyloxy)-3-[4-(2-methoxyphenyl)piperazino]-2-propanol
[S,(-)]-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol
1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphtyloxy)-2-propanol
4-(2-Methoxyphenyl)-α-[(naphthalen-1-yloxy)methyl]piperazine-1-ethanol
4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate
4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanolhydrochloride
rac-4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Dihydrochloride
4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol,
KT-611, 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrate hydrochloride
Naftopidil hydrate hydrochloride
Naftopidil(Flivas)
CAS No:57149-07-2 1-Piperazineethanol,4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)Methyl]-
Naftopiil
Naftopil
Naftopidil hydrochloride hydrate
1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthalenyloxy)-2-propanol dihydrochloride
Nafitopidil
Naftopidil dihydrochloride/Naftopidil
BM-15275
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol
Naftopidil, 98%, a selective α1-adrenergic receptor antagonist
Naftopidil>
Naftopidil Naftopidil
Naftopidil,>98%
1-Piperazineethanol, 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-
4-(2-Methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol
Naftopidil hydrochlo
Naftopidil D7Q: What is
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Naftopidil D7
NaftopidilQ: What is
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Naftopidil Q: What are the applications of
Naftopidil
1-Piperazineethanol, 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-
Naftopidil, ≥ 98.0%
57149-07-2
7149-07-2
C24H28N2O3
C24H30Cl2N2O3
C24H28N2O3HCl
AVISHOT