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Heptaethylene Glycol Monomethyl Ether

Heptaethylene Glycol Monomethyl Ether structure

CAS No.: 4437-01-8

Chemical Name:: Heptaethylene Glycol Monomethyl Ether

Synonyms: 2,5,8,11,14,17,20-Heptaoxadocosan-22-ol;mPEG7;MPEG7-OH;m-PEG7-alcohol;926630;MEO-PEG(7)-OH;HO-(CH2CH2O)7-Me;Methyl-PEG7-alcohol;MONOMETHOXY-PEG (N=7);METHOXYHEPTAETHYLENE GLYCOL

CBNumber:: CB6362485

Molecular Formula:: C15H32O8

Molecular Weight:: 340.41

MDL Number:: MFCD06201006

MOL File:: 4437-01-8.mol

MSDS File:: SDS

Last updated:2026-01-28 17:20:35

Product description	Number	Pack Size	Price
O-Methyl-heptaethylene glycol ≥95% (oligomer purity)	41749	1G	$130.2
Heptaethylene Glycol Monomethyl Ether >97.0%(GC)	H1046	1g	$108
Heptaethylene Glycol Monomethyl Ether >97.0%(GC)	H1046	5g	$373
Heptaethylene Glycol Monomethyl Ether 97%	JK441840	1g	$375
Heptaethylene Glycol Monomethyl Ether	Y4948	5g	$359
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Heptaethylene Glycol Monomethyl Ether Properties

Boiling point	150 °C(Press: 0.005 Torr)
Density	1.09
refractive index	1.4540-1.4580
storage temp.	-20°C
form	clear liquid
pka	14.36±0.10(Predicted)
color	Colorless to Light yellow to Light orange
InChI	InChI=1S/C15H32O8/c1-17-4-5-19-8-9-21-12-13-23-15-14-22-11-10-20-7-6-18-3-2-16/h16H,2-15H2,1H3
InChIKey	AGWKUHGLWHMYTG-UHFFFAOYSA-N
SMILES	C(O)COCCOCCOCCOCCOCCOCCOC
CAS DataBase Reference	4437-01-8(CAS DataBase Reference)
UNSPSC Code	12352200
NACRES	NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

PPE

Eyeshields, Gloves

WGK Germany

HS Code

29094990

Storage Class

10 - Combustible liquids

NFPA 704

	0
1		0

Heptaethylene Glycol Monomethyl Ether price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	41749	O-Methyl-heptaethylene glycol ≥95% (oligomer purity)	4437-01-8	1G	$130.2	2025-07-31	Buy
TCI Chemical	H1046	Heptaethylene Glycol Monomethyl Ether >97.0%(GC)	4437-01-8	1g	$108	2025-07-31	Buy
TCI Chemical	H1046	Heptaethylene Glycol Monomethyl Ether >97.0%(GC)	4437-01-8	5g	$373	2025-07-31	Buy
Frontier Specialty Chemicals	JK441840	Heptaethylene Glycol Monomethyl Ether 97%	4437-01-8	1g	$375	2021-12-16	Buy
AK Scientific	Y4948	Heptaethylene Glycol Monomethyl Ether	4437-01-8	5g	$359	2021-12-16	Buy

Product number	Packaging	Price	Buy
41749	1G	$130.2	Buy
H1046	1g	$108	Buy
H1046	5g	$373	Buy
JK441840	1g	$375	Buy
Y4948	5g	$359	Buy

Heptaethylene Glycol Monomethyl Ether Chemical Properties,Uses,Production

Description

m-PEG7-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Definition

The presence of heptaethylene glycol monomethyl ether (HGME) as a process impurity and degradation impurity in the final purified form of Benzonatate is a determining factor in establishing the safety, identity, strength, purity, and quality of the drug substance. Owing to the cutaneous toxicity of HGME in the BNZ drug substance, a suitable and selective analysis method is required for its quantitation[1].

reaction suitability

reagent type: cross-linking reagent

Synthesis

112-60-7

74654-05-0

4437-01-8

A 60% NaH dispersion in mineral oil was added in batches to a stirred solution of triacetylene glycol (35.7 mmol) in anhydrous DMF (25.7 mL) under nitrogen protection, and the mixture was stirred for 1 hour at room temperature. Subsequently, a solution of 2-(2-(2-methoxyethoxy)ethoxy)ethyl methanesulfonate (23.36 mmol) in anhydrous DMF (4 mL) was added in a single addition to the resulting salt, and stirring was continued for 3.5 hours at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC with 12% unfolding agent ratio). Upon completion of the reaction, the reaction mixture was diluted with an equal volume of 1N HCl, extracted with ethyl acetate (2 x 20 mL) and the organic phase discarded. The aqueous phase was extracted and post-treated to give heptaglycol monomethyl ether in 82-84% yield.

IC 50

PEGs

References

[1] Lakshmi Narasimha Rao Katakam, Vishnu Murthy Marisetti, Santhosh Kumar Ettaboina. “Development and validation of LC–MS method for the determination of heptaethylene glycol monomethyl ether in benzonatate bulk drugs.” Biomedical Chromatography 35 7 (2021).

Heptaethylene Glycol Monomethyl Ether Preparation Products And Raw materials

Raw materials

tetraethylene glycol Methyl-PEG3-MS Hexaethylene glycol 1-Bromo-2-methoxyethane Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-, sodium salt (1:2)

N,N-Dimethylformamide Sodium hydride

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Preparation Products

mPEG6-CH2COOH m-PEG8-Tos m-PEG7-CH2COOH

Heptaethylene Glycol Monomethyl Ether Suppliers

Global( 191)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhejiang Kinso Technology Co., LTD.	+86-571-56950601; +8619857958369	sales@kinsopharma.com	China	49	58
LAURENT	+8618100176782	sun@laurentpeg.com	China	365	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
9i LLC	+18039569191	MWan@NiNeiLab.com	United States	418	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd.	0431-80514535 13634302652	Extension@chemextension.com	CHINA	967	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58

Supplier	Advantage
Zhejiang Kinso Technology Co., LTD.	58
LAURENT	58
Hebei Chuanghai Biotechnology Co., Ltd	58
9i LLC	58
ATK CHEMICAL COMPANY LIMITED	60
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd.	58
Accela ChemBio Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58

View Lastest Price from Heptaethylene Glycol Monomethyl Ether manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-05	2,5,8,11,14,17,20-heptaoxadocosan-22-ol 4437-01-8	US $0.00-0.00 / g	1g	98%	1g/bottle, 10g/bottle, 100g/bottle	XIAMEN SINOPEG BIOTECH CO., LTD.
2026-01-28	mPEG7-OH 4437-01-8	US $0.00-0.00 / g	1g	98%	300kg	LAURENT
2026-01-05	m-PEG7-alcohol 4437-01-8	US $29.00 / mg		96.02%	10g	TargetMol Chemicals Inc.

2,5,8,11,14,17,20-heptaoxadocosan-22-ol
4437-01-8
US $0.00-0.00 / g
98%
XIAMEN SINOPEG BIOTECH CO., LTD.

mPEG7-OH
4437-01-8
US $0.00-0.00 / g
98%
LAURENT

m-PEG7-alcohol
4437-01-8
US $29.00 / mg
96.02%
TargetMol Chemicals Inc.

Heptaethylene Glycol Monomethyl Ether Spectrum

Heptaethylene Glycol Monomethyl Ether(4437-01-8)¹HNMR

4437-01-8(Heptaethylene Glycol Monomethyl Ether )Related Search:

1-{2-[2-(2-{2-[2-(2-Bromo-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-2-methoxy-ethane mPEG6-CH2COOH 2,5,8,11,14,17,20-Heptaoxadocosane-22-thiol m-PEG7-aldehyde Polyethylene Glycol Monocetyl Ether

POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER NONAETHYLENE GLYCOL MONODODECYL ETHER C10 E8 C14E8 Dicyclohexano-24-crown-8

C12E8 HEPTAETHYLENE GLYCOL MONODODECYL ETHER POLY(ETHYLENE GLYCOL) (N) MONOMETHACRYLATE Polyoxyethylene lauryl ether C16 E8

Benzonatate Polyoxyethylene stearate HEPTAETHYLENE GLYCOL

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Heptaetheylene glycol methyl ether HEPTAETHYLENE GLYCOL MONOMETHYL ETHER Methoxyheptaethylene glycol, Monomethoxy-PEG (n=7) Heptaetheylene glycol MonoMethyl ether 3,6,9,12,15,18,21-heptaoxadocosan-1-ol Methyl-PEG7-alcohol O-METHYL-HEPTAETHYLENE GLYCOL MONOMETHOXY-PEG (N=7) METHOXYHEPTAETHYLENE GLYCOL MEO-PEG(7)-OH HEPTA(ETHYLENE GLYCOL) METHYL ETHER 2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol HeptaethyleneGlycolMonomethylEther> HEPTAETHYLENE GLYCOL MONOMETHYL ETHER ISO 9001：2015 REACH HO-(CH2CH2O)7-Me 926630 m-PEG7-alcohol 2,5,8,11,14,17,20-Heptaoxadocosan-22-ol MPEG7-OH mPEG7 mPEG7-OH/Heptaethylene Glycol Monomethyl Ether O-Methyl-heptaethylene glycol 2,5,8,11,14,17,20-Heptaoxadocosan-22-ol 97%min 4437-01-8 926-63-0 4377-01-8 HOCH2CH2O7CH3 C15H32O8 Monofunctional Ethylene Glycols Ethylene Glycols & Monofunctional Ethylene Glycols Peptide Synthesis Peptide PEGylation Specialty Synthesis High Oligomer Purity PEG Chemical Biology Chemical Synthesis High Oligomer Purity PEG PEGylation Monofunctional Ethylene Glycols Ethylene Glycols & Monofunctional Ethylene Glycols PEG-COOH peg