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4-Trifluoromethylphenol

Preparation method Chemical Characteristics Uses
4-Trifluoromethylphenol
4-Trifluoromethylphenol structure
CAS No.
402-45-9
Chemical Name:
4-Trifluoromethylphenol
Synonyms
TFMPO;P-Trifluoromethyl;Fluoxetine Impurity 4;TRIFLUORO-PARA-CRESOL;4-trifluorotoluolphenol;4-HYDROXYBENZOTRIFLUORI;p-TrifluoroMethylphenyl;α,α,α-Trifluoro-p-cresol;Fluoxetine EP Impurity D;4-HYDROXYBENZOTRIFLUORIDE
CBNumber:
CB6371577
Molecular Formula:
C7H5F3O
Formula Weight:
162.11
MOL File:
402-45-9.mol

4-Trifluoromethylphenol Properties

Melting point:
45-47 °C(lit.)
Boiling point:
71.5-72 °C (8 mmHg)
Density 
1.3226 (estimate)
Flash point:
183 °F
storage temp. 
0-6°C
pka
pK1:8.675 (25°C)
form 
Crystals
color 
White to yellow-brown
BRN 
1637019
InChIKey
BAYGVMXZJBFEMB-UHFFFAOYSA-N
CAS DataBase Reference
402-45-9(CAS DataBase Reference)
NIST Chemistry Reference
p-Hydroxybenzotrifluoride(402-45-9)
EPA Substance Registry System
4-(Trifluoromethyl)phenol (402-45-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS05
Signal word  Danger
Hazard statements  H228-H301-H315-H318-H335
Precautionary statements  P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P310-P210-P261-P280-P301+P310-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  22-37/38-41-36/37/38
Safety Statements  26-39-24/25
RIDADR  UN 2926 4.1/PG 2
WGK Germany  3
Hazard Note  Irritant/Keep Cold
PackingGroup 
HS Code  29081000

4-Trifluoromethylphenol price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 178470 4-(Trifluoromethyl)phenol 97% 402-45-9 5g $83.6 2020-08-18 Buy
Sigma-Aldrich 178470 4-(Trifluoromethyl)phenol 97% 402-45-9 1g $27.3 2020-08-18 Buy
TCI Chemical H0644 4-Hydroxybenzotrifluoride >98.0%(GC)(T) 402-45-9 5g $92 2020-06-24 Buy
TCI Chemical H0644 4-Hydroxybenzotrifluoride >98.0%(GC)(T) 402-45-9 25g $273 2020-06-24 Buy
Sigma-Aldrich 8.41244 4-Hydroxybenzotrifluoride for synthesis. CAS 402-45-9, molar mass 162.11 g/mol., for synthesis 402-45-9 8412440001 $50.4 2020-08-18 Buy

4-Trifluoromethylphenol Chemical Properties,Uses,Production

Preparation method

Chlorosilane and bromotrifluoromethane at-59℃form trifluoromethylsilane. Trifluoromethylsilane and benzoquinone in the presence of catalyst form 4-triethylsiloxy-4-trifluoromethyl-2,5-cyclohexadien-1-ketone which is reduced by zinc powder to p-trifluoromethylphenol with a yield of 71%. This method avoids the use of  hydrofluoric acid in the traditional process but  should be carried out under anhydrous conditions.If there were water trifluoromethyl silane would rapidly become silanol under the effect of water and alkali. The catalyst used in the reaction is alkali of which the strength has nothing to do with the catalytic activity. By now the role of catalyst is still unknown but the reaction can not proceed without catalyst.

Chemical Characteristics

Off-white crystal

Uses

For intermediate of medicine and pesticide.

Chemical Properties

White to yellowish-brown crystals

Uses

Intermediates of Liquid Crystals

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 2873, 1989 DOI: 10.1021/jo00273a020

4-Trifluoromethylphenol Preparation Products And Raw materials

Raw materials

Preparation Products


4-Trifluoromethylphenol Suppliers

Global( 326)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Fluoropharm Co., Ltd.
+8613336034509
+86 0571-85586753 sales@fluoropharm.com CHINA 894 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24886 60
Anhui Royal Chemical Co., Ltd.
+86-025-86655873
marketing@royal-chem.com CHINA 537 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
QINGDAO HONG JIN CHEMCIAL CO.,LTD.
+86 532 83657313
hjt@hong-jin.com CHINA 230 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Shanghai Worldyang Chemical Co.,Ltd.
+86-13651600618,+86-21-56795779
sales@worldyachem.com CHINA 822 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14344 58
BOC Sciences
1-631-619-7922 1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58

View Lastest Price from 4-Trifluoromethylphenol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-02 4-Trifluoromethylphenol
402-45-9
US $100.00 / KG 1KG 99% Customized career henan chemical co

4-Trifluoromethylphenol Spectrum


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