Chlorophacinone
- CAS No.
- 3691-35-8
- Chemical Name:
- Chlorophacinone
- Synonyms
- YY1;lm91;CAID;DRAT;delta;LM 91;Quick;Ranac;Rozol;NF-E1
- CBNumber:
- CB6372862
- Molecular Formula:
- C23H15ClO3
- Molecular Weight:
- 374.82
- MDL Number:
- MFCD00055360
- MOL File:
- 3691-35-8.mol
| Melting point | 138° |
|---|---|
| Boiling point | 490.38°C (rough estimate) |
| Density | 1.1517 (rough estimate) |
| refractive index | 1.4585 (estimate) |
| Flash point | >100 °C |
| storage temp. | -20°C |
| pka | 2.61±0.10(Predicted) |
| Merck | 13,2171 |
| EWG's Food Scores | 2-5 |
| FDA UNII | 34Y6E0063Y |
| NIST Chemistry Reference | Chlorophacinone(3691-35-8) |
| Pesticides Freedom of Information Act (FOIA) | Chlorophacinone |
| EPA Substance Registry System | Chlorophacinone (3691-35-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300-H310-H331-H372-H410 |
| Precautionary statements | P261-P264-P273-P280-P301+P310-P302+P350 |
| Hazard Codes | T+;N,N,T+ |
| Risk Statements | 23-27/28-48/24/25-50/53 |
| Safety Statements | 36/37-45-60-61 |
| RIDADR | UN 2811 |
| RTECS | NK5335000 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29147000 |
| Toxicity | LD50 oral in rabbit: 50mg/kg |
Chlorophacinone Chemical Properties,Uses,Production
Description
Chlorophacinone is produced by condensation of 1-
phenyl-1-(4-chlorophenyl) acetone with dimethyl phthalate
in the presence of sodium methoxide (31).
This compound was introduced in 1961 and is now
widely used in Europe, the United States, and elsewhere.
It is used in baits against norway rats at a concentration
of 0.005–0.01%. Bait containing 0.025% chlorophacinone
gave a complete kill of house mice after a 7-d feeding
period but, in other tests, survivors were recorded following
10 and 21 days of feeding (5). Chlorophacinone acts as
an uncoupler of oxidative phosphorylation as well as an
anticoagulant (32), which is unusual among this group of
compounds.
Chemical Properties
Chlorophacinone is a highly toxic crystalline solid.
Uses
Chlorophacinone (CPN) is an anticoagulant rodenticide widely used to control rodent infestations.
Uses
Anticoagulant rodenticide.
Definition
ChEBI: Chlorophacinone is a diarylmethane and a beta-triketone.
General Description
Crystals. Commercially available as oil concentrate and as dust concentrate. Used as an anticoagulant rodenticide. Chronic acting, multiple dose rodenticide.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Fire may produce irritating or poisonous gases.
Health Hazard
Chlorphacinon is highly toxic orally and by skin absorption. The probable oral lethal dose for humans is less than 5 mg/kg to 50 mg/kg, or between a taste (less than 7 drops) and 1 teaspoonful for a 150 lb. (70 kg) person.
Health Hazard
Highly toxic anticoagulant rodenticide; lowchlorine content but highly toxic; exhibitsacute, delayed, and chronic poisoning;symptoms include bleeding of nose andgum, blood in cough, urine, and stool,abdominal pain and hemorrhage; can beabsorbed through skin causing systemicpoisoning; ingestion of 1–2 g is estimatedto be fatal dose for adult human; U.S. EPAlisted extremely hazardous substance.
LD50 oral (rat): ～2 mg/kg
LD50 oral (mouse): ～1 mg/kg
LD50 oral (rabbit): 50 mg/kg
LD50 skin (rabbit): 200 mg/kg.
Fire Hazard
(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Fire may produce irriating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution. When heated Chlorphacinon emits toxic fumes of chlorides.
Agricultural Uses
Rodenticide: This material is an anticoagulant rodenticide used around livestock and also on crops such as artichokes. Some brands are labeled for use indoors and outdoors for the control of mice, rats, moles, muskrats, voles and vampire bats. Not approved for use in EU countries. Registered for use in the U.S. There are 24 global suppliers.
Trade name
AFNOR®; CAID®; DELTA®; DRAT RAT BAIT®; ENDORATS®; LIPHADIONE®; LM 91®; MICROZUL®; MURIOL®; PARTOX®[C]; QUICK®; RAMUCIDE®; RANAC®; RATOMET®; RAVIAC®; ROZOL®[C]; TOPITOX®
Safety Profile
Poison by ingestion and skin contact. Human systemic effects by ingestion: vascular changes. A pesticide. When heated to decomposition it emits toxic fumes of Cl-.
Potential Exposure
Agricultural Chemical. This material is an anticoagulant rodenticide. A potential danger to those involved in its manufacture, formulation, and application are at risk.
First aid
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 minutes, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
storage
Color Code—Green: General storage may be used.Prior to working with this chemical you should be trainedon its proper handling and storage. Store in tightly closedcontainers in a cool, well-ventilated area.
Shipping
UN3027 Coumarin derivative pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Waste Disposal
Incineration at high temperature with effluent gas scrubbing.
