ChemicalBook
Chinese Japanese Germany

Rifapentine

Rifapentine
Rifapentine
CAS No.
61379-65-5
Chemical Name:
Rifapentine
Synonyms
ktc1;dl473;r-773;mdl473;Priftin;Prifitin;Rifapenti;Rifapentin;PIFAPENTINE;RIFAPENTINE
CBNumber:
CB6381080
Molecular Formula:
C47H64N4O12
Formula Weight:
877.03
MOL File:
61379-65-5.mol

Rifapentine Properties

Melting point:
179-1800C
storage temp. 
-20°C Freezer
solubility 
methanol: soluble2mg/mL, clear, red to red-brown
form 
powder
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
RTECS  JQ0902000
Toxicity LD50 in mice (mg/kg): >2000 orally; 750 i.p. (Cricchio); LD50 in mice (mg/kg): 3300 orally; 710 i.p. (Aroli)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Rifapentine price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R0533 Rifapentine ≥93% 61379-65-5 25mg $89.1 2018-11-20 Buy
Sigma-Aldrich R0533 Rifapentine ≥93% 61379-65-5 100mg $292 2018-11-20 Buy
Cayman Chemical 20307 Rifapentine ≥98% 61379-65-5 50mg $99 2018-11-19 Buy
Cayman Chemical 20307 Rifapentine ≥98% 61379-65-5 100mg $188 2018-11-19 Buy
Cayman Chemical 20307 Rifapentine ≥98% 61379-65-5 500mg $743 2018-11-19 Buy

Rifapentine Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Uses

antibacterial (tuberculostatic);'inhibits DNA-dependent RNA polymerase in susceptible strains of Mycobacterium tuberculosis

Uses

PDE5 inhibitor for erectile dysfunction A semisynthetic ansamycin antibiotic, cyclopentyl derivative of Rifamycin. Treatment of pulmonary tuberculosis

Uses

Semi-synthetic rifamycin. Antibacterial (tuberculostatic)

brand name

Priftin (Sanofi Aventis).

Antimicrobial activity

Activity is similar to that of rifampicin, but it is more active against atypical mycobacteria, especially the M. avium complex (MIC <0.06–0.5 mg/L). It has good activity on staphylococci and streptococci (MIC 0.01–0.5 mg/L), L. monocytogenes and Brucella spp.; less against Enterococcus faecalis (MIC 1–4 mg/L). Bacteroides spp. are inhibited by 0.5–2 mg/L. Gram-negative cocci are susceptible and, although some Gram-negative bacilli are inhibited by 4–32 mg/L, most are resistant.

Hazard

Moderately toxic by ingestion.

Pharmaceutical Applications

An analog of rifampicin in which a cyclopentyl group is substituted for a methyl group on the piperazine ring. It is available for oral administration.

Pharmacokinetics

Oral absorption:c. 70%
Cmax600 mg oral :12 mg/L after 5 h
Plasma half-life:13 h
Volume of distribution:1.5 L/kg
Plasma protein binding:97%
absorption
The absolute oral bioavailability of rifapentine has not been determined. The relative bioavailability of capsules (with an oral solution as reference) is 70%. Food increases absorption: a 600 mg dose taken after a meal gives Cmax and AUC values 44% higher than under fasting conditions. The extended halflife provides therapeutic concentrations for at least 72 h after administration, allowing less frequent dosing.
Distribution
Animal data suggest that it is well distributed in the body, with tissue concentrations exceeding the plasma concentration, except in bone, testes and brain. The ratio of intracellular:extracellular concentration in macrophages was estimated as 24:1.
Metabolism
The main metabolite is an antimicrobially active 25-desacetyl derivative. Although it induces liver cytochromes it is not an inducer of its own metabolism, which is mediated by an esterase. The peak concentration of 25-desacetyl rifapentine is about one-third of that of the unchanged drug, and is attained after about 11 h.
excretion
The main route of elimination is through the bile. In healthy volunteers about 70% of a 600 mg dose of 14C rifapentine was recovered in the feces, and less than 17% in the urine. There is evidence of enterohepatic recycling in humans.

Clinical Use

Tuberculosis (in combination with other antituberculosis drugs)

Side effects

Signs of teratogenic effects and fetal toxicity have been observed when administered during pregnancy to rats and rabbits. Rifapentine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The most common adverse effect observed in combinations with other antimycobacterial agents was hyperuricemia, most probably due to pyrazinamide. Effects likely to be due to rifapentine were neutropenia (3.7% of patients) and hepatitis (increased transaminases in 1.6% of patients).

Rifapentine Preparation Products And Raw materials

Raw materials

Preparation Products


Rifapentine Suppliers

Global( 134)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 955 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19990 58
Chengdu BoShi Technology Co., Ltd. 13982188065
- 2983871989@qq.com China 50 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6054 61
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
001-617-206-9595 sales@chemreagents.com United States 9943 62
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 19998 64
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32492 50

View Lastest Price from Rifapentine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Rifapentine
61379-65-5
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-08-20 Rifapentine
61379-65-5
US $1.00 / KG 1KG 98% 100KG career henan chemical co

61379-65-5(Rifapentine)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved