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3-Pyridinemethanol

CAS No.
100-55-0
Chemical Name:
3-Pyridinemethanol
Synonyms
NICOTINYL ALCOHOL;PYRIDIN-3-YLMETHANOL;3-(HYDROXYMETHYL)PYRIDINE;3-PYRIDYLCARBINOL;3-Pyridinylmethanol;3-PYRIDYLMETHANOL;Pyridyl-3-methanol;Nu-2121;RONICOL;Roniacol
CBNumber:
CB6384809
Molecular Formula:
C6H7NO
Molecular Weight:
109.13
MOL File:
100-55-0.mol

3-Pyridinemethanol Properties

Melting point -7 °C
Boiling point 154 °C/28 mmHg (lit.)
Density 1.124 g/mL at 25 °C (lit.)
refractive index n20/D 1.545(lit.)
Flash point >230 °F
storage temp. Inert atmosphere,Room Temperature
solubility 1000mg/l
pka 13.68±0.10(Predicted)
form liquid (clear)
color clear light yellow
PH 7-8 (100g/l, H2O, 20℃)
Water Solubility soluble
Sensitive Hygroscopic
Merck 14,6527
BRN 107851
InChIKey MVQVNTPHUGQQHK-UHFFFAOYSA-N
CAS DataBase Reference 100-55-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 9TF312056Y
NIST Chemistry Reference Nicotinyl Alcohol(100-55-0)
EPA Substance Registry System 3-Pyridinemethanol (100-55-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
RTECS  UT4690000
3-10-23
Hazard Note  Irritant
TSCA  Yes
HS Code  29333999
NFPA 704
1
2 0

3-Pyridinemethanol price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P66807 3-Pyridinemethanol 98% 100-55-0 1kg $508 2022-05-15 Buy
TCI Chemical P0555 3-Pyridinemethanol >98.0%(GC) 100-55-0 25mL $40 2022-04-27 Buy
TCI Chemical P0555 3-Pyridinemethanol >98.0%(GC) 100-55-0 500mL $463 2022-04-27 Buy
Alfa Aesar A10381 3-Pyridinemethanol, 98% 100-55-0 50g $37.9 2021-12-16 Buy
Alfa Aesar A10381 3-Pyridinemethanol, 98% 100-55-0 250g $127 2021-12-16 Buy
Product number Packaging Price Buy
P66807 1kg $508 Buy
P0555 25mL $40 Buy
P0555 500mL $463 Buy
A10381 50g $37.9 Buy
A10381 250g $127 Buy

3-Pyridinemethanol Chemical Properties,Uses,Production

Chemical Properties

CLEAR LIGHT YELLOW TO YELLOW LIQUID

Originator

Roniacol,Roche,US,1949

Uses

antineoplastic

Uses

3-Pyridinemethanol is a useful synthetic intermediate. It can be used in the synthesis of histone deacetylase inhibitors. It can also be used to prepare (phenyl)(cyanopyrazinyl)urea derivatives as possible kinase-1 (Chk1) inhibitors.

Uses

3-Pyridinemethanol can be used as antineoplastic and used in the synthesis of histone deacetylase inhibitors.

Manufacturing Process

The catalyst is prepared by suspending 5 kg of catalyst grade charcoal in 200 liters of water, in a pressure vessel, and adding thereto 25 liters of 4% (as Pd metal) aqueous palladous chloride. Air is displaced from the vessel and then hydrogen is passed into the aqueous mixture at a pressure of 3 to 5 psi, while stirring, until no further absorption is noted and the chloride is completely reduced to metal.
To the aqueous suspension of the palladized charcoal catalyst thus obtained are added 20.8 kg of 3-cyano-pyridine (96% purity); and then are added 70 liters of a hydrochloric acid solution prepared by diluting 30 liters of 36% HCl with 40 liters of water. This represents approximately 1.75 mols of HCl for each mol of 3-cyano-pyridine. The suspension is maintained at 10° to 15°C and stirred continuously while introducing a current of hydrogen at a pressure of 3 to 5 psi. When absorption of hydrogen ceases and the 3-cyanopyridine is completely reduced, the reaction mixture is filtered to remove the catalyst. The filter cake is washed with 40 liters of water in two equal portions, and the wash water is added to the filtrate.
The combined liquors, which comprise an aqueous hydrochloric acid solution of 3-aminomethyl-pyridine hydrochloride, are then heated to a temperature of 60° to 65°C, and ethyl nitrite gas is passed into the heated solution. The ethyl nitrite is generated by placing 20 liters of 90% ethyl alcohol in a suitable vessel, diluting with 200 liters of water, and, while stirring, adding to the dilute alcohol 18.3 kg of nitrosyl chloride at the rate of 2.25 kg per hour. (The process using methyl nitrite is carried out by substituting a stoichiometrically equivalent quantity of methyl alcohol for the ethyl alcohol.)
When all the ethyl nitrite has been added, the reaction mixture is refluxed for approximately one hour, then concentrated to dryness under reduced pressure (25 to 30 mm Hg) and at a maximum temperature of 70°C. The crystalline residue is dissolved in 35 liters of water and adjusted to a pH of 8 to 9 by addition (with cooling and stirring) of 11 to 12 kg of caustic soda. The sodium chloride formed is filtered off, and the filter cake is washed with 20 liters of normal butyl alcohol. This wash liquid is used for the first extraction of the product from the aqueous filtrate. The filtrate is then further extracted with four successive 20-liter portions of n-butyl alcohol.
All the extracts are combined and concentrated in vacuo (100°C/20 mm) to remove the n-butyl alcohol. The residue is submitted to fractionation under reduced pressure. The forerun (up to 112°C/2 to 3 mm) consists of a small amount of n-butyl alcohol and some 3-pyridylcarbinol. The main fraction, boiling at 112° to 114°C/2 to 3 mm, consists of 3-pyridylcarbinol.

brand name

Roniacol (HoffmannLaRoche).

Therapeutic Function

Vasodilator

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 3261, 1963 DOI: 10.1021/jo01046a538
Synthesis, p. 55, 1987

General Description

3-Pyridinemethanol, an aromatic primary alcohol, is the key moiety of many bio-active and industrially important compounds.

Global( 323)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 19994 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 info@tianfuchem.com China 22021 55
ATK CHEMICAL COMPANY LIMITED
21-51619050 ivan@atkchemical.com China 26815 60
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 13734021967 kaia@neputrading.com CHINA 1011 58
career henan chemical co
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(+1)-858-699-3322 info@accelachem.com United States 19969 58
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18853181302 sale@chuangyingchem.com CHINA 5917 58
Chongqing Chemdad Co., Ltd
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View Lastest Price from 3-Pyridinemethanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-04-18 3-Pyridinemethanol
100-55-0
US $10.00 / L 1L 99% 10tons Henan Guange Biotechnology Co. LTD
2022-03-30 3-Pyridinemethanol
100-55-0
US $10.00 / kg 1kg 0.99 10tons Henan Guange Biotechnology Co. LTD
2022-02-25 3-(Hydroxymethyl)pyridine
100-55-0
US $100.00 / KG 1KG 99 5tons Shanxi Naipu Import and Export Co.,Ltd
3-PYRIDINEMETHANOL 3-Hydroxymethyl pyridine (3-Pyridine methanol) 3-(HYDROXYMETHYL)-PYRIDINE 97% (GC) ω-hydroxy-3-picoline 3-(HYDROXYMETHYL)PYRIDINE 98% 3-HYDROXYMETHYL PYRIDINE PYRIDIN-3-YL-METHANOL PYRIDINE-3-METHANOL (3-PYRIDYLCARBINOL) PHYSICALANDCHEMICALPROPERTIES ω-Hydroxy-3-picoline, 3-(Hydroxymethyl)pyridine, 3-Pyridyl carbinol 3-(Hydroxymethyl)pyridine,98% 3-(HydroxyMethyl)pyridine, 98% 100GR 3-(HydroxyMethyl)pyridine, 98% 5GR 3-Pyridinemethanol,ω-Hydroxy-3-picoline, 3-(Hydroxymethyl)pyridine, 3-Pyridyl carbinol 3-(Hydroxymethyl)pyridine Nicotinyl Alcohol 3-PYRIDYLMETHANOL FOR SYNTHESIS (Pyridin-3-yl)methanol, Nicotinyl alcohol 3-PyridineMethanol 98% beta-Picolyl alcohol beta-picolylalcohol beta-Pyridinecarbinol beta-Pyridylcarbinol Niltuvin (free base) Nu-2121 Pyridine-3-carbinol Pyridyl-3-carbinol Pyridylcarbinol Pyridylmethanol RO-1-5155 Roniacol RONICOL RARECHEM AL BD 0185 PYRIDINE-3-METHANOL NICOTINIC ALCOHOL OMEGA-HYDROXY-3-PICOLINE TIMTEC-BB SBB004344 3-PICOLYL ALCOHOL 3-Pyridinemethanol Vetec(TM) reagent grade, 98% 3-Pyridinemethanol> pyridin-3-ylmethanol hydrochloride 3-Pyridinemethanol 100-55-0 3-Hydroxymethyl pyridine (Pyridine-3-methanol) AI3 11684 AI311684 AI3-11684 3-PYRIDYLMETHANOL 3-Pyridinylmethanol Pyridyl-3-methanol PYRIDIN-3-YLMETHANOL NICOTINYL ALCOHOL 3-(HYDROXYMETHYL)PYRIDINE 3-PYRIDYLCARBINOL 100-55-0 C6H7NO ALCOHOL Building Blocks Heterocyclic Building Blocks Pyridines C6