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ChemicalBook >> CAS DataBase List >>2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Structure
2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID structure
CAS No.
17969-20-9
Chemical Name:
2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID
Synonyms
mialex;8L-323S;ici54,450;Fenclozic;fenclozicacid;acidofenclozico;acidumfenclozicum;Acide p-chlorophenyl-2;2-(p-chlorophenyl)-4-thiazoleaceticaci;2-(4-chlorophenyl)-4-thiazoleaceticaci
CBNumber:
CB6384960
Molecular Formula:
C11H8ClNO2S
Molecular Weight:
253.7
MDL Number:
MFCD00721754
MOL File:
17969-20-9.mol
Last updated:2023-09-20 16:43:00
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2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Properties

Melting point 150-152°C
Boiling point 145°C (rough estimate)
Density 1.2270 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 3.83±0.10(Predicted)
color Off-White to Pale Brown
EWG's Food Scores 1
FDA UNII 58SRQ4DV53

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312
Hazard Codes  Xn
Risk Statements  22
HazardClass  IRRITANT
Toxicity LD50 in rats, mice (mg/kg): 850, 1000 orally; 250, 300 i.v. (Hepworth)

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC F247530 FenclozicAcid 17969-20-9 500mg $275 2021-12-16 Buy
Matrix Scientific 045605 2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid >95% 17969-20-9 500mg $181 2021-12-16 Buy
Matrix Scientific 045605 2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid >95% 17969-20-9 1g $228 2021-12-16 Buy
Biosynth Carbosynth FC124498 [2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid 17969-20-9 100mg $58 2021-12-16 Buy
Biosynth Carbosynth FC124498 [2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid 17969-20-9 250mg $115 2021-12-16 Buy
Product number Packaging Price Buy
F247530 500mg $275 Buy
045605 500mg $181 Buy
045605 1g $228 Buy
FC124498 100mg $58 Buy
FC124498 250mg $115 Buy

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Chemical Properties,Uses,Production

Originator

Fenclozic Acid,ZYF Pharm Chemical

Uses

Fenclozic Acid is a a potent antiinflammatory agent with analgesic and antipyretic properties and is a human hepatotoxic drug.

Manufacturing Process

3.7 parts of 2-(4-chlorophenyl)-4-cyanomethylthiazole and 35 parts of 6 N hydrochloric acid are heated under reflux for 2 hours. The solution is cooled by the addition of ice and made alkaline to pH 8 by the addition of 30% aqueous ammonia. The mixture is filtered to remove trace impurities, and an excess of 40% sodium hydroxide solution is then added to the filtrate to cause precipitation of a sodium salt, which is collected by filtration and crystallised from water. There is thus obtained sodium 2-(4-chlorophenyl)thiazol-4- ylacetate, M.P. 13°C (decomposition).
This sodium salt is dissolved in hot water, and the solution is brought to pH 4 by the addition of acetic acid, which causes the precipitation of 2-(4- chlorophenyl)thiazol-4-ylacetic acid. This is collected by filtration, washed with water, and dried in vacuo over phosphorus pentoxide. It has an M.P. 155- 156°C (from ethyl acetate).

Therapeutic Function

Antiinflammatory, Analgesic, Antipyretic

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Preparation Products And Raw materials

Raw materials

Ammonia Acetic acid Hydrochloric acid

Preparation Products

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Suppliers

Global( 45)Suppliers
Supplier Tel Email Country ProdList Advantage
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006608290; 18621169109 market03@meryer.com China 40241 62
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35906 56
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18216 56
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 3157 55
Supplier Advantage
Career Henan Chemica Co 		58
TargetMol Chemicals Inc. 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Wuhan Chemwish Technology Co., Ltd 56
9ding chemical ( Shanghai) Limited 56
Shanghai Raise Chemical Technology Co.,Ltd 55

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Spectrum

2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID(17969-20-9)1HNMR

17969-20-9(2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID)Related Search:

[2-(3-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID 2-[4-(3-chlorophenyl)-1,3-thiazol-2-yl]acetic acid 2-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]acetic acid [2-(2-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID 2-[2-(4-CHLOROPHENYL)-5-METHYL-1,3-THIAZOL-4-YL]ACETIC ACID
2-(2-METHYL-1,3-THIAZOL-4-YL)ETHANOL 97+% 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID ISOPROPYL 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETATE (2-METHYL-THIAZOL-4-YL)-ACETIC ACID (2-PHENYL-THIAZOL-4-YL)-ACETIC ACID

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2-(4-chlorophenyl)-4-thiazoleaceticaci 2-(4-chlorophenyl)-4-thiazoleaceticacid 2-(4-chlorophenyl)-thiazol-4-ylaceticacid 2-(p-chlorophenyl)-4-thiazoleaceticaci 2-(p-chlorophenyl)-4-thiazole-aceticacid 2-(p-chlorophenyl)thiazol-4-ylaceticacid acidep-chlorophenyl-2thiazole-acetique-4 acidofenclozico acidumfenclozicum fenclozicacid ici54,450 mialex 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID [2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID 2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethanoic acid 2-[2-(4-chlorophenyl)-4-thiazolyl]acetic acid 2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid Fenclozic 4-Thiazoleacetic acid, 2-(4-chlorophenyl)- (9CI) 4-THIAZOLEACETIC ACID, 2-(p-CHLOROPHENYL)- 8L-323S Acide p-chlorophenyl-2 4-Thiazoleacetic acid, 2-(4-chlorophenyl)- [2(4Chlorophenyl)1,3thiazol4yl]acetic acid,[2 (4 Chlorophenyl) 1,3 thiazol 4 yl]acetic acid 17969-20-9