1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE
![1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE Structure](CAS/GIF/110283-66-4.gif)
- CAS No.
- 110283-66-4
- Chemical Name:
- 1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE
- Synonyms
- ci966;CI966HCl;CI 966 hydrochlorid;CI 966 HYDROCHLORIDE;CI-966 hydrochloride (CI966);3-pyridinecarboxylicacid,1,2,5,6-tetrahydro-1-(2-(bis(4-(trifluoromethyl)phen;1-[2-[BIS(4-(TRIFLUOROMETHYL)PHENYL)METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID;1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid hydrochloride;1-[2-bis[4-(Trifluormethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine3-carboxylic acid hydrochloride;1-(2-(Bis(4-(trifluoromethyl)phenyl)methoxy)ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylicacidhydrochloride
- CBNumber:
- CB6386777
- Molecular Formula:
- C23H22ClF6NO3
- Molecular Weight:
- 509.87
- MDL Number:
- MFCD00889186
- MOL File:
- 110283-66-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| CI966hydrochloride ≥98%(HPLC) | 1296 | 10 | $216 |
| CI966hydrochloride ≥98%(HPLC) | 1296 | 50 | $908 |
| CI966Hydrochloride | C475823 | 2.5mg | $235 |
| CI 966 hydrochloride | 254973 | 10mg | $466 |
| CI966hydrochloride | B6677 | 10mg | $314 |
1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE Properties
| Melting point | 240-244 °C |
|---|---|
| storage temp. | Desiccate at RT |
| solubility | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| form | Solid |
| color | White to off-white |
| FDA UNII | MGZ24EM59L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1296 | CI966hydrochloride ≥98%(HPLC) | 110283-66-4 | 10 | $216 | 2021-12-16 | Buy |
| Tocris | 1296 | CI966hydrochloride ≥98%(HPLC) | 110283-66-4 | 50 | $908 | 2021-12-16 | Buy |
| TRC | C475823 | CI966Hydrochloride | 110283-66-4 | 2.5mg | $235 | 2021-12-16 | Buy |
| Usbiological | 254973 | CI 966 hydrochloride | 110283-66-4 | 10mg | $466 | 2021-12-16 | Buy |
| ApexBio Technology | B6677 | CI966hydrochloride | 110283-66-4 | 10mg | $314 | 2021-12-16 | Buy |
1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
CI-966 Hydrochloride is highly selective for the cloned GABA transporter GAT-1. CI 966 Hydrochloride is a GABA transport inhibitor.
Biological Activity
Selective inhibitor of the GABA transporter GAT-1 (IC 50 values are 0.26 and 1.2 μ M at cloned human and rat GAT-1 respectively). Displays over 200-fold selectivity over GAT-2 and GAT-3. Centrally active upon systemic administration in vivo . Anticonvulsive and neuroprotective.
in vivo
CI-966 hydrochloride produces intermediate levels of Pentylenetetrazol (PTZ)-lever responding when administered to PTZ-trained rats[4].
CI-966 hydrochloride enhances gamma-aminobutyric acid action in CA1 pyramidal layer in situ. CI-966 hydrochloride is administered systemically by i.p. injection (5 mg/kg) in Sprague-Dawley rats under urethane anaesthesia. Twenty to thirty minutes after injection there is a highly variable, but overall significant, enhancement of the inhibition of hippocampal population spikes by GABA applied by microiontophoresis in the CA1 region[5].
CI-966 hydrochloride exhibits anticonvulsant properties in various animal models. Oral absorption of CI-966 hydrochloride in dogs given 1.39 mg/kg is rapid with a tmax of 0.7 hr.
In rats given 5 mg/kg oral, a mean tmax of 4.0 hr is observed. Following i.v. administration of the same respective doses, elimination t1/2 in dogs and rats averages 1.2 and 4.5 hr. Absolute oral bioavailability of CI-966 hydrochloride is 100% in both species[6].
| Animal Model: | Eight male Sprague-Dawley rats[4] |
| Dosage: | 0.3-30 mg/kg |
| Administration: | Injection IP in a volume of 1 mL/kg |
| Result: | Dose dependent decreases in rates of responding occurred following CI-966 administration. |
storage
Desiccate at RT
1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 9999 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Hubei Xinyang Medical Technology Co., Ltd | 15347293736 | 2853117764@yongstandards.com | China | 10000 | 58 |
110283-66-4(1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE)Related Search:
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