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1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione

1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione structure

CAS No.: 878983-38-1

Chemical Name:: 1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione

Synonyms: AKOS-22;AKOS 22,AKOS22;1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione;2,5-Pyrrolidinedione, 1-(4-chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]-

CBNumber:: CB63898734

Molecular Formula:: C22H21ClF3N3O3

Molecular Weight:: 467.87

MDL Number:

MOL File:: 878983-38-1.mol

Last updated:2023-06-30 15:45:59

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1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione Properties

storage temp.	Store at -20°C
solubility	DMSO: 125 mg/mL (267.17 mM)

1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione Chemical Properties,Uses,Production

Biological Activity

AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction[1].

storage

Store at -20°C

References

[1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protectagainst Mitochondrial Dysfunction. Biol Chem. 2016 Nov 25;291(48):24986-25003.

1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7984	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shanghai EFE Biological Technology Co., Ltd.	58
Changzhou Furuisi Biotechnology Co., Ltd	58
Beijing Biocreative Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Yiyan Biotechnology Co. , Ltd.	58

1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione AKOS-22 2,5-Pyrrolidinedione, 1-(4-chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]- AKOS 22,AKOS22 878983-38-1