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Ketorolac

Chemical properties Pharmacological action
Ketorolac
Ketorolac
CAS No.
74103-06-3
Chemical Name:
Ketorolac
Synonyms
Dolac;Acular;rs37619;Lixidol;Tm-asyn;Toratex;Fluoxetin;KETOROLAC;Ketoralac;KETOROLAC-D5
CBNumber:
CB6392833
Molecular Formula:
C15H13NO3
Formula Weight:
255.27
MOL File:
74103-06-3.mol

Ketorolac Properties

Melting point:
160-161°C
pka
3.49 ±0.02(at 25℃)
CAS DataBase Reference
74103-06-3(CAS DataBase Reference)

SAFETY

RIDADR  3249
HazardClass  6.1(a)
PackingGroup  II
Toxicity LD50 orally in mice: ~200 mg/kg (Rooks)

Ketorolac price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 9001148 Ketorolac ≥95% 74103-06-3 50mg $10 2018-11-19 Buy
Cayman Chemical 9001148 Ketorolac ≥95% 74103-06-3 100mg $14 2018-11-19 Buy
Cayman Chemical 9001148 Ketorolac ≥95% 74103-06-3 500mg $64 2018-11-19 Buy
Cayman Chemical 9001148 Ketorolac ≥95% 74103-06-3 1g $89 2018-11-19 Buy

Ketorolac Chemical Properties,Uses,Production

Chemical properties

It is crystallized in ethyl acetate - ether with a melting point of 160~161 degrees centigrade.The maximum absorption of UV (methanol):245,312m (epsilon 7080,17400). PKa3.49 + 0.02.Acute toxic LD50 mice (mg/kg): about 200 of oral administration. .(+) - configuration: crystallized from hexane ethyl acetate with the melting point of 174 degrees centigrade;The melting point is 154 156 degrees centigrade. [α]D+173° (C=1, methanol).(-) - configuration: crystallizzed from hexane ethyl acetate with melting point at 169~170 degrees centigrade; melting point is 153~155 degrees centigrade. [α]D-176° (C=1, methanol).

Pharmacological action

Ketorolac is also called ketorolac, acular and Ketorolac Tromethamine. It is a non steroid analgesic and anti-inflammatory drug, a derivative of pyrrolidone.The chemical structure and pharmacological action is similar to Tolectin, Zoaesthetic acid and Indometacin. By inhibiting cyclooxygenase, it inhibits the synthesis and release of prostaglandins, and produces anti-inflammatory effects. It can reduce the temperature induced by heat source, which is related to the inhibition of the synthesis of prostaglandin in the central nervous system.It has strong analgesic and moderate anti-inflammatory antipyretic and inhibition of platelet aggregation, and has no inhibition of respiration and addiction. In animal experiments, the analgesic effect is stronger than aspirin, indomethacin and naproxen.It is equal to or better than the anti-inflammatory effect of naproxen and indomethacin, phenylbutazone,Its antipyretic effect on rats are stronger than aspirin and phenylbutazone and the same with indomethacin and naproxen.It inhibits the platelet aggregation induced by arachidonic acid and collagen.But it does not inhibit the induction of adenosine diphosphate(ADP) ..This product is quickly and completely absorbed after the intramuscular injection, and is almost completely absorbed after oral administration.Food can slow down the absorption speed, but it does not affect the degree of absorption, and the bioavailability is 80% ~ 100%. 10 minutes after intramuscular injection of 30mg, it usually relieves the pain obviously. After 50 minutes, the peak of plasma concentration is up to 2.2 g/mL.After 30~60 minutes of oral administration, the pain is obviously relieved and the concentration of plasma is peak at 1.5 to 4 hours.The plasma half-life of young people is about 5.3 hours, and for the elderly it is about 7 hours, and the analgesic effect could be maintained for 6~8 hours. 91.4% will be excreted from the urinary tract, the rest will be excreted from the excrement.In patients with renal insufficiency, the total plasma clearance rate decreases and the half-life prolongs, so the dosage should be reduced.
Clinical application: ketorolac is mainly used for short-term pain treatment including postoperative pain (such as the abdomen, chest, Urology, gynecology, Department of Stomatology, orthopedic surgery and pain) as well as the acute skeletal muscle pain caused by various causes, such as sprain, dislocation, fracture and soft tissue injury, and other pain caused by other diseases, such as postpartum pain, acute renal colic, toothache, sciatica, late cancer pain, wound pain, biliary colic, etc.. It can be used as a substitute for morphine and pethidine.

Chemical Properties

Light yellow solid

Uses

antiarrhythmic

Uses

prostaglandin F2a analogue

brand name

Acular (Allergan); Toradol (Roche).

Ketorolac Preparation Products And Raw materials

Raw materials

Preparation Products


Ketorolac Suppliers

Global( 99)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 2515 58
Shanghai Renshi Pharmatech Co., LTD 021-26018649, 17721318029 QQ:2899427924
021-26018649 info@renshipharma.com China 70 55
parabiochem 025-83453382-8005
025-83453382 sale@parabiochem.com China 9622 55
INTATRADE GmbH +49 3493/605464
+49 3493/605470 sales@intatrade.de Germany 3587 66
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 13582355795
4000311741 master@sjzsdyn.com China 4912 65

74103-06-3(Ketorolac)Related Search:


  • 3-dihydro-5-benzoyl-(+-)-1h-pyrrolizine-1-carboxylicaci
  • rs37619
  • 5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid
  • KETOROLAC
  • KETOROLAC-D5
  • KETOROLAC TROMETHAMINE, USP STANDARD
  • 5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-ca
  • Ketoralac
  • 3-dihydro-5-benzoyl- (+-)-1h-pyrrolizine-1-carboxylic acid
  • Fluoxetin
  • Acular
  • Dolac
  • Lixidol
  • Tm-asyn
  • Toratex
  • (1S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • (1S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1β-carboxylic acid
  • (S)-Ketorolac
  • Ketorolac acid
  • 5-phenylcarbonyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • Ketorolac-13C6
  • 74103-06-3
  • C15H8NO3D5
  • API's
  • Other APIs
  • C913C6H13NO3
  • Ketorolac Solution, 100ppm
  • Ketorolac, >=98%
  • (1RS)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
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