STREPTOLYSIN O
- CAS No.
- 98072-47-0
- Chemical Name:
- STREPTOLYSIN O
- Synonyms
- STREPTOLYSIN O;Einecs 308-500-3;Streptococcus sp.;STREPTOLYSIN O REAGENT;STREPTOLYSIN O GAMMA-IRRADIATED;Hemolysins O, Streptococcus group A;STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES;Native Streptococcus pyogenes Streptolysin O
- CBNumber:
- CB6407012
- Molecular Formula:
- NULL
- Molecular Weight:
- 0
- MDL Number:
- MFCD00132389
- MOL File:
- Mol file
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: soluble1mg/mL |
| form | lyophilized powder |
| color | white |
| EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310+H330 |
| Precautionary statements | P260-P262-P264-P280-P302+P352+P310-P304+P340+P310 |
| RIDADR | UN 2811PIH 6.1 / PGI |
| WGK Germany | 3 |
STREPTOLYSIN O price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S5265 | Streptolysin O from Streptococcus pyogenes lyophilized powder, Protein ~3?% by Lowry, 25,000-50,000?U/vial | 98072-47-0 | 25000units | $240 | 2024-03-01 | Buy |
| Sigma-Aldrich | S0149 | Streptolysin O from Streptococcus pyogenes γ-irradiated | 98072-47-0 | 25000units | $282 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAE0089 | Streptolysin O from Streptococcus pyogenes ≥1,000,000?units/mg protein, recombinant, lyophilized powder, expressed in E. coli | 98072-47-0 | 100KU | $206 | 2023-06-20 | Buy |
| Usbiological | 506381 | Streptolysin O | 98072-47-0 | 1mg | $472 | 2021-12-16 | Buy |
| Usbiological | 506380 | Streptolysin O | 98072-47-0 | 1mg | $472 | 2021-12-16 | Buy |
STREPTOLYSIN O Chemical Properties,Uses,Production
Uses
Used to create holes (reversible pores) in cholesterol-enriched plasma membranes of eukaryotic cells allowing selective permeabilization with molecules such as proteins (up to 100 kDa) and siRNAs.
Uses
Permeabilizes membranes to permit cellular uptake of large or charged molecules.
General Description
Streptolysin O (SLO) is an immunogenic, oxygen-labile toxin, hemolytic exotoxin which is reversibly activated by dithiothreitol. [1] It is released into the extracellular medium along with other toxins, including streptolysin S, during the growth of most strains of group A and many strains of groups C and G Streptococci. [1,2] SLO and Streptolysin S differ from each other in that SLO is immunogenic and oxygen-labile while Streptolysin S is oxygen-stable, nonimmunogenic and only active when associated with a carrier protein.[3] The hemolytic activity of SLO is mediated by formation of multimeric nanopores in cholesterol containing lipid membranes.
SLO may be used for cell permeabilization or hemolysis. The susceptibility of hemolysis by SLO varies significantly for erythrocytes from different animal species.[1] Permeabilization of cells using SLO has been performed on multiple cell types and for various applications. For instance it has been used to introduce antisense oligonucleotides into cultured eukaryotic cells;[3] to investigate the effect of guanine nucleotide analogues on phosphatidylinositol metabolism and protein kinase C (PKC) activation in live human T lymphocytes;[4] to monitor cholesterol oxidation within a membrane lipid bilayer; [5] and to label proteins inside living cells using external fluorophores.[6]
Biochem/physiol Actions
This product is produced by recombinant expression in Escherichia coli and contains the complete native protein sequence of SLO (Uniport ID: P0DF96 aa 34-571) without any added purification tags and has calculated molecular weight of 60,144 Dalton. The material is lyophilized from a solution containing 20 mM Sodium Hepes pH 7.5, 150 mM Sodium Chloride and 2 mM EDTA.
STREPTOLYSIN O Preparation Products And Raw materials
Raw materials
Preparation Products
STREPTOLYSIN O Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Duly Biotech Co.,Ltd | +undefined18013301590 | melody@njduly.com | China | 2452 | 58 |
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; | market@aladdin-e.com | China | 25004 | 65 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003 18013301590 | njduly@126.com | China | 973 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15878 | 55 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9972 | 58 |
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