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Meglumine

Meglumine
Meglumine structure
CAS No.
6284-40-8
Chemical Name:
Meglumine
Synonyms
MeguMine;Meglumin;C7H18NO5;MEGLUMINE;N-Methyl-D-Glu;MEGLUMINE, USP;MegluMine (AS);Methylglucamin;Methylglucamine;N-METHYLGLUCAMINE
CBNumber:
CB6411710
Molecular Formula:
C7H17NO5
Formula Weight:
195.21
MOL File:
6284-40-8.mol

Meglumine Properties

Melting point:
129-131.5 °C(lit.)
alpha 
-16.5 º (c=10, H2O, on dry sub)
Boiling point:
331.88°C (rough estimate)
Density 
1.2669 (rough estimate)
refractive index 
-16.5 ° (C=2, H2O)
RTECS 
LZ4295770
storage temp. 
Store below +30°C.
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
Crystalline Powder
pka
pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
color 
White to almost white
PH
11 (10g/l, H2O, 20℃)
optical activity
[α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility 
100 g/100 mL (25 ºC)
Sensitive 
Air Sensitive & Hygroscopic
Merck 
14,6078
BRN 
385906
InChIKey
MBBZMMPHUWSWHV-VZFHVOOUSA-N
NIST Chemistry Reference
N-methylglucamine(6284-40-8)
EPA Substance Registry System
D-Glucitol, 1-deoxy-1-(methylamino)-(6284-40-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Risk Statements  36/37/38
Safety Statements  24/25
WGK Germany  3
3-10-23
Autoignition Temperature ~662 °F
TSCA  Yes
HS Code  29221980
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Meglumine price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 66930 N-Methyl-D-glucamine ReagentPlus , ≥99.0% (T) 6284-40-8 100g $32 2018-11-13 Buy
Sigma-Aldrich 1379140 Meglumine United States Pharmacopeia (USP) Reference Standard 6284-40-8 500mg $348 2018-11-13 Buy
TCI Chemical M0227 N-Methyl-D-glucamine >99.0%(T) 6284-40-8 25g $17 2018-11-22 Buy
TCI Chemical M0227 N-Methyl-D-glucamine >99.0%(T) 6284-40-8 500g $73 2018-11-22 Buy
Alfa Aesar L14282 N-Methyl-D-glucamine, 99% 6284-40-8 50g $19.5 2018-11-13 Buy

Meglumine Chemical Properties,Uses,Production

Chemical Properties

white to almost white crystalline powder

Chemical Properties

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.

Uses

antiinflammatory

Uses

excipient in cosmetics and X-ray contrast media

Definition

ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.

Production Methods

Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.

brand name

Renovue (Bracco).

Pharmaceutical Applications

Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.

Safety

Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg

storage

Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.

Purification Methods

Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]

Incompatibilities

Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.

Regulatory Status

Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.

Meglumine Preparation Products And Raw materials

Raw materials

Preparation Products


Meglumine Suppliers

Global( 335)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhengzhou Yuanli Biological Technology Co., Ltd
0086-371-67897895
info@zzyuanli.cn CHINA 133 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19917 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3202 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21759 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1849 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58

View Lastest Price from Meglumine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-07 Meglumine
6284-40-8
US $1.00 / KG 1KG 99% Customized career henan chemical co

Meglumine Spectrum


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