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Meglumine

Meglumine
Meglumine structure
CAS No.
6284-40-8
Chemical Name:
Meglumine
Synonyms
-D-gL;ucamine;Meglumin;C7H18NO5;MeguMine;MEGLUMINE;Meglumine CRS;Methylglucamin;N-Methyl-D-Glu;MEGLUMINE, USP
CBNumber:
CB6411710
Molecular Formula:
C7H17NO5
Formula Weight:
195.21
MOL File:
6284-40-8.mol

Meglumine Properties

Melting point:
129-131.5 °C (lit.)
alpha 
-16.5 º (c=10, H2O, on dry sub)
Boiling point:
331.88°C (rough estimate)
Density 
1.2669 (rough estimate)
RTECS 
LZ4295770
refractive index 
-16.5 ° (C=2, H2O)
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless
pka
pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
form 
Crystalline Powder
color 
White to almost white
PH
11 (10g/l, H2O, 20℃)
optical activity
[α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility 
100 g/100 mL (25 ºC)
Sensitive 
Air Sensitive & Hygroscopic
Merck 
14,6078
BRN 
385906
InChIKey
MBBZMMPHUWSWHV-VZFHVOOUSA-N
EWG's Food Scores
1
FDA UNII
6HG8UB2MUY
NIST Chemistry Reference
N-methylglucamine(6284-40-8)
EPA Substance Registry System
Meglumine (6284-40-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Risk Statements  36/37/38
Safety Statements  24/25
WGK Germany  3
3-10-23
Autoignition Temperature ~662 °F
TSCA  Yes
HS Code  29221980
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
NFPA 704
0
0 1

Meglumine price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 66930 N-Methyl-D-glucamine ReagentPlus , ≥99.0% (T) 6284-40-8 100g $37.8 2020-08-18 Buy
Sigma-Aldrich Y0001209 Meglumine European Pharmacopoeia (EP) Reference Standard 6284-40-8 $190 2021-03-22 Buy
Sigma-Aldrich 8.18318 D(-)-N-Methylglucamine for resolution of racemates for synthesis 6284-40-8 250 g $53.37 2021-03-22 Buy
Sigma-Aldrich 1379140 Meglumine United States Pharmacopeia (USP) Reference Standard 6284-40-8 500mg $366 2021-03-22 Buy
TCI Chemical M0227 N-Methyl-D-glucamine >99.0%(T) 6284-40-8 25g $17 2021-03-22 Buy

Meglumine Chemical Properties,Uses,Production

Chemical Properties

white to almost white crystalline powder

Chemical Properties

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.

Uses

antiinflammatory

Uses

excipient in cosmetics and X-ray contrast media

Definition

ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.

Production Methods

Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.

brand name

Renovue (Bracco).

Pharmaceutical Applications

Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.

Safety

Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg

storage

Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.

Purification Methods

Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]

Incompatibilities

Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.

Regulatory Status

Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.

Meglumine Preparation Products And Raw materials

Raw materials

Preparation Products


Meglumine Suppliers

Global( 484)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhengzhou Yuanli Biological Technology Co., Ltd
0086-371-67897895
info@zzyuanli.cn CHINA 136 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17607 58
Wuhan wingroup Pharmaceutical Co., Ltd
0086-18062075862
0086-27-87819568 admin@whwingroup.com CHINA 2478 58
GZ HONCH CHEMICAL TECHNOLOGY CO.,LTD
+8613437848121
+8613437848121 chemicalbest@foxmail.com CHINA 222 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58

View Lastest Price from Meglumine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-15 Meglumine
6284-40-8
US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.
2021-10-15 Meglumine
6284-40-8
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-10-14 N-methylglucamine
6284-40-8
US $10.00 / GK 1KG 99% 20 tons Hebei Dongdu Import and Export Co. LTD

Meglumine Spectrum


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