Meglumine
- CAS No.
- 6284-40-8
- Chemical Name:
- Meglumine
- Synonyms
- N-METHYL-D-GLUCAMINE;N-METHYLGLUCAMINE;Meglumin;Methylglucamine;1-deoxy-1-(methylamino)-d-glucito;MeguMine;Meglumine CRS;Methylglucamin;D(-)-N-METHYLGLUCAMINE;1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
- CBNumber:
- CB6411710
- Molecular Formula:
- C7H17NO5
- Molecular Weight:
- 195.21
- MDL Number:
- MFCD00004707
- MOL File:
- 6284-40-8.mol
- MSDS File:
- SDS
| Melting point | 129-131.5 °C (lit.) |
|---|---|
| Boiling point | 331.88°C (rough estimate) |
| alpha | -16.5 º (c=10, H2O, on dry sub) |
| Density | 1.2669 (rough estimate) |
| RTECS | LZ4295770 |
| refractive index | -16.5 ° (C=2, H2O) |
| storage temp. | 2-8°C |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| pka | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
| color | White to almost white |
| PH | 11 (10g/l, H2O, 20℃) |
| optical activity | [α]20/D 16.5±0.5°, c = 2% in H2O |
| Water Solubility | 100 g/100 mL (25 ºC) |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 14,6078 |
| BRN | 385906 |
| InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
| LogP | -3.370 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | 6HG8UB2MUY |
| NIST Chemistry Reference | N-methylglucamine(6284-40-8) |
| EPA Substance Registry System | Meglumine (6284-40-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10-23 | |||||||||
| Autoignition Temperature | ~662 °F | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29221980 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg | |||||||||
| NFPA 704 |
|
Meglumine price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 66930 | N-Methyl-D-glucamine ReagentPlus , ≥99.0% (T) | 6284-40-8 | 100g | $67.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.18318 | D(-)-N-Methylglucamine for resolution of racemates for synthesis | 6284-40-8 | 250g | $72.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1379140 | Meglumine United States Pharmacopeia (USP) Reference Standard | 6284-40-8 | 500mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1.06143 | Meglumine low in endotoxins, EMPROVE? API, Ph. Eur., ChP, JP, USP | 6284-40-8 | 1KG | $244 | 2022-05-15 | Buy |
| Sigma-Aldrich | 1.06187 | Meglumine EMPROVE? ESSENTIAL, Ph. Eur., ChP, JP, USP | 6284-40-8 | 1KG | $244 | 2022-05-15 | Buy |
Meglumine Chemical Properties,Uses,Production
Chemical Properties
white to almost white crystalline powder
Chemical Properties
Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.
Uses
antiinflammatory
Uses
N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.
Uses
excipient in cosmetics and X-ray contrast media
Production Methods
Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.
Definition
ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.
brand name
Renovue (Bracco).
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.
Pharmaceutical Applications
Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.
Safety
Meglumine is widely used in parenteral pharmaceutical formulations
and is generally regarded as a nontoxic material at the levels
usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg
storage
Meglumine does not polymerize or dehydrate unless heated above
150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a
cool, dry place. Meglumine should not be stored in aluminum
containers since it reacts to evolve hydrogen gas; it discolors if
stored in containers made from copper or copper alloys. Stainless
steel containers are recommended.
Purification Methods
Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]
Incompatibilities
Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.
Regulatory Status
Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.
Meglumine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Wuhan Silworld Chemical Co.,Ltd | +86-027-85613400 +86-15827173649 | info@silworldchemical.com | China | 178 | 58 |
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 | sales001@rokechem.com | China | 255 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | hbjbtech@163.com | China | 1000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7473 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 524 | 58 |
| Shanghai Aosiris new Material Technology Co., LTD | +8615139564871 | wrjmoon2000@163.com | China | 354 | 58 |
| Shijiazhuang Jianxin Biotechnology Co., LTD | +undefined+86-17692708569 | liyingjian1997@gmail.com | China | 787 | 58 |
View Lastest Price from Meglumine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Meglumine
6284-40-8
|
US $3.00-1.00 / kg | 1kg | 99.9% | 10 tons | Shanghai Aosiris new Material Technology Co., LTD | |
 |
2024-03-29 | Meglumine
6284-40-8
|
US $8.00-1.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-03-24 | Meglumine
6284-40-8
|
US $100.00-15.00 / kg | 1kg | 99% | 20MT/Month | Shijiazhuang Jianxin Biotechnology Co., LTD |
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