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Lycorine hydrochloride

CAS No.
2188-68-3
Chemical Name:
Lycorine hydrochloride
Synonyms
LYCORIN;LYCORINE;NARCISSIN(P);(-)-LYCORINE;Lycorine chloride;Hydrochloric Lycorine;Licorin hydrochloride;Lycorine hydrochloride;Licorine hydrochloride;Amarylline hydrochloride
CBNumber:
CB6415905
Molecular Formula:
C16H17NO4
Molecular Weight:
287.31
MDL Number:
MFCD00243111
MOL File:
2188-68-3.mol
MSDS File:
SDS
Last updated:2024-01-04 11:05:11

Lycorine hydrochloride Properties

Melting point 206 °C
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Soluble in water (15 mg/ml)
form powder
color White to off-white
Stability Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
FDA UNII 58F70VH0HS

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P405-P501
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3

Lycorine hydrochloride price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L5139 Lycorine hydrochloride ≥98% (TLC), powder 2188-68-3 20mg $360 2024-03-01 Buy
TRC L487550 Lycorine hydrochloride 2188-68-3 20mg $110 2021-12-16 Buy
TRC L487550 Lycorine hydrochloride 2188-68-3 50mg $150 2021-12-16 Buy
Usbiological 300599 Lycorine hydrochloride 2188-68-3 20mg $263 2021-12-16 Buy
ChemScene CS-5954 Lycorine hydrochloride 99.89% 2188-68-3 100mg $264 2021-12-16 Buy
Product number Packaging Price Buy
L5139 20mg $360 Buy
L487550 20mg $110 Buy
L487550 50mg $150 Buy
300599 20mg $263 Buy
CS-5954 100mg $264 Buy

Lycorine hydrochloride Chemical Properties,Uses,Production

Description

Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5

Uses

Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.

Biochem/physiol Actions

A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.

References

Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168 Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483 Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407 Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174 Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1

Lycorine hydrochloride Preparation Products And Raw materials

Global( 271)Suppliers
Supplier Tel Email Country ProdList Advantage
Chongqing Zhihe Biopharmaceutical Co., Ltd.
+86-18580541567 +86-17782035140 sales@zhswyy.com China 382 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897 sales@biopurify.com China 3424 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768 sales@dolonchem.com CHINA 2972 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
+8613815430202 sale02@cqherb.com CHINA 376 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shanghai Standard Technology Co., Ltd.
18502101150 ft-sales@nature-standard.com CHINA 1923 58

View Lastest Price from Lycorine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lycorine hydrochloride pictures 2024-03-08 Lycorine hydrochloride
2188-68-3
US $0.00-0.00 / kg 0.10000000149011612kg ≥98% 20tons Chongqing Zhihe Biopharmaceutical Co., Ltd.
Lycorine hydrochloride pictures 2024-03-01 Lycorine hydrochloride
2188-68-3
US $0.00 / KG 1KG 98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
Lycorine hydrochloride pictures 2023-06-15 Lycorine hydrochloride
2188-68-3
US $3175.00 / KG 1KG 98% 1000kg Baoji Guokang Bio-Technology Co., Ltd.

Lycorine hydrochloride Spectrum

Lycorine Hydrochloride98% Licorin hydrochloride Hydrochloric Lycorine LYCORIN (-)-LYCORINE LYCORINE NARCISSIN(P) (1S,2S,12BS,12CS)-1,2,4,5,12B,12C-HEXAHYDRO-7H-[1,3]DIOXOLO[4,5-J]PYRROLO[3,2,1-DE]PHENANTHRIDINE-1,2-DIOL Lycorine hydrochloride Lycorine chloride Lycorinehydrochloride 2188-68-3 Lycorine chloride 2188-68-3 Lycorine hydrochloride, 96%(HPLC) Amarylline hydrochloride Galanthidine hydrochloride Licorine hydrochloride Narcissine hydrochloride Lycorine hydrochloride USP/EP/BP (1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)- (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride (1:1) (1R,17S,18R,19S)-5,7-Dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol 2188-68-3 C16H17NO4HCl Cell Signaling and Neuroscience Cell Biology BioChemical Gene Regulation and Expression RNA-Protein Translation Inhibitors Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Peptidyl transferaseCell Signaling and Neuroscience Enzyme Inhibitors by Enzyme Gene Regulation and Expression P to RNA-Protein Translation Inhibitors