Lycorine hydrochloride
- CAS No.
- 2188-68-3
- Chemical Name:
- Lycorine hydrochloride
- Synonyms
- LYCORIN;LYCORINE;NARCISSIN(P);(-)-LYCORINE;Lycorine chloride;Hydrochloric Lycorine;Licorin hydrochloride;Lycorine hydrochloride;Licorine hydrochloride;Amarylline hydrochloride
- CBNumber:
- CB6415905
- Molecular Formula:
- C16H17NO4
- Molecular Weight:
- 287.31
- MDL Number:
- MFCD00243111
- MOL File:
- 2188-68-3.mol
- MSDS File:
- SDS
Melting point | 206 °C |
---|---|
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | Soluble in water (15 mg/ml) |
form | powder |
color | White to off-white |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month. |
FDA UNII | 58F70VH0HS |
Lycorine hydrochloride price More Price(37)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | L5139 | Lycorine hydrochloride ≥98% (TLC), powder | 2188-68-3 | 20mg | $360 | 2024-03-01 | Buy |
TRC | L487550 | Lycorine hydrochloride | 2188-68-3 | 20mg | $110 | 2021-12-16 | Buy |
TRC | L487550 | Lycorine hydrochloride | 2188-68-3 | 50mg | $150 | 2021-12-16 | Buy |
Usbiological | 300599 | Lycorine hydrochloride | 2188-68-3 | 20mg | $263 | 2021-12-16 | Buy |
ChemScene | CS-5954 | Lycorine hydrochloride 99.89% | 2188-68-3 | 100mg | $264 | 2021-12-16 | Buy |
Lycorine hydrochloride Chemical Properties,Uses,Production
Description
Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
Uses
Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.
Biochem/physiol Actions
A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.
References
Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168 Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483 Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407 Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174 Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1
Lycorine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 338 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
View Lastest Price from Lycorine hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-26 | Lycorine hydrochloride
2188-68-3
|
US $0.00-0.00 / kg | 0.10000000149011612kg | ≥98% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | ||
2024-04-23 | Lycorine hydrochloride
2188-68-3
|
US $0.00 / KG | 1KG | 98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
2023-06-15 | Lycorine hydrochloride
2188-68-3
|
US $3175.00 / KG | 1KG | 98% | 1000kg | Baoji Guokang Bio-Technology Co., Ltd. |
- Lycorine hydrochloride
2188-68-3
- US $0.00-0.00 / kg
- ≥98%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
- Lycorine hydrochloride
2188-68-3
- US $0.00 / KG
- 98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
- Lycorine hydrochloride
2188-68-3
- US $3175.00 / KG
- 98%
- Baoji Guokang Bio-Technology Co., Ltd.