15-28-Somatostatin-28

15-28-Somatostatin-28 Properties

Melting point	>211°C (dec.)
Boiling point	1970.9±65.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	H₂O: 1 mg/mL
form	powder
pka	2.94±0.70(Predicted)
color	White to Off-White
Water Solubility	Soluble in water(25,00°C 1,00 g/L), Methanol.
Merck	13,8788
BRN	6436064
Sequence	Ala-Gly-c[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]-OH,(Disulfide bridge: Cys-Cys)
InChIKey	NHXLMOGPVYXJNR-ATOGVRKGSA-N
EWG's Food Scores	1
FDA UNII	6E20216Q0L

SAFETY

Risk and Safety Statements

WGK Germany	3
RTECS	WF8751700
F	3-10-21

15-28-Somatostatin-28 price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S9129	Somatostatin ≥97%(HPLC),powder	38916-34-6	0.5mg	$95	2024-03-01	Buy
Sigma-Aldrich	S1763	Somatostatin powder,BioReagent,suitableforcellculture	38916-34-6	0.1mg	$59.1	2024-03-01	Buy
Sigma-Aldrich	S0885	Somatostatin powder,γ-irradiated,BioXtra,suitableforcellculture	38916-34-6	20μg	$40.68	2024-03-01	Buy
Alfa Aesar	J66168	Somatostatin 14	38916-34-6	5mg	$157	2023-06-20	Buy
Sigma-Aldrich	S9129	Somatostatin ≥97% (HPLC), powder	38916-34-6	1mg	$108	2024-03-01	Buy

Product number	Packaging	Price	Buy
S9129	0.5mg	$95	Buy
S1763	0.1mg	$59.1	Buy
S0885	20μg	$40.68	Buy
J66168	5mg	$157	Buy
S9129	1mg	$108	Buy

15-28-Somatostatin-28 Chemical Properties,Uses,Production

Chemical Properties

White Powder

Uses

Growth hormone-release inhibiting factor; treatment of severe, acute hemorrhage of gastroduodenal ulcers; experimental antidiabetic.

Definition

ChEBI: A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.

Biological Functions

Somatostatin is a cyclic 14-peptide that was first isolated by Guillemin in 1973 and is probably the most thoroughly investigated and most important of the inhibitory factors produced by the hypothalamus. The principal activity of somatostatin, which is of hypothalamic origin, is inhibition of the release of growth hormone (GH) from the anterior pituitary. Too much GH, as in pituitary tumors, causes acromegaly, a form of giantism. On the other hand, too little GH leads to dwarfism. Somatostatin also has been found in the pancreas and the GI tract, where it inhibits the secretion of both insulin and glucagon from the pancreas as well as the secretion of a variety of intestinal peptides (e.g., gastrin, secretin, pepsin, and renin). The short half-life of somatostatin, which is less than 3 minutes, has precluded its use as a therapeutic agent. Many derivatives of somatostatin have been prepared to increase its duration of action and/or to enhance its selectivity of action. The culmination of these structure–activity studies was the development of octreotide acetate.

General Description

Somatostatin (SST) is a peptide.

Biochem/physiol Actions

Somatostatin regulates the secretion of hormones and bioactive peptides. It acts as an inhibitor in the digestive tract by inhibiting gastrin release. In the pancreatic islets, it inhibits glucagon and insulin release. Somatostatin and its synthetic analogs have been used in the treatment of neuroendocrine tumors.

Purification Methods

Somatostatin is a tetradecapeptide which is purified by gel filtration on Sephadex G-25, eluting with 2N AcOH, and then by liquid partition chromatography on Sephadex G-25 using n-BuOH/AcOH/H2O (4:1:5) and has RF = 0.4. It is a brain growth hormone releasing-inhibiting factor which has also been synthesised. [Burgus et al. Proc Natl Acad Sci USA 70 684 1973, Sorantakis & McKinley Biochem Biophys Res Commun 54 234 1973, Hartridt et al. Pharmazie 37 403 1982.]

15-28-Somatostatin-28 synthesis

Synthesis of 15-28-Somatostatin-28 from dihydrosomatostatin

15-28-Somatostatin-28 Preparation Products And Raw materials

Raw materials

L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-L-alanylglycyl-L-cysteinyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-N-(triphenylmethyl)-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-1-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-O-(1,1-dimethylethyl)-L-threonyl-L-phenylalanyl-O-(1,1-dimethylethyl)-L-threonyl-O-(1,1-dimethylethyl)-L-seryl-, [3,4,5-tris(octadecyloxy)phenyl]methyl ester, cyclic (3→14)-disulfide dihydrosomatostatin

Preparation Products

15-28-Somatostatin-28 Suppliers

Global( 311)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Rixing Chemical CO.,LTD	+86-13237129059 -13237129059	sales@rixingchemi.com	CHINA	229	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58

Supplier	Advantage
Cellmano Biotech Limited	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Alpha Biopharmaceuticals Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Rixing Chemical CO.,LTD	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

View Lastest Price from 15-28-Somatostatin-28 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-08	Somatostatin-14 38916-34-6	US $10.00 / kg	1kg	99%	1000kg	Nantong Guangyuan Chemicl Co,Ltd
2024-01-02	15-28-Somatostatin-28 38916-34-6	US $65.00-650.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2022-10-12	15-28-Somatostatin-28 38916-34-6	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

Somatostatin-14
38916-34-6
US $10.00 / kg
99%
Nantong Guangyuan Chemicl Co,Ltd

15-28-Somatostatin-28
38916-34-6
US $65.00-650.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

15-28-Somatostatin-28
38916-34-6
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

15-28-Somatostatin-28 Spectrum

15-28-Somatostatin-28(38916-34-6)MS

38916-34-6(15-28-Somatostatin-28)Related Search:

SOMATOSTATIN 28, CYCLIC Somatostatin Oxytocin Bivalirudin H-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH

H-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH H-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-OH H-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-OH SOMATOSTATIN-28 (1-14) SOMATOSTATIN-28 (1-12)

SOMATOSTATIN-25 SOMATOSTATIN 28 Hexarelin Growth hormone releasing peptide 15-28-Somatostatin-28

GROWTH HORMONE, HUMAN TYR-SOMATOSTATIN-28 AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14), ACETATE SALT

1of4

AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14) SOMATOSTATIN-14 SOMATOSTATIN-14 (COUPLED TO BSA) SOMATOSTATIN-14 (COUPLED TO KLH) SOMATOSTATIN-14 (REDUCED) SOMATOSTATIN ACETATE SOMATOSTATIN, CYCLIC SOMATOSTATIN [D-TRP8] SOMATOSTATIN [GIF] SOMATOSTATIN (HUMAN, OVINE, PORCINE, RAT, MOUSE) SOMATOSTATIN (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O SOMATOSTATIN, SHEEP SOMATOSTATIN [TYR1] SOMATOTROPIN RELEASE INHIBITING FACTOR SOMATOTROPIN RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) SOMATOTROPIN RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O SRIF Growth hormone-release inhibiting factor: L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide Somatostatina Somatostatina [inn-spanish] Somatostatine Growth hormone release inhibiting factor Somatotropin release inhibiting factor SRIF (HUMAN, OVINE, PORCINE, RAT, MOUSE) SRIF (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bond) somatostatin gamma-irradiated*cell culture tested SOMATOSTATIN, CELL CULTURE TESTED Growth hormone-releasing inhibiting factor Argirelin Acetate Somastostatin Acetate Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, (Disulfide Bridge3:14) 15-28-Somatostatin-28 Synthetic cyclic growth hormone release-inhibiting factor Synthetic somatostatin-14 Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge Cys3-Cys14) H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH acetate salt (Disulfide bond) SOMATOSTATIN PH. EUR. Aminopan Modustatina Somatofalk SRIF-A Stilamin Growth hormone release inhibiting factor, Somatostatin-14, Somatotropin release inhibiting factor, SRIF Somatostatin【rat】 SS-14 ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS: AGCKNFFWKTFTSC DISULFIDE BRIDGE CYS3-CYS14 Einecs 254-186-5 Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH SoMatotropin Release-Inhibiting Factor, SRIF, SRIF-14 Cyclic somatostatin SoMatostatin Acetat GROWTH HORMONE RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) GROWTH HORMONE RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (COUPLED TO BSA) H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (COUPLED TO KLH) H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH, CYS3,14, CYCLIC H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (DISULFIDE BRIDGE: 3-14)