HEXAMETHONIUM BROMIDE
- CAS No.
- 55-97-0
- Chemical Name:
- HEXAMETHONIUM BROMIDE
- Synonyms
- hexameton;vegolysen;vegolysin;esametina;gangliostat;Methobromine;simpatoblock;hexoniumdibromide;hexamethioniumbromide;HEXAMETHONIUM BROMIDE
- CBNumber:
- CB6429850
- Molecular Formula:
- C12H30Br2N2
- Molecular Weight:
- 362.19
- MDL Number:
- MFCD00011787
- MOL File:
- 55-97-0.mol
- MSDS File:
- SDS
| Melting point | ~285 °C (dec.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Water (Slightly) |
| form | Crystalline Powder and Agglomerates |
| color | White |
| PH | pH (20g/l, 25℃) : 4.5～6.5 |
| Merck | 14,4688 |
| BRN | 3715749 |
| InChIKey | FAPSXSAPXXJTOU-UHFFFAOYSA-L |
| CAS DataBase Reference | 55-97-0(CAS DataBase Reference) |
| FDA UNII | 8J77X3S603 |
| EPA Substance Registry System | 1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2) (55-97-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H370 | |||||||||
| Precautionary statements | P501-P260-P270-P264-P308+P311-P405 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | BQ8575000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29239000 | |||||||||
| NFPA 704 |
|
HEXAMETHONIUM BROMIDE price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H0879 | Hexamethonium bromide | 55-97-0 | 5g | $27 | 2024-03-01 | Buy |
| Sigma-Aldrich | H0879 | Hexamethonium bromide | 55-97-0 | 25g | $92.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.05313 | Hexamethonium Bromide - CAS 55-97-0 - Calbiochem | 55-97-0 | 5G | $80.7 | 2023-01-07 | Buy |
| TCI Chemical | H0481 | Hexamethonium Bromide >98.0%(N)(T) | 55-97-0 | 25g | $61 | 2024-03-01 | Buy |
| TCI Chemical | H0481 | Hexamethonium Bromide >98.0%(N)(T) | 55-97-0 | 500g | $583 | 2024-03-01 | Buy |
HEXAMETHONIUM BROMIDE Chemical Properties,Uses,Production
Description
Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs). It decreases acetylcholine release induced by carbamoylcholine in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 μg/ml. It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg. Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats. Formulations containing hexamethonium were previously used in the treatment of hypertension.
Chemical Properties
White crystalline powder and agglomerates
Originator
Bistrium,Squibb,US,1951
Uses
Hexamethonium bromide has been used:
- as an autonomic ganglia-blocking agent to study its effects on whisker movement in rats
- as a nicotinic receptor antagonist to study its effects on antigen-induced arthritis (AIA) progression in mice
- as a non-selective ganglionic nicotinic acetylcholine receptor (nAChR) antagonist to study its effects on cytisine-induced autonomic cardiovascular responses in mice
Manufacturing Process
Hexamethylene diamine (116 g), sodium carbonate (466 g), and water (800
ml) were heated to 60°C, and dimethyl sulfate (830 g) added with stirring
over 1% hours keeping the temperature below 90°C. The reaction mixture
was then stirred at 90°C for 2 hours, then cooled to 20°C, acetone (1,200 ml)
added and the whole cooled to 0°C.
The solid formed was removed by filtration and washed with acetone (150
ml). Filtrate and washings were diluted with water to 4 liters and heated to
60°C under reflux. To this was added a solution prepared from embonic acid
(388 g), sodium hydroxide (80 g) and water (5 liters), the whole refluxed for
10 minutes and thereafter allowed to cool overnight.
The resultant embonate (530 g) was filtered off, washed twice with a solution
of acetone (75 ml) in water (425 ml), and dried at 100°C to give an
amorphous yellow powder, MP 290°C to 291°C (with decomp.). 588 g of the
embonate was dissolved in boiling water (4 liters).
Hydrobromic acid 50% w/w (325 g) diluted with water (2 liters) was added
slowly at the boil and the precipitated embonic acid removed by filtering hot
and washing twice with hot water (1 liter). The filtrate and washings were
evaporated to dryness in a steam pan and the residue recrystallized from
ethyl alcohol (1,200 ml), to yield the dibromide (320 g).
Therapeutic Function
Antihypertensive
Biochem/physiol Actions
Hexamethonium bromide is a nicotinic acetylcholine receptor (nAChR) antagonist. It preferentially blocks nicotinic receptors at autonomic ganglia. It can cross the blood-brain barrier only at high doses.
HEXAMETHONIUM BROMIDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 6710 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 |
View Lastest Price from HEXAMETHONIUM BROMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-01-16 | HEXAMETHONIUM BROMIDE
55-97-0
|
US $20.00 / kg | 1kg | 99% | 5000 tons | Hebei Duling International Trade Co. LTD | |
 |
2021-08-11 | HEXAMETHONIUM BROMIDE USP/EP/BP
55-97-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-06-02 | Hexamethonium bromide
55-97-0
|
US $6.00 / kg | 1kg | High quality Professional Factory | Ms Ella chemwill_asia@126.com www.chemwill.com | Chemwill Asia Co.,Ltd. |
-
- HEXAMETHONIUM BROMIDE
55-97-0
- US $20.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- HEXAMETHONIUM BROMIDE USP/EP/BP
55-97-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Hexamethonium bromide
55-97-0
- US $6.00 / kg
- High quality Professional Factory
- Chemwill Asia Co.,Ltd.
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