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4-Pyrazoleboronic acid pinacol ester

4-Pyrazoleboronic acid pinacol ester Structure
4-Pyrazoleboronic acid pinacol ester structure
CAS No.
269410-08-4
Chemical Name:
4-Pyrazoleboronic acid pinacol ester
Synonyms
4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;PYRAZOLE-4-BORONIC ACID PINACOL ESTER;4-Pyrazoleboronic acid pinaol ester;4,4,5,5-TETRAMETHYL-2-(1H-PYRAZOL-4-YL)-1,3,2-DIOXABOROLANE;Baricitinib-005;Triazolam Impurity 6;eboronic acid pinacoL;Crizotinib Intermediates 4;Pinacol Pyrazol-4-ylboronate;4-PYRAZOLEBORONIC ACID PINACOL ESTER
CBNumber:
CB6449821
Molecular Formula:
C9H15BN2O2
Molecular Weight:
194.04
MDL Number:
MFCD03453063
MOL File:
269410-08-4.mol
MSDS File:
SDS
Last updated:2024-04-08 16:27:35
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4-Pyrazoleboronic acid pinacol ester Properties

Melting point 142-146 °C (lit.)
Boiling point 335.4±15.0 °C(Predicted)
Density 1.09±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO, Ethyl Acetate, Methanol
pka 13.36±0.50(Predicted)
form Powder
color Off-white to tan
Water Solubility insoluble
InChIKey TVOJIBGZFYMWDT-UHFFFAOYSA-N
CAS DataBase Reference 269410-08-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi,F
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
Hazard Note  Irritant/Flammable
TSCA  No
HS Code  29331990
NFPA 704
1
2 0

4-Pyrazoleboronic acid pinacol ester price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 525057 4-Pyrazoleboronic acid pinacol ester 97% 269410-08-4 1g $21.16 2024-03-01 Buy
Sigma-Aldrich 525057 4-Pyrazoleboronic acid pinacol ester 97% 269410-08-4 5g $76.5 2024-03-01 Buy
TCI Chemical T2756 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole >97.0%(GC) 269410-08-4 1g $42 2024-03-01 Buy
TCI Chemical T2756 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole >97.0%(GC) 269410-08-4 5g $140 2024-03-01 Buy
Alfa Aesar L19654 1H-Pyrazole-4-boronic acid pinacol ester, 98% 269410-08-4 1g $68.65 2024-03-01 Buy
Product number Packaging Price Buy
525057 1g $21.16 Buy
525057 5g $76.5 Buy
T2756 1g $42 Buy
T2756 5g $140 Buy
L19654 1g $68.65 Buy

4-Pyrazoleboronic acid pinacol ester Chemical Properties,Uses,Production

Chemical Properties

Off-white to tan powder

Uses

Reagent used for

  • Suzuki-Miyaura cross-couplings
  • Ruthenium-catalyzed asymmetric hydrogenation

Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including
  • VEGF
  • Aurora
  • Rho (ROCK)
  • Janus Kinase 2 (JAK)
  • c-MET
  • ALK
  • S-nitrosoglutathione reductase
  • CDC7
  • Acetyl-CoA carboxylase
  • Prosurvival Bcl-2 protein
  • Viral RNA-Dependent RNA polymerase
  • Long Chain Fatty Acid Elongase 6
  • PI3
  • AKT
  • Chk1
  • Protein Kinase B

Uses

1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.

Uses

4-Pyrazoleboronic Acid Pinacol Ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.

4-Pyrazoleboronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

1-{2-[(Tetrahydro-2H-pyran-2-yl)oxy]ethyl}-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Boc-pyrazole-4-boronic acid pinacol ester 1-(2,2-difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-([2-(trimethylsilyl)ethoxy]methyl)-1H-pyrazole 1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 4-hydroxypyrazole 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester
2-(methylthio)-4-(1H-pyrazol-4-yl)pyrimidine tert-butyl (2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)carbamate

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4-Pyrazoleboronic acid pinacol ester Suppliers

Global( 439)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Million Pharmaceutical Co., Ltd 		+86-531-68659554 +8613031714605 info@millionpharm.com China 153 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7786 58
Springchem New Material Technology Co.,Limited 		+86-021-62885108 +8613917661608 info@spring-chem.com China 2068 57
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 906 58
Supplier Advantage
Jinan Million Pharmaceutical Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Springchem New Material Technology Co.,Limited 		57
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shanghai Arbor Chemical Co., Ltd. 		58

View Lastest Price from 4-Pyrazoleboronic acid pinacol ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Pyrazoleboronic acid pinacol ester pictures 2024-04-25 4-Pyrazoleboronic acid pinacol ester
269410-08-4
 US $2.00 / kg 1kg 99% 1200KG/M Jinan Million Pharmaceutical Co., Ltd
4-Pyrazoleboronic acid pinacol ester pictures 2024-04-08 4-Pyrazoleboronic acid pinacol ester
269410-08-4
 US $34.00-1.20 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
4-Pyrazoleboronic acid pinacol ester pictures 2023-09-13 4-Pyrazoleboronic acid pinacol ester
269410-08-4
 US $0.00 / kg 1kg 99.50% 20tons Hebei Yanxi Chemical Co., Ltd.

4-Pyrazoleboronic acid pinacol ester Spectrum

4-Pyrazoleboronic acid pinacol ester(269410-08-4)1HNMR4-Pyrazoleboronic acid pinacol ester(269410-08-4)IR

269410-08-4(4-Pyrazoleboronic acid pinacol ester)Related Search:

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Zolpidem tartrate PROPARGYL BENZOATE 98 Propyl 4-bromo-3-methylbenzoate Propyl 3-bromo-2-chloroisonicotinate 4,4,5,5-Tetramethyl-2-(prop-1-enyl)-1,3,2-dioxaborolane
Pyrazolo[1,5-a]pyridine-3-carbonitrile PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIAMINE Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI) 4-Pyridineboronic acid pinacol ester Pyridine, 2-chloro-5-(5-methyl-1H-pyrazol-3-yl)-
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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole,min.97% 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, min. 97% 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole4-Pyrazoleboronic acid pinacol ester 4-Pyrazoleboronic acid pinacol ester,97% 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole 1H-Pyrazole, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+% 1GR 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+% 5GR (1H-Pyrazol-4-yl)boronic acid pinacol ester 4-Pyrazoleboronic acid pinacol ester, >=98% 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 1H-pyrazol-4-ylboronate Pinacol Pyrazol-4-ylboronate 2-(1H-Pyrazol-4-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane 4,4,5,5-TetraMethyl-2-(1H-pyrazol-2-yl)-1,3,2-dioxaborolane Pyrazol-4-ylboronic Acid Pinacol Ester 1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER 4-PYRAZOLEBORONIC ACID PINACOL ESTER 2-(4-Pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-Pyrazoleboronic Acid Pinacol Ester 2-(1H-Pyrazole-4-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+% 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1H-Pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-Pyrazoleboronic acid pinacol ester 97% 4-pyrazolyl boronic acid pinacol ester 4,4,5,5-Tetramethyl-2-(pyrazol-4-yl)-1,3,2-dioxaborolane Pyrazole-4-boronic acid sorbitol ester 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole4-Pyrazoleboronic ac 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97%, for synthesis eboronic acid pinacoL Baricitinib-005 2-(4-Pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORLAN-2-YL)-1H-PYRAZOLE 4-Pyrazoleboronic acid pinaol ester PYRAZOLE-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 4,4,5,5-TETRAMETHYL-2-(1H-PYRAZOL-4-YL)-1,3,2-DIOXABOROLANE Crizotinib Intermediates 4 Triazolam Impurity 6 269410-08-4 CH34C2O2BC3N2H3 C9H15BN2O2 Heteroaryl Organometallic Reagents Boronic Acids and Derivatives Boronate Esters organic or inorganic borate Pyrazole series API intermediates Boronic acid OLED materials,pharm chemical,electronic 269410-08-4