ChemicalBook >> CAS DataBase List >>GGTI-298

GGTI-298

CAS No.
180977-44-0
Chemical Name:
GGTI-298
Synonyms
CS-2228;GGTI-298;GGTI298 (GGTI-298;GGTI-298 free base;GGTI298 (CF3CO2H)salt;GGTI-298 trifluoroacetate salt;N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-NAPHTHYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA;L-Leucine, N-[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester;N-[[4-(2-(R)-AMINO-3-MERCAPTOPROPYL)AMINO]-2-NAPHTHYLBENZOYL]LEUCINE METHYL ESTER TRIFLUOROACETATE SALT;N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucinemethylestertrifluoroacetatesalt
CBNumber:
CB6450528
Molecular Formula:
C27H33N3O3S
Molecular Weight:
479.63
MDL Number:
MFCD06409252
MOL File:
Mol file
Last updated:2023-07-12 17:07:59

GGTI-298 Properties

Melting point 99.5-100 °C
Boiling point 673.7±55.0 °C(Predicted)
Density 1.190±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility DMSO: 22 mg/mL
form solid
pka 9.83±0.10(Predicted)
color off-white
FDA UNII ELA97V8Q7P

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3

GGTI-298 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 2430 GGTI298 ≥95%(HPLC) 180977-44-0 1 $212 2021-12-16 Buy
Usbiological 255374 GGTI 298 180977-44-0 1mg $460 2021-12-16 Buy
Biorbyt Ltd orb611699 GGTI298 180977-44-0 5mg $555.9 2021-12-16 Buy
American Custom Chemicals Corporation INB0001112 GGTI-298 95.00% 180977-44-0 0.25MG $599.45 2021-12-16 Buy
Biorbyt Ltd orb611699 GGTI298 180977-44-0 1mg $306 2021-12-16 Buy
Product number Packaging Price Buy
2430 1 $212 Buy
255374 1mg $460 Buy
orb611699 5mg $555.9 Buy
INB0001112 0.25MG $599.45 Buy
orb611699 1mg $306 Buy

GGTI-298 Chemical Properties,Uses,Production

Uses

GGTI 298 is a CAAX peptidomimetic that selectively inhibits geranylgeranyltransferase I (GGTase I). It has been shown to arrest human tumor cells and induce apoptosis.

Definition

ChEBI: (2S)-2-[[[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)phenyl]-oxomethyl]amino]-4-methylpentanoic acid methyl ester is a leucine derivative.

GGTI-298 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 71)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co
+86-0371-86658258 15093356674; laboratory@coreychem.com China 30256 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 50001 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
GGTI-298 N-[[4-(2-(R)-AMINO-3-MERCAPTOPROPYL)AMINO]-2-NAPHTHYLBENZOYL]LEUCINE METHYL ESTER TRIFLUOROACETATE SALT N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-NAPHTHYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA GGTI-298 trifluoroacetate salt N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucinemethylestertrifluoroacetatesalt GGTI298 (CF3CO2H)salt CS-2228 GGTI298 (GGTI-298 methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-naphthalen-1-ylbenzoyl]amino]-4-methylpentanoate,2,2,2-trifluoroacetic acid L-Leucine, N-[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester GGTI-298 free base 180977-44-0 C27H33N3O3SC2HF3O2 C27H33N3O3SCF3CO2H A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297.