SULFISOMIDINE | 515-64-0

SULFISOMIDINE Properties

Melting point	245°C
Boiling point	294°C (rough estimate)
Density	1.2997 (rough estimate)
refractive index	1.6440 (estimate)
storage temp.	0-6°C
solubility	Acetonitrile (Slightly), DMSO (Slightly)
pka	pKa 7.25 (Uncertain)
color	White to Off-White
Water Solubility	1.382g/L(25 ºC)
Merck	8951
BRN	261305
FDA UNII	W03L3ODK6E
ATC code	J01EB01

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	22-24/25-36-26
RIDADR	3249
WGK Germany	2
RTECS	WO9270000
HazardClass	6.1(b)
PackingGroup	III

SULFISOMIDINE price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	46908	Sulfisomidin VETRANAL?, analytical standard	515-64-0	250mg	$53.6	2022-05-15	Buy
TRC	S699378	Sulfisomidine	515-64-0	25mg	$45	2021-12-16	Buy
Biosynth Carbosynth	FA131378	4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide	515-64-0	500mg	$50	2021-12-16	Buy
Matrix Scientific	136051	4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide 95%+	515-64-0	5g	$323	2021-12-16	Buy
American Custom Chemicals Corporation	API0007837	SULFISOMIDINE 95.00%	515-64-0	10MG	$400.3	2021-12-16	Buy

Product number	Packaging	Price	Buy
46908	250mg	$53.6	Buy
S699378	25mg	$45	Buy
FA131378	500mg	$50	Buy
136051	5g	$323	Buy
API0007837	10MG	$400.3	Buy

SULFISOMIDINE Chemical Properties,Uses,Production

Originator

Elkosin,Ciba,US,1951

Uses

Sulfisomidine is a sulfanilamide antibacterial agent.

Definition

ChEBI: A sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.

Manufacturing Process

This starting material can be prepared as follows. 123 parts of finely powdered 6-amino-2,4-dimethylpyrimidine are suspended in 250 parts of dry pyridine and 222 parts of p-nitrobenzenesulfonyl chloride added at 50°C to 55°C. The whole is then warmed for 2 hours to 55°C. Water is added to the crystalline aggregate obtained, the precipitated bis-N-(pnitrobenzenesulfonyl)- 6-amino-2,4-dimethylpyrimidine filtered off by suction and washed with water. It is purified by recrystallizing from methyl ethyl ketone. On slowly heating it decomposes; on rapidly heating it melts at about 210°C to 215°C with decomposition.
49.3 parts of bis-N-(p-nitrobenzenesulfonyl)-6-amino-2,4-dimethylpyrimidine are heated to boiling for one hour with 12.3 parts of 6-amino-2,4- dimethylpyrimidine in 50 parts of dry pyridine. After cooling, the 6-(pnitrobenzenesulfonamido)- 2,4-dimethylpyrimidine formed is precipitated with water and filtered off by suction. It is purified by dissolving in dilute caustic soda and precipitating with acid. On recrystallization from dilute alcohol it melts (with decomposition) at 188°C to 189°C.
On reaction, for example, with iron and hydrochloric acid, 6-(paminobenzenesulfonamido)- 2,4-dimethylpyrimidine, melting point 236°C is obtained.

brand name

Isosulf;Oestro-gynedron;Poly-gynedron;Sulfamethine;Tricho-gynedron.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Sulfisomide, a sulfonamide anti-infective agent, was introduced several decades ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfisomide is still used topically in some countries for vaginal infection.

Pharmaceutical Applications

6-Sulfanilamido-2,4-dimethylpyrimidine (syn: sulphasomidine). A highly soluble sulfonamide with a plasma half-life of 6–8 h. Protein binding is about 90%. Activity is similar to that of sulfadiazine. It is less extensively metabolized than most other sulfonamides and is largely excreted unchanged in the urine.

SULFISOMIDINE synthesis

Synthesis of SULFISOMIDINE from N-Acetylsulfanilyl chloride

SULFISOMIDINE Preparation Products And Raw materials

Raw materials

Hydrochloric acid 4-Nitrobenzenesulfonyl chloride

Preparation Products

SULFISOMIDINE Suppliers

Global( 134)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81148696 +8615536356810	1047@dideu.com	China	3459	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
WinWin Chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	13854	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9116	58

Supplier	Advantage
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
WinWin Chemical CO., Limited	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Alfa Chemistry	58
Shaanxi Didu New Materials Co. Ltd	58

View Lastest Price from SULFISOMIDINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-14	SULFISOMIDINE USP/EP/BP 515-64-0	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2020-05-03	SULFISOMIDINE 515-64-0	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	SULFISOMIDINE 515-64-0	US $1.00 / KG	1G	98%	100KG	Career Henan Chemical Co

SULFISOMIDINE USP/EP/BP
515-64-0
US $1.10 / g
99.9%
Dideu Industries Group Limited

SULFISOMIDINE
515-64-0
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

SULFISOMIDINE
515-64-0
US $1.00 / KG
98%
Career Henan Chemical Co

SULFISOMIDINE Spectrum

SULFISOMIDINE(515-64-0)MS SULFISOMIDINE(515-64-0)¹HNMR SULFISOMIDINE(515-64-0)¹³CNMR SULFISOMIDINE(515-64-0)IR1 SULFISOMIDINE(515-64-0)IR2

515-64-0(SULFISOMIDINE)Related Search:

SULFISOMIDINE Sulfaclomid Sulfanilamide 4-AMINO-2,6-DIMETHYLPYRIMIDINE SULFISOMIDINE, SODIUM

AURORA 8501 AURORA 10892 AURORA 7814 AURORA 22997 N-(4-(((2,6-DIMETHYLPYRIMIDIN-4-YL)AMINO)SULFONYL)PHENYL)-2-THIENYLFORMAMIDE

2-ACETYL-3-((4-(((2,6-DIMETHYLPYRIMIDIN-4-YL)AMINO)SULFONYL)PHENYL)AMINO)-N-PHENYLPROP-2-ENAMIDE 2-(((4-(((2,6-DIMETHYLPYRIMIDIN-4-YL)AMINO)SULFONYL)PHENYL)AMINO)METHYLENE)INDANE-1,3-DIONE AURORA 9455 AURORA 22995 AURORA 11359

AURORA 7318 AURORA 1185 AURORA 10804

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(p-aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin (p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidine 2,4-Dimethyl-6-sulfanilamidopyrimidine 2,6-Dimethyl-4-sulfanilamidopyrimidine 4-amino-n-(2,6-dimethyl-4-pyrimidinyl)-benzenesulfonamid 4-Sulfa-2,6-dimethylpyrimidine 4-Sulfanilamido-2,6-dimethylpyrimidine 6-(4-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine 6-(p-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine 6-(p-Aminobenzenesulfonyl)amino-2,4-dimethylpyrimidine 6-(p-aminophenylsulfonamido)-2,4-dimethylpyrimidine 6-[(p-aminobenzenesulfonyl)amino]-2,4-dimethylpyrimidine 6-Sulfanilamido-2,4-dimethylpyrimidine Aristamid Aristamide Aristogyn Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)- benzenesulfonamide,4-amino-N-(2,6-dimethyl-4-pyrimidinyl)- Domian Elcosin N1-(2,6-DIMETHYLPYRIMIDIN-4-YL)SULFANILAMIDE SULFISOMIDINE Elcosine Elkosil Elkosin Elkosine erycon Mefenal n(sup1)-(2,6-dimethyl-4-pyrimidinyl)-sulfanilamid n(sup1)-(2,6-dimethyl-4-pyrimidinyl)sulfanilamide N¹-(2,6-Dimethyl-4-pyrimidinyl)sulfanilamide N1-(2,6-dimethyl-4-pyrimidinyl)sulfanilamide Sulfadimetine Sulfaisodimerazine Sulfamethin 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide, N1-(2,6-Dimethylpyrimidin-4-yl)sulfanilamide 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide 4-azanyl-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide SULFISOMIDIN VETRANAL Sulfisomidine solution,100ppm (p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin [German] 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide (9CI) 6-(p-Aminobenzenesulfo Sulfisomidine (JAN) Sulfisomidine (TN) Sulfanilamide, N¹-(2,6-dimethyl-4-pyrimidinyl)- sulfanilamide,N1-(2,6-dimethyl-4-pyrimidinyl)- Sulfasomidine Sulphasomidine AKOS BBS-00004571 4-AMINO-N-(2,6-DIMETHYL-4-PYRIMIDINYL)BENZENESULFONAMIDE N1-(2,6-dimethylpyrimidin-4-yl)sulphanilamide SULPHISOMIDINE SULFISOMIDINE STANDARD Sulfisomidine > Sulfisomidine Solution in Methanol, 1000μg/mL SULFISOMIDINE USP/EP/BP SULFISOMIDIN