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2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide structure
CAS No.
108605-62-5
Chemical Name:
2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
Synonyms
Su 20;CS-862;Aubagio;A77 1726;Aids013145;Aids-013145;rac-A77 1626;Teriflunomide;TeriflunoMide, A77 1726;Teriflunomide((E/Z) Mixture)
CBNumber:
CB6464433
Molecular Formula:
C12H9F3N2O2
Formula Weight:
270.21
MOL File:
108605-62-5.mol

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Properties

Boiling point:
410.8±45.0 °C(Predicted)
Density 
1.424±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
5.20±0.50(Predicted)
form 
neat
FDA UNII
1C058IKG3B
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Hazard Codes  Xn
Risk Statements  22
HS Code  2926900005

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0936 Teriflunomide ≥98% (HPLC) 108605-62-5 10 mg $61.6 2021-03-22 Buy
Sigma-Aldrich SML0936 Teriflunomide ≥98% (HPLC) 108605-62-5 50 mg $262 2021-03-22 Buy
Sigma-Aldrich 1357056 Leflunomide Related Compound B United States Pharmacopeia (USP) Reference Standard 108605-62-5 20mg $1160 2020-08-18 Buy

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Chemical Properties,Uses,Production

Description

Teriflunomide (Aubagio®), also known as A77 1726, is an immunosupressant marketed by Sanofi for the teatment of multiple sclerosis (MS). Teriflunomide is the active metabolite of leflunomide, used for treatment of patients diagnosed with rheumatoid arthritis, and therefore simultaneously can be used as a treatment for rheumatoid arthritis.Teriflunomide acts as an inhibitor of the mitochondrial enzyme dihydrorotate dehydrogenase, inhibiting pyrimidine formation, and resulting in reduced B and T cell proliferation.

Chemical Properties

White Solid

Uses

The active metabolite of Leflunomide, 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide can be used as a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis.

Chemical Synthesis

Numerous syntheses of teriflunomide have been developed to date, most relying on the use of 4- trifluoromethyl aniline (167). The current optimized method for scale-up synthesis of teriflunomide, developed by Keshav and coworkers, begins with reaction of commercial 4-trifluoromethyl aniline 167 and ethylacetoacetate (168) in refluxing xylenes, providing acetoamidate 169 in 51% yield . The resulting acetoamidate 169 was then treated with H2O2, KBr, and concentrated HCl at room temperature, providing bromide 170 in 67% yield. Bromide 170 was reacted with NaCN in DMSO, generating teriflunomide (XXVI) in 85% yield.

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Preparation Products And Raw materials

Raw materials

Preparation Products


2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Suppliers

Global( 118)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
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ATK CHEMICAL COMPANY LIMITED
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+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
career henan chemical co
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Hubei Jusheng Technology Co.,Ltd.
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027-59599243 linda@hubeijusheng.com CHINA 28229 58
Chongqing Chemdad Co., Ltd
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sales@chemdad.com CHINA 37282 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58

View Lastest Price from 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 TeriflunoMide, A77 1726
108605-62-5
US $0.00-0.00 / KG 5mg 99% HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
2019-07-06 A77 1726
108605-62-5
US $1.00 / KG 1G 99% 100KG career henan chemical co

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