Iodixanol
- CAS No.
- 92339-11-2
- Chemical Name:
- Iodixanol
- Synonyms
- OptiPrep;Visipaque;DU-6807;Ioxanol;Ioxaxol;Acupaque;odixanol;lodoanol;2-5410-3A;IODIXANOL
- CBNumber:
- CB6465056
- Molecular Formula:
- C35H44I6N6O15
- Molecular Weight:
- 1550.18
- MDL Number:
- MFCD00867965
- MOL File:
- 92339-11-2.mol
| Melting point | 262-267°C (dec.) |
|---|---|
| Boiling point | 1250.9±65.0 °C(Predicted) |
| Density | 1.266 ±0.003 |
| vapor pressure | 0Pa at 20℃ |
| refractive index | n 1.4128 ±0.0003 |
| storage temp. | Refrigerator |
| solubility | Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride. |
| pka | 11.04±0.46(Predicted) |
| color | White |
| LogP | 0.7 |
| FDA UNII | HW8W27HTXX |
| NCI Drug Dictionary | iodixanol |
| ATC code | V08AB09 |
| EPA Substance Registry System | 1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- (92339-11-2) |
Iodixanol price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001294 | Iodixanol European Pharmacopoeia (EP) Reference Standard | 92339-11-2 | y0001294 | $220 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR3015 | Iodixanol pharmaceutical secondary standard, certified reference material | 92339-11-2 | 500MG | $230 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1343517 | Iodixanol | 92339-11-2 | 200mg | $436 | 2024-03-01 | Buy |
| TRC | I667200 | Iodixanol | 92339-11-2 | 100mg | $1165 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007294 | IODIXANOL (60% SOLUTION IN WATER) 95.00% | 92339-11-2 | 1G | $12400 | 2021-12-16 | Buy |
Iodixanol Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
OptiPrep,Nycomed Pharma,Norway
Uses
Nonionic, dimeric x-ray contrast medium. Diagnostic aid (radiopaque medium).
Definition
ChEBI: A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.
Manufacturing Process
Dimethyl 5-nitroisophthalate (215 g) and 1-amino-2,3-propandiol (196 g)were refluxed in methanol (500 ml). After twenty hours the solution was
cooled and stored in a refrigerator overnight. The product 5-nitro-N,N'-
bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with
methanol. Yield: 270 g (84%). M.p. 128-132°C.
5-Nitro-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (18.1 g) was suspended
in water (250 ml), conc. hydrochloric acid (4.2 ml) and 10% PdO/charcoal
(0.5 g) were added, and the mixture hydrogenated in a Parr apparatus for one
day. After filtration the filtrate was heated at 80-90°C and 3.88 M NaICl2
(42.5 ml) was added through a dropping funnel over 1 hour. The solution was
heated for 2.5 hours. After cooling to 20°C 5-amino-2,4,6-triiodo-N,N'-
bis(2,3-dihydroxypropyl)-isophthalamide crystallized out.
5-Amino-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (110 g)
was suspended in acetic anhydride (480 ml) and heated to 50°C.
Concentrated sulfuric acid (3 ml) was then added. The starting material was
dissolved after a few minutes, and the reaction mixture was heated at 60°C
for 75 min. After cooling the residue dissolved in methanol (300 ml) with
water (150 ml) the solution was heated to 50°C and the pH adjusted to about
10.5 by 10 N sodium hydroxide. After 4-5 hours the pH didn't decrease, and
the hydrolysis was complete. The reaction mixture was cooled to 20°C and
neutralized by adding hydrochloric acid. After stirring overnight 5-Acetamido-
2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide was filtered and
washed with water. Yield: 94 g (80%). Melting point 275°C, dec.
2-Methoxyethanol (300 ml) and sodium hydroxide (20 g) was added to the
reactor at 50°C, and 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-
triiodoisophtalamide (304 g) was added after two hours of stirring. All solids
were allowed to dissolve overnight before cooling to 30°C and adjustment to
pH 12 with diluted hydrochloric acid. Epichlorohydrin (11 g) was added to the
solution after further cooling to 15°C, and the reaction was allowed to proceed
for 51 hours. As a result 1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3-
dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane was
obtained.
brand name
Visipaque (GE Healthcare).
Therapeutic Function
Diagnostic aid
General Description
Iodixanol is a viscous, isosmolar,nonionic, water-soluble dimer with 49% iodine content.It is formulated as an isotonic solution for intravascular injectionand indicated for excretory urography, angiography,and CT procedures.
Iodixanol Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Yutian pharmaceutical Co.,Ltd. | +undefined-0518-86098006 +undefined19851887368 | lvan.hui@jsytsw.com | China | 80 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from Iodixanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-29 | Iodixanol
92339-11-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-08-18 | Iodixanol
92339-11-2
|
US $0.00-0.00 / g | 1g | 0.99 | 100kg | Weifang Wehibest Supply Chain Co.,Ltd | |
 |
2023-08-16 | Iodixanol
92339-11-2
|
US $30.00 / KG | 1KG | >99% | 20tons | Weijer International Trade (Hebei) Co., Ltd |
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