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Iodixanol

Iodixanol
Iodixanol structure
CAS No.
92339-11-2
Chemical Name:
Iodixanol
Synonyms
DU-6807;odixanol;Acupaque;OptiPrep;lodoanol;IODIXANOL;2-5410-3A;Visipaque;iodexanol;Iodixanol CRS
CBNumber:
CB6465056
Molecular Formula:
C35H44I6N6O15
Formula Weight:
1550.18
MOL File:
92339-11-2.mol

Iodixanol Properties

Melting point:
262-267°C (dec.)
Boiling point:
1250.9±65.0 °C(Predicted)
Density 
1.266 ±0.003
refractive index 
n 1.4128 ±0.0003
storage temp. 
Refrigerator
solubility 
Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.
form 
neat
pka
11.04±0.46(Predicted)
FDA UNII
HW8W27HTXX
NCI Drug Dictionary
iodixanol
ATC code
V08AB09
EPA Substance Registry System
1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- (92339-11-2)
SAFETY
  • Risk and Safety Statements
HS Code  2924296000
Toxicity LD50 i.v. in mice: 21 gI/kg (Palmers)

Iodixanol price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001294 Iodixanol European Pharmacopoeia (EP) Reference Standard 92339-11-2 y0001294 $190 2020-08-18 Buy
Sigma-Aldrich Y0001294 Iodixanol European Pharmacopoeia (EP) Reference Standard 92339-11-2 $190 2021-03-22 Buy
Sigma-Aldrich 1343517 Iodixanol 92339-11-2 200mg $366 2021-03-22 Buy

Iodixanol Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

OptiPrep,Nycomed Pharma,Norway

Uses

Nonionic, dimeric x-ray contrast medium. Diagnostic aid (radiopaque medium).

Definition

ChEBI: A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.

Manufacturing Process

Dimethyl 5-nitroisophthalate (215 g) and 1-amino-2,3-propandiol (196 g)were refluxed in methanol (500 ml). After twenty hours the solution was cooled and stored in a refrigerator overnight. The product 5-nitro-N,N'- bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with methanol. Yield: 270 g (84%). M.p. 128-132°C.
5-Nitro-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (18.1 g) was suspended in water (250 ml), conc. hydrochloric acid (4.2 ml) and 10% PdO/charcoal (0.5 g) were added, and the mixture hydrogenated in a Parr apparatus for one day. After filtration the filtrate was heated at 80-90°C and 3.88 M NaICl2 (42.5 ml) was added through a dropping funnel over 1 hour. The solution was heated for 2.5 hours. After cooling to 20°C 5-amino-2,4,6-triiodo-N,N'- bis(2,3-dihydroxypropyl)-isophthalamide crystallized out.
5-Amino-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (110 g) was suspended in acetic anhydride (480 ml) and heated to 50°C. Concentrated sulfuric acid (3 ml) was then added. The starting material was dissolved after a few minutes, and the reaction mixture was heated at 60°C for 75 min. After cooling the residue dissolved in methanol (300 ml) with water (150 ml) the solution was heated to 50°C and the pH adjusted to about 10.5 by 10 N sodium hydroxide. After 4-5 hours the pH didn't decrease, and the hydrolysis was complete. The reaction mixture was cooled to 20°C and neutralized by adding hydrochloric acid. After stirring overnight 5-Acetamido- 2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with water. Yield: 94 g (80%). Melting point 275°C, dec.
2-Methoxyethanol (300 ml) and sodium hydroxide (20 g) was added to the reactor at 50°C, and 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophtalamide (304 g) was added after two hours of stirring. All solids were allowed to dissolve overnight before cooling to 30°C and adjustment to pH 12 with diluted hydrochloric acid. Epichlorohydrin (11 g) was added to the solution after further cooling to 15°C, and the reaction was allowed to proceed for 51 hours. As a result 1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3- dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane was obtained.

brand name

Visipaque (GE Healthcare).

Therapeutic Function

Diagnostic aid

General Description

Iodixanol is a viscous, isosmolar,nonionic, water-soluble dimer with 49% iodine content.It is formulated as an isotonic solution for intravascular injectionand indicated for excretory urography, angiography,and CT procedures.

Iodixanol Preparation Products And Raw materials

Raw materials

Preparation Products


Iodixanol Suppliers

Global( 168)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from Iodixanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Iodixanol
92339-11-2
US $100.70 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-11-15 Iodixanol
92339-11-2
US $0.50 / g 1KG 99% 500ton/Month Hebei Yirun Sega Biological Technology Co. Ltd
2021-10-20 Iodixanol
92339-11-2
US $350.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

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