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4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one structure

CAS No.: 28664-35-9

Chemical Name:: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one

Synonyms: SOTOLON;3-hydroxy-4,5-dimethylfuran-2(5H)-one;3-HYDROXY-4,5-DIMETHYL-2(5H)-FURANONE;SOTOLONE;SUGAR LACTONE;CARAMEL FURANONE;FENUGREEK LACTONE;3-hydroxy-4,5-dimethyl-2(5H)-furanone (sotolon);FEMA 3634;3-hydroxy-4,5-dimethyl-2(5h)-furanon

CBNumber:: CB6466523

Molecular Formula:: C6H8O3

Molecular Weight:: 128.13

MDL Number:: MFCD00059957

MOL File:: 28664-35-9.mol

MSDS File:: SDS

Last updated:2024-03-26 17:16:27

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4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Properties

Melting point	26-29 °C(lit.)
Boiling point	184 °C(lit.)
Density	1.049 g/mL at 25 °C
refractive index	n20/D 1.491(lit.)
FEMA	3634 \| 4,5-DIMETHYL-3-HYDROXY-2,5-DIHYDROFURAN-2-ONE
Flash point	>230 °F
storage temp.	Sealed in dry,2-8°C
pka	9.28±0.40(Predicted)
Odor	at 0.01 % in propylene glycol. extremely sweet strong caramel maple burnt sugar coffee
Odor Type	caramellic
JECFA Number	243
InChIKey	UNYNVICDCJHOPO-UHFFFAOYSA-N
LogP	-0.44
CAS DataBase Reference	28664-35-9(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	4,5-DIMETHYL-3-HYDROXY-2,5-DIHYDROFURAN-2-ONE
EWG's Food Scores	1
FDA UNII	T62RL2NEGW
NIST Chemistry Reference	2(5H)-furanone, 3-hydroxy-4,5-dimethyl-(28664-35-9)
EPA Substance Registry System	2(5H)-Furanone, 3-hydroxy-4,5-dimethyl- (28664-35-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Risk Statements

20/22

Safety Statements

WGK Germany

HS Code

29329990

NFPA 704

	1
0		0

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W363499	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one natural, ≥97%, FG	28664-35-9	SAMPLE-K	$220	2024-03-01	Buy
Sigma-Aldrich	W363499	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one natural, ≥97%, FG	28664-35-9	25G	$292	2024-03-01	Buy
Sigma-Aldrich	W363499	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one natural, ≥97%, FG	28664-35-9	100G	$819	2024-03-01	Buy
Sigma-Aldrich	W363421	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one solution 3?wt. % in propylene glycol	28664-35-9	100g	$106	2024-03-01	Buy
Sigma-Aldrich	W363421	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one solution 3?wt. % in propylene glycol	28664-35-9	1kg	$513	2024-03-01	Buy

Product number	Packaging	Price	Buy
W363499	SAMPLE-K	$220	Buy
W363499	25G	$292	Buy
W363499	100G	$819	Buy
W363421	100g	$106	Buy
W363421	1kg	$513	Buy

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Chemical Properties,Uses,Production

Chemical Properties

3-Hydroxy-4,5-dimethyl-2(5H)-furanone was found in, for example, fenugreek, coffee, sake, and florsherry. Its aroma characteristic changes from caramel-like at low concentrations to curry-like at high concentrations. A method described for its preparation comprises condensation of ethyl propionate with diethyl oxalate and reaction of the intermediately formed diethyl oxalylpropionate with acetaldehyde. Acidic decarboxylation of the ethyl 4,5-dimethyl-2,3-dioxodihydrofuran-4-carboxylate gives the title compound.

Chemical Properties

clear yellow liquid

Occurrence

Reported found in roasted Virginia tobacco, beef broth, beer, sherry, botryized wine, coffee, tea, fenugreek, sake and rice wine.

Uses

4,5-Dimethyl-3-hydroxy-2(5H)-furanone-13C3 is a labelled analogue of 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (D473600). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is a fragrant compound that is a key indicator of maple syrup urine disease, a disorder affecting newborn children that is the result of its inability to properly metabolize Valine (V094205), Leucine (L330110) and Isoleucine (I820175). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is naturally found in fenugreek seeds, and is an odourant present in sherry wines.

Definition

ChEBI: Sotolone is a butenolide. It has a role as a metabolite.

Aroma threshold values

Aroma characteristics at 1.0%; sweet, strong brown, cyclotene and maple like, caramel, toffee, maltol-like and burnt, brown sugar fenugreek-like, cooked and syrupy.

Taste threshold values

Taste characteristics at 5–25 ppm; sweet, caramel, maple, walnut, brown sugar, nutty, cotton candy, fenugreek and celery-like, rum, roasted meaty with a honey nuance

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Suppliers

Global( 238)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7786	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-28	Sugar lactone 28664-35-9	US $0.00 / KG	25KG	97%	Inquiry	PNP Biotech Co. Ltd
2024-03-26	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 28664-35-9	US $30.00-0.80 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-09-23	4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 28664-35-9	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

Sugar lactone
28664-35-9
US $0.00 / KG
97%
PNP Biotech Co. Ltd

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
28664-35-9
US $30.00-0.80 / kg
99%
Henan Fengda Chemical Co., Ltd

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
28664-35-9
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Spectrum

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one(28664-35-9)¹HNMR 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one(28664-35-9)FT-IR

28664-35-9(4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one)Related Search:

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4,5-DIMETHYL-3-HYDROXY-2,5-DIHYDROFURAN-2-ONE Fenugreck Lactone 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (ca. 14% in propylene glycol) SUGAR LACTONE PURE 4 5-DIMETHYL-3-HYDROXY-2 5-DIHYDROFURAN& 3-Hydroxy-4,5-Dimethyl-2(5H)-Furanone 28664-35-9 sotolon,3-hydroxy-4,5-dimethyl-2(5H)-furanone 4,5-dimethyl-3-hydroxy-2,5-dihydrofuran-2-one solution caramel furanone solution 4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE (CA. 10% IN PROPYLENE GLYCOL) 4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE, CA. 3% IN PROPYLENE GLYCOL 4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE 97% 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (ca. 14% in Propylene Glycol, ca. 1.2mol/L) CARAMEL FURANONE 0.1% IN P.G., NATURAL CARAMEL FURANONE IN 3% P.G. CARAMEL FURANONE, PURE 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one, Caramel furanone, Sotolon, Sugar lactone Caramel furanone, Sotolon, Sugar lactone 2,4-Dihydroxy-3,4-dimethyl-2-butenoic acid 1,4-lactone 4,5-Dimethyl-3-hydroxyfuran-2(5H)-one RI-2177 4,5-Dimethyl-3-hydroxy-2(5H)-furanone,98% 3-Hydoxy-4,5-dimethyl-2(5H)-furanone 2,3-DIMETHYL-4-HYDROXY-2,5-DIHYDROFURAN-5-ONE 4,5-dimethyl-3-hydroxy-2(5H)- furanone (sotolon) dimethylhydroxyfuranone Furan-2(5H)-one, 3-hydroxy-4,5-dimethyl- 3-hydroxy-4,5-dimethyl-5H-furan-2-one 4,5-dimethyl-3-hydroxy-2,5-dihydrofuran-2-one AKA sugar lactone CARAMEL FURANONE (3% IN TRIACETIN) 5-dihydrofuran-2-one 5-Dimethyl-3-hydroxy-2 4,5-Dimethyl-3-hydroxy-2(5H)-furanone, 97.5% ,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Fenugreeklactone 3% 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one/Sotolon 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one USP/EP/BP 3-HYDROXY-4,5-DIMETHYL-2(5H)-FURANONE 4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE FEMA 3634 FENUGREEK LACTONE CARAMEL FURANONE 3-hydroxy-4,5-dimethylfuran-2(5H)-one 2(5H)-Furanone, 3-hydroxy-4,5-dimethyl- 3-hydroxy-4,5-dimethyl-2(5h)-furanon 3-hydroxy-4,5-dimethyl-2(5H)-furanone (sotolon) SOTOLON SOTOLONE SUGAR LACTONE 4-hydroxy-2,3-dimethyl-2H-furan-5-one 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one（Sugar lactone） 28664-35-9 food additives food additive