Anti-Insulin antibody, Mouse monoclonal
- CAS No.
- Chemical Name:
- Anti-Insulin antibody, Mouse monoclonal
- Synonyms
- Anti-Insulin antibody, Mouse monoclonal
- CBNumber:
- CB64669360
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-Insulin antibody, Mouse monoclonal price More Price(1)
Anti-Insulin antibody, Mouse monoclonal Chemical Properties,Uses,Production
Uses
Anti-Insulin antibody, Mouse monoclonal has been used in immunohistochemistry.
General Description
The INS gene encodes for preproinsulin, which is enzymatically converted into insulin. Insulin is produced by the β cells in the Islets of Langerhans. Preproinsulin is converted to proinsulin in the endoplasmic reticulum and proinsulin is then proteolytically processed to form insulin in newly-forming insulin secretory granules. Insulin production is tightly regulated by specific DNA elements present within ~400 bp in the proximal region of the INS promoter.
Biochem/physiol Actions
Insulin is responsible for two types of actions- excitatory and inhibitory. In its excitatory role, it increases the uptake of glucose and lipid synthesis, and in its inhibitory role it inhibits glycogenolysis, gluconeogenesis, lipolysis, proteolysis and ketogenesis. Aberrant insulin secretion leads to various disorders such as diabetes, hyperglycemia or hypoglycemia. Mutant INS-gene Induced diabetes of youth (MIDY) syndrome is an autosomal dominant disorder caused by missense mutations, which lead to aberrant proinsulin folding. Impaired glucose tolerance (IGT) or non-insulin-dependent diabetes mellitus (NIDDM) is caused by resistance to insulin-stimulated glucose uptake.
Anti-Insulin antibody, Mouse monoclonal Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-Insulin antibody, Mouse monoclonal Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
---|---|
Sigma-Aldrich | 80 |