Anti-Talin antibody, Mouse monoclonal
- CAS No.
- Chemical Name:
- Anti-Talin antibody, Mouse monoclonal
- Synonyms
- Anti-Talin antibody, Mouse monoclonal
- CBNumber:
- CB64669744
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-Talin antibody, Mouse monoclonal price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SAB4200041 | Anti-Talin antibody,Mouse monoclonal clone TA205, purified from hybridoma cell culture | 200μL | $601 | 2024-03-01 | Buy | |
Sigma-Aldrich | SAB4200694 | Anti-Talin antibody, Mouse monoclonal clone 8D4, purified from?hybridoma?cell culture | 100μL | $479 | 2023-06-20 | Buy |
Anti-Talin antibody, Mouse monoclonal Chemical Properties,Uses,Production
Uses
Anti-Talin antibody, Mouse monoclonal has been used in:
- immunoblotting
- immunofluorescence
- fluorescence-activated cell sorting (FACS)
- enzyme-linked immunosorbent assay (ELISA)
General Description
Anti-Talin antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the hybridoma 8D4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified cytoskeletal Talin, from chicken gizzard. Talin is a high molecular weight cytoplasmic adapter protein. It is localized at a subset of adherens junctions. Talin contains an N-terminal FERM domain (the head) linked to a flexible rod comprised of 13 amphipathic helical bundles and a C-terminal helix (DD) that forms an anti-parallel dimer. It may be found either as monomer or dimer.
Biochem/physiol Actions
Talin 1 (TLN1) is a cytoskeletal protein, which plays a vital role in cancer cell adhesion, migration and invasion. It is also involved in integrin activation and it facilitates the adhesion of integrin to actin cytoskeleton. TLN1 might act as a potential prognostic biomarker in nasopharyngeal carcinoma (NPC). Overexpression of TLN1 is observed in endometrioid carcinoma, oral squamous cell carcinoma (OSCC), prostate cancer and hepatocellular carcinoma. Serum TLN1 functions as a potential biomarker of hepatocellular carcinoma (HCC). Talin 1 (TLN1) is highly expressed in glioblastoma multiforme (GBM). The inhibition of TLN1 activity helps in diminishing malignant features of GBM cells. It also plays an important role in regulation of, Bevacizumab (anti-angiogenic agent) -resistance.
Anti-Talin antibody, Mouse monoclonal Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-Talin antibody, Mouse monoclonal Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |