PFM01
- CAS No.
- 1558598-41-6
- Chemical Name:
- PFM01
- Synonyms
- PFM01;PFM01 ，S3549;PFM01 >=98% (HPLC);PFM01, 10 mM in DMSO;(Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one;(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)-;Inhibitor,derivative,MRE11,PFM-01,NHEJ,Mirin,DSB,endonuclease,N-alkylated,PFM01,PFM 01,inhibit
- CBNumber:
- CB64670537
- Molecular Formula:
- C14H15NO2S2
- Molecular Weight:
- 293.4
- MDL Number:
- MFCD02220972
- MOL File:
- 1558598-41-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| PFM01 ≥98% (HPLC) | SML1735 | 5mg | $116.85 |
| PFM01 ≥98% (HPLC) | SML1735 | 25mg | $333.9 |
| PFM01 ≥98%(HPLC) | 6222 | 50 | $315 |
| PFM01 ≥98%(HPLC) | 6222 | 10 | $75 |
| PFM01 | P293993 | 1mg | $45 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| NFPA 704 |
|
PFM01 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1735 | PFM01 ≥98% (HPLC) | 1558598-41-6 | 5mg | $116.85 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML1735 | PFM01 ≥98% (HPLC) | 1558598-41-6 | 25mg | $333.9 | 2025-07-31 | Buy |
| Tocris | 6222 | PFM01 ≥98%(HPLC) | 1558598-41-6 | 50 | $315 | 2021-12-16 | Buy |
| Tocris | 6222 | PFM01 ≥98%(HPLC) | 1558598-41-6 | 10 | $75 | 2021-12-16 | Buy |
| TRC | P293993 | PFM01 | 1558598-41-6 | 1mg | $45 | 2021-12-16 | Buy |
PFM01 Chemical Properties,Uses,Production
Uses
PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR)[1][2].
Biochem/physiol Actions
PFM01 is a cell-permeable N-alkylated Mirin (Sigma Cat. No. 475954) derivative that selectively inhibits against MRE11 endo-, but not exo-, nuclease activity. PFM01 targets MRE11 at a site near the dimer interface, distinct from that occupied by Mirin and PFM39 to allow disruption of the ssDNA-binding groove and selective inhibition against MRE11 endo-, but not exo-, nuclease activity. While both endonuclease and exonuclease activities are required for MRE11-mediated homologous recombination (HR) repair, only FM01 (100 μM), but not the exonuclease inhibitors Mirin (500 μM) and PFM39 (100 μM), rescues G2-phase double-strand break (DSB) repair defect in HR protein BRCA2-deficient HSC62-hTERT fibroblasts following ionizing irradiation (IR) by blocking HR initiation and thereby allowing non-homologous end joining (NHEJ) to proceed.
storage
Store at -20°C
References
[1] Shibata A, et, al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9; 53(1): 7-18. DOI:10.1016/j.molcel.2013.11.003
[2] V?lkening L, et, al. RAD50 regulates mitotic progression independent of DNA repair functions. FASEB J. 2020 Feb; 34(2): 2812-2820. DOI:10.1096/fj.201902318R
PFM01 Preparation Products And Raw materials
Raw materials
Preparation Products
PFM01 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-846993838003-8003 18013301590 | njduly@126.com | China | 3251 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
