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Pimobendan

Pimobendan Structure
Pimobendan structure
CAS No.
74150-27-9
Chemical Name:
Pimobendan
Synonyms
VetMedin;(5RS)-6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5- methyl-4,5-dihydropyridazin-3(2H)-one;Acardi;UD-CG 115;PIMOBENDAN;Pimobendam;Pimobendane;UD-CG 115BS;Pimobendanum;PiMobendan EP
CBNumber:
CB6472876
Molecular Formula:
C19H18N4O2
Molecular Weight:
334.37
MDL Number:
MFCD00761648
MOL File:
74150-27-9.mol
MSDS File:
SDS
Last updated:2024-04-03 17:07:09
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Pimobendan Properties

Melting point approximate 243℃ (dec.)
Density 1.36
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
form powder
pka 10.55±0.10(Predicted)
color white to beige
InChI InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
InChIKey GLBJJMFZWDBELO-UHFFFAOYSA-N
SMILES C1(=O)NN=C(C2C=C3NC(C4=CC=C(OC)C=C4)=NC3=CC=2)C(C)C1
CAS DataBase Reference 74150-27-9(CAS DataBase Reference)
FDA UNII 34AP3BBP9T

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310+P330
RIDADR  UN 2811 6.1 / PGIII
HS Code  2933995300
NFPA 704
0
2 0

Pimobendan price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1333 Pimobendan for system suitability ≥98% (HPLC) 74150-27-9 10mg $118 2024-03-01 Buy
Sigma-Aldrich PHR3084 Pimobendan pharmaceutical secondary standard, certified reference material 74150-27-9 200MG $518 2024-03-01 Buy
Sigma-Aldrich BP1247 Pimobendan British Pharmacopoeia (BP) Reference Standard 74150-27-9 100MG $275 2024-03-01 Buy
Sigma-Aldrich 1569315 Pimobendan for system suitability United States Pharmacopeia (USP) Reference Standard 74150-27-9 100mg $1120 2024-03-01 Buy
Cayman Chemical 26082 Pimobendan 74150-27-9 50mg $98 2024-03-01 Buy
Product number Packaging Price Buy
SML1333 10mg $118 Buy
PHR3084 200MG $518 Buy
BP1247 100MG $275 Buy
1569315 100mg $1120 Buy
26082 50mg $98 Buy

Pimobendan Chemical Properties,Uses,Production

Description

Pimobendan, a novel cardiotonic vasodilator, was introduced in Japan for the treatment of acute and mild to moderate chronic heart failure. It is a phosphodiesterase Ⅲ inhibitor and is able to enhance sensitization of myocardial contractile regulatory protein to calcium ions. The combination of these effects contribute to its inotropic activity. In patients with severe congestive heart failure, orally administered pimobendan improves cardiac index, stroke volume index, pulmonary wedge pressure, and systemic and pulmonary vascular resistance. Pimobendan is reported to be well tolerated and largely devoid of the proarrhythmic effects of classical phosphodiesterase Ill inhibitors. Studies also suggested that combination of the inotropic agent pimobendan with an ACE inhibitor such as enalapril may be superior to monotherapy for heart failure patients.

Chemical Properties

White Solid

Originator

Boehringer lngelhelm (Germany)

Uses

Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.

Uses

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. It is a drug with both inotropic and vasodilatory properties that is used for the treatment of var-ious cardiac diseases.

Definition

ChEBI: Pimobendan is a pyridazinone and a member of benzimidazoles. It has a role as a cardiotonic drug, a vasodilator agent and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

brand name

Acardl

Biological Activity

Pimobendan is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 0.32 μM for guinea pig cardiac enzyme) that is selective for PDE3 over PDE1, PDE2, and PDE4 (IC50s = >30 μM). It is also a calcium sensitizer, decreasing the concentration of calcium required for half-maximal contractile force in isolated, skinned porcine ventricular fibers. Pimobendan increases the force of contraction in electrically-stimulated isolated guinea pig papillary muscles with an EC50 value of 6 μM, indicating positive inotropic effects. It increases survival time in dogs with congestive heart failure due to myxomatous mitral valve disease when administered in combination with angiotensin-converting enzyme inhibitors and furosemide . Formulations containing pimobendan have been used in the treatment of heart failure in dogs.

Biochem/physiol Actions

Pimobendan is an inotropic agent with a dual mechanism of action: it increases myocardial contractility by increasing calcium sensitization to troponin C and it promotes vasodilation by inhibiting phosphodiesterase III (PDE3). Pimobendan has been studied for treating heart failure and cardiomyopathy, primarily for veterinary uses.

Mechanism of action

The mechanism of mild mitral regurgitation (MR) in dogs treated with Pimobendan is a dual mechanism of action, which enhances myocardial contractility by increasing calcium sensitisation of troponin C and promotes vasodilatation by inhibiting PDEIII.

Side effects

The most common side effects include gastrointestinal effects such as decreased appetite, and diarrhea. Other possible side effects include lethargy and difficulty breathing This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.

Veterinary Drugs and Treatments

Pimobendan is used to treat dogs with congestive heart failure secondary to dilated cardiomyopathy or chronic mitral valve insufficiency (CMVI).

in vitro

In vitro, pimobendan was O-demethylated and subsequently O-glucuronidated. The rate of metabolism of pimobendan could be maintained in this culture system for > 3 weeks. However, the relative amount of a putative N-glucuronide under in vitro conditions was lower than in vivo[1].

References

[1] S A Pahernik. “Metabolism of pimobendan in long-term human hepatocyte culture: in vivo-in vitro comparison.” Xenobiotica 25 8 (1995): 811–23.

Pimobendan synthesis

123-11-5
74150-02-0
74150-27-9
Synthesis of Pimobendan from p-Anisaldehyde and 6-(3,4-diaminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

Pimobendan Preparation Products And Raw materials

Raw materials

2-N-BUTOXYETHYL METHACRYLATE 2-BENZOYLACETANILIDE Ethanol Propionyl chloride Formaldehyde
Aluminum chloride Iodomethane POTASSIUM CYANIDE

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Preparation Products

Pimobendan Suppliers

Global( 306)Suppliers
Supplier Tel Email Country ProdList Advantage
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd 		+86-02223869539 +86-15560057295 trade.kilopharma@foxmail.com China 27 58
Hpets Biotech Company (Chongqing) Co.,ltd
+8613340353813 info@hanpets.com China 26 58
Liaoning Pharmaceutical Innovation Co., Ltd
+8616588669988 sales@pipharma.com.cn China 148 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12457 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 1000 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7613 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 885 50
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Supplier Advantage
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd 		58
Hpets Biotech Company (Chongqing) Co.,ltd
58
Liaoning Pharmaceutical Innovation Co., Ltd
58
Hebei Mojin Biotechnology Co., Ltd 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55

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View Lastest Price from Pimobendan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pimobendan pictures 2024-04-22 Pimobendan
74150-27-9
 US $0.00 / Kg/Bag 2Kg/Bag 98% up EP / CEP 20 tons Sinoway Industrial co., ltd.
Pimobendan pictures 2024-04-12 Pimobendan
74150-27-9
 US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
pimobendan pictures 2024-04-03 pimobendan
74150-27-9
 US $0.00-0.00 / g 1g 99.9% 500KGS Liaoning Pharmaceutical Innovation Co., Ltd
  • Pimobendan pictures
  • Pimobendan
    74150-27-9
  • US $0.00 / Kg/Bag
  • 98% up EP / CEP
  • Sinoway Industrial co., ltd.
  • Pimobendan pictures
  • Pimobendan
    74150-27-9
  • US $0.00 / kg
  • 99%
  • Shaanxi Haibo Biotechnology Co., Ltd
  • pimobendan pictures
  • pimobendan
    74150-27-9
  • US $0.00-0.00 / g
  • 99.9%
  • Liaoning Pharmaceutical Innovation Co., Ltd

Pimobendan Spectrum

Pimobendan(74150-27-9)1HNMR

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4,5-dihydro-6-[2-(4-methoxyphenyl)-1h-benzimidazol-5-yl]-5-methyl-3(2h)-pyridazinone 6-(2-(4-methoxyphenyl)-1H-benzo[d]imidazol-6-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one 6-(2-(4-Methoxyphenyl)-4,5-dihydro-1H-benzimidazol-5-yl)-5-methyl-3(2H)-pyridazinone Pimobendan [inn-spanish] Pimobendane Pimobendane [inn-french] Pimobendanum PiMobendan(VetMedin) 4,5-Dihydro-6-[2-(4-Methoxyphenyl)-1H-benziMidazol-6-yl]-5-Methyl- 3(2H)-pyridazinone Acardi rac PiMobendan PiMobendan EP 6-[2-(4-Methoxy-phenyl)-1H-benzoiMidazol-5-yl]-5-Methyl-4,5-dihydro-2H-pyridazin-3-one 6-(2-(4-Methoxyphenyl)-1H-benzo[d]iMidazol-5-yl)-5-Methyl-4,5-dihydropyridazin-3(2H)-one PIMOBENDAN 3(2H)-Pyridazinone,4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl- 4，5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-y1]-5-methyl-3(2H)-pyridazinone PIMOBENDANE HCL Pimobendam 3(2H)-Pyridazinone, 4,5-dihydro-6-2-(4-methoxyphenyl)-1H-benzimidazol-5-yl-5-methyl- 3(2H)-Pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl- (9CI) dl-Pimobendan Racemic pimobendan UD-CG 115 UD-CG 115BS VETMEDIN; ACARDI; PIMOBENDANE 2-(2-Methyl-1-oxopropyl)isoindole-1,3-dione Pimobendan CRS Pimobendan for system suitability CRS 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone Pimobendan USP/EP/BP Pimobendan 13CD3Q: What is Pimobendan 13CD3 Q: What is the CAS Number of Pimobendan 13CD3 Pimobendan D3Q: What is Pimobendan D3 Q: What is the CAS Number of Pimobendan D3 Pimobendan-D4 Pimobendan (1569315) (5RS)-6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5- methyl-4,5-dihydropyridazin-3(2H)-one VetMedin Pimobendan/UD-CG115 74150-27-9 7415-27-9 C19H18N4O2 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Inhibitor Acardi, pimobendane API 74150-27-9