4,6-Dichloropyrimidine
- CAS No.
- 1193-21-1
- Chemical Name:
- 4,6-Dichloropyrimidine
- Synonyms
- NSC 37530;4,6-DichL;DichloropyriMidine;IFLAB-BB F2124-0077;4,6-Dichloropyrimidi;4,6-Dichloropyridine;4,6-Dichlorpyrimidin;4,6-Dichoropyrimidine;4,6-DICHLOROPYRIMIDINE;4,6-Dichloro-1,3-diazine
- CBNumber:
- CB6473590
- Molecular Formula:
- C4H2Cl2N2
- Molecular Weight:
- 148.98
- MDL Number:
- MFCD00006109
- MOL File:
- 1193-21-1.mol
- MSDS File:
- SDS
| Melting point | 65-67 °C (lit.) |
|---|---|
| Boiling point | 176 °C (lit.) |
| Density | 1.6445 (rough estimate) |
| vapor pressure | 30-390Pa at 20-50℃ |
| refractive index | 1.6300 (estimate) |
| Flash point | 176°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow |
| pka | -4.20±0.17(Predicted) |
| form | Crystals |
| color | Yellow-green |
| BRN | 111195 |
| InChIKey | XJPZKYIHCLDXST-UHFFFAOYSA-N |
| LogP | 1.45 at 25℃ and pH7.2 |
| Surface tension | 65.72mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 1193-21-1(CAS DataBase Reference) |
| FDA UNII | TTE9SA8H44 |
| NIST Chemistry Reference | Pyrimidine, 4,6-dichloro-(1193-21-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-20/21/22-36/37 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3263 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
4,6-Dichloropyrimidine price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 145378 | 4,6-Dichloropyrimidine 97% | 1193-21-1 | 10g | $91.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 145378 | 4,6-Dichloropyrimidine 97% | 1193-21-1 | 50g | $126.8 | 2024-03-01 | Buy |
| TCI Chemical | D2488 | 4,6-Dichloropyrimidine >98.0%(GC) | 1193-21-1 | 5g | $16 | 2024-03-01 | Buy |
| TCI Chemical | D2488 | 4,6-Dichloropyrimidine >98.0%(GC) | 1193-21-1 | 25g | $44 | 2024-03-01 | Buy |
| Alfa Aesar | L13212 | 4,6-Dichloropyrimidine, 98% | 1193-21-1 | 25g | $133.65 | 2024-03-01 | Buy |
4,6-Dichloropyrimidine Chemical Properties,Uses,Production
Uses
4,6-Dichloropyrimidine (cas# 1193-21-1) is a compound useful in organic synthesis.
Chemical Properties
Yellow Solid
Uses
4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.
General Description
Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.
Synthesis
The synthesis of 4,6-Dichloropyrimidine is as follows:Dissolve 105.5g of 4,6-diaminopyrimidine in 660.0g of 31% hydrochloric acid and pour into a 2000ml bottle to cool to -5 ° C and dropwise add 500.3g of 33% sodium nitrite. After 2 hours of reaction, HPLC detects 4,6-diamino Pyrimidine is less than 0.5%. 42.8 g of cuprous chloride and 214.0 g of 31% hydrochloric acid are prepared in a 2000 ml bottle. The diazonium salt mother liquor is added dropwise to the bottle. After the dropwise reaction, the reaction is performed at 45 ° C for 2 hours. .Extract with 400g of recovered trichloroethane (200x2 times less than new ones), combine the organic layers for distillation, control the water flush pump 5KPa, temperature 40-140 , collect 404.2g of solvent in the early 40-90 , 90-140 in the later The product was collected at a temperature of 14 ° C to obtain 146.9 g of 4,6-dichloropyrimidine. The yield was 86.4% (based on formazan hydrochloride) and the purity was 99.4%.
4,6-Dichloropyrimidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Aoliqisi New Material Technology Co., Ltd. | +86-13545906766; +8613545906766 | sales@whaop.com | China | 265 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5905 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5964 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from 4,6-Dichloropyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-11-21 | 4,6-Dichloropyrimidine
1193-21-1
|
US $30.00 / g | 1000g | 99% | 20ton/month | Wuhan Aoliqisi New Material Technology Co., Ltd. | |
 |
2023-11-21 | 4,6-Dichloropyrimidine
1193-21-1
|
US $30.00 / g | 1000g | 99% | 20ton/month | Wuhan Aoliqisi New Material Technology Co., Ltd. | |
 |
2023-09-25 | 4,6-dichloropyrimidine
1193-21-1
|
US $140.00 / g | 1g | 99.99% | 2000 KG | Anhui Yisheng Technology Co., LTD |
-
- 4,6-Dichloropyrimidine
1193-21-1
- US $30.00 / g
- 99%
- Wuhan Aoliqisi New Material Technology Co., Ltd.
-
- 4,6-Dichloropyrimidine
1193-21-1
- US $30.00 / g
- 99%
- Wuhan Aoliqisi New Material Technology Co., Ltd.
-
- 4,6-dichloropyrimidine
1193-21-1
- US $140.00 / g
- 99.99%
- Anhui Yisheng Technology Co., LTD
1193-21-1(4,6-Dichloropyrimidine)Related Search:
1of4