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Pivaloyl chloride

Pivaloyl chloride
Pivaloyl chloride structure
Chemical Name:
Pivaloyl chloride
PVCL;pivaloyl;221-921-6;Trimethylacetyl;Pivaloylchlorid;Pyvaloylchloride;PIVALYL CHLORIDE;Pivaloyl chlorode;PIVALOYL CHLORIDE;Pivalpyl chloride
Molecular Formula:
Formula Weight:
MOL File:

Pivaloyl chloride Properties

Melting point:
-56 °C
Boiling point:
105-106 °C(lit.)
0.980 g/mL at 20 °C
vapor density 
>1 (vs air)
vapor pressure 
36 mm Hg ( 20 °C)
refractive index 
n20/D 1.412(lit.)
Flash point:
48 °F
storage temp. 
Store at RT.
Miscible with acetonitrile.
Clear almost colorless to light pink
explosive limit
Water Solubility 
Moisture Sensitive
CAS DataBase Reference
3282-30-2(CAS DataBase Reference)
NIST Chemistry Reference
Propanoyl chloride, 2,2-dimethyl-(3282-30-2)
EPA Substance Registry System
Propanoyl chloride, 2,2-dimethyl-(3282-30-2)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,T+,T
Risk Statements  11-14-22-26-34-23
Safety Statements  16-26-36/37/39-45-38-28A
RIDADR  UN 2438 6.1/PG 1
WGK Germany  1
HazardClass  6.1
PackingGroup  I
HS Code  29159080
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P320 Specific treatment is urgent (see … on this label).
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Pivaloyl chloride price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T72605 Trimethylacetyl chloride 99% 3282-30-2 5ml $18.6 2018-11-20 Buy
Sigma-Aldrich T72605 Trimethylacetyl chloride 99% 3282-30-2 100ml $18.7 2018-11-20 Buy
Alfa Aesar A15051 Trimethylacetyl chloride, 98+% 3282-30-2 500ml $52.1 2018-11-13 Buy
Alfa Aesar A15051 Trimethylacetyl chloride, 98+% 3282-30-2 100ml $15.2 2018-11-13 Buy
Sigma-Aldrich T72605 Trimethylacetyl chloride 99% 3282-30-2 500ml $62.3 2018-11-20 Buy

Pivaloyl chloride Chemical Properties,Uses,Production

Chemical Properties

Colorless to yellow liquid


Widely used N-acylating agent for amines,1 Schiff bases,2 and pyrrolidinones3 as well as O-acylating agent for alcohols,4 lactones,5 and saccharides.6

General Description

Colorless fuming liquid with a pungent odor. Boiling point 105-106°F. Density 0.979 g / cm3. Flash point 48°F (8°C). Very toxic by inhalation, ingestion or skin absorption. Fumes irritate the eyes and mucous membranes. Corrosive to most metals and tissue.

Air & Water Reactions

Highly flammable. Fumes in air. Reacts vigorously and exothermically with water to form trimethylacetic acid and corrosive hydrochloric acid; both acids corrode metals and tissue [AAR 1991].

Reactivity Profile

Pivaloyl chloride is acidic. Incompatible with bases (including amines), strong oxidizing agents, and alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

A corrosive irritant to skin, eyes, and mucous membranes. The liquid is flammable when exposed to heat, flame, or oxiduers. When heated to decomposition it emits toxic fumes of Cl-.

Purification Methods

First check the IR to see if OH bands are present. If absent, or present in small amounts, then redistil it under a moderate vacuum. If present in large amounts then treat it with oxalyl chloride or thionyl chloride and reflux for 2-3hours, evaporate and distil the residue. Strongly LACHRYMATORY -work in a fumecupboard. Store it in sealed ampoules under N2. [Traynham & Battiste J Org Chem 22 1551 1957, Grignard reactions: Whitmore et al. J Am Chem Soc 63 647 1941, Beilstein 2 IV 912.]

Pivaloyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Pivaloyl chloride Suppliers

Global( 272)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Speranza Chemical Co., Ltd.
+86-755-33122716 CHINA 171 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21930 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37127788 CHINA 495 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880086 CHINA 558 58
career henan chemical co
+86-371-86658258 CHINA 20516 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20094 58
Jinan Finer Chemical Co., Ltd
+86-531-88989539 CHINA 939 58

View Lastest Price from Pivaloyl chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-21 Pivaloyl chloride
US $7.00 / kg 1kg 99% 100kg career henan chemical co
2018-12-21 Pivaloyl chloride
US $1.00 / kg 1kg 99% as request career henan chemical co

Pivaloyl chloride Spectrum

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