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Mercaptoacetic acid

Mercaptoacetic acid
Mercaptoacetic acid structure
Chemical Name:
Mercaptoacetic acid
TGA;Thiog;usafcb-35;MEQUINDOX;USAF cb-35;ic acid soL;thioglycolic;thiovanicacid;Thioglycolate;Thiovanie acid
Molecular Formula:
Formula Weight:
MOL File:

Mercaptoacetic acid Properties

Melting point:
−16 °C(lit.)
Boiling point:
96 °C5 mm Hg(lit.)
1.326 g/mL at 20 °C(lit.)
vapor density 
3.2 (vs air)
vapor pressure 
0.4 mm Hg ( 25 °C)
refractive index 
n20/D 1.505(lit.)
Flash point:
126 °C
storage temp. 
3.68(at 25℃)
clear clear, colorless
1 (H2O, 20℃)
Water Solubility 
Air Sensitive
Exposure limits
TLV-TWA 1 ppm (~3.8 mg/m3) (ACGIH).
CAS DataBase Reference
68-11-1(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
Acetic acid, mercapto-(68-11-1)
EPA Substance Registry System
Thioglycolic acid (68-11-1)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H301+H331-H312-H314-H301+H311+H331-H290-H301+H311-H317-H330-H370-H402-H301-H311-H331
Precautionary statements  P234-P260-P264-P270-P271-P272-P273-P284-P301+P330+P331+P310-P303+P361+P353+P310+P363-P305+P351+P338+P310-P307+P311-P390-P405-P406-P501-P260h-P301+P310a-P501a-P261-P301+P310+P330-P303+P361+P353-P304+P340+P310-P305+P351+P338-P403+P233-P280
Hazard Codes  T,T+
Risk Statements  23/24/25-34-26-24/25
Safety Statements  25-27-28-45-36/37-28C-23
RIDADR  UN 1940 8/PG 2
WGK Germany  1
RTECS  AI5950000
Autoignition Temperature 662 °F
HazardClass  8
PackingGroup  II
HS Code  29309070
Toxicity LD50 orally in rats: 0.15 ml/kg (Deichmann, Mergard)
NFPA 704
3 0

Mercaptoacetic acid price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 528056 Thioglycolic acid ≥99% 68-11-1 100ml $38.7 2020-08-18 Buy
Sigma-Aldrich 88652 Thioglycolic acid solution ~80% in H 68-11-1 1l $110 2020-08-18 Buy
TCI Chemical M0052 Thioglycolic Acid >98.0%(T) 68-11-1 25g $14 2020-06-24 Buy
TCI Chemical M0052 Thioglycolic Acid >98.0%(T) 68-11-1 500g $38 2020-06-24 Buy
Alfa Aesar B20391 Mercaptoacetic acid, 97+% 68-11-1 100g $25.4 2020-06-24 Buy

Mercaptoacetic acid Chemical Properties,Uses,Production


Thio glycolic acid (TGA) is the organic compound HSCH2CO2H . It contains both a thiol (mercaptan) and a carboxylic acid. It is a clear liquid with a strong unpleasant odor. It is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
TGA was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate. TGA is the precursor to ammonium thioglycolate that is used for permanents. TGA and its derivatives break the disulfide bonds in the cortex of hair. One reforms these broken bonds in giving hair a "perm." Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing. It is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
TGA is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).
TGA, usually as its dianion, forms complexes with metal ions. Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Thioglycolic acid is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.

Chemical Properties

Thioglycolic acid is a colorless liquid with a strong unpleasant odor like rotten eggs.

Chemical Properties

Also known as mercaptoacetic acid, HSCH2COOH is a colorless liquid with a strong unpleasant odor. Used as a reagent for metals such as iron, molybdenum, silver, and tin,and in bacteriology.


Thioglycolic Acid is an organic compound containing both a thiol and a carboxylic acid. Thioglycolic Acid is a precursor to ammonium thioglycolate, a chemical used for permanents. Thioglycolic Acid is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.


Sensitive reagent for iron, molybdenum, silver, tin. With ferric iron a blue color appears, and when an alkali hydroxide is added to a solution contg ferrous salts and thioglycolic acid, a yellow precipitate forms. Used in the manufacture of thioglycolates. The ammonium and sodium salts are commonly used for cold waving and the calcium salt is a depilatory. The sodium salt also is used in bacteriology in the preparation of thioglycolate media.


Mercaptoacetic acid is used as a reagent formetals analysis; in the manufacture of thioglycolates, pharmaceuticals, and permanentwave solutions; and as a vinyl stabilizer.

General Description

A colorless liquid with an unpleasant odor. Density 1.325 g / cm3. Used to make permanent wave solutions and depilatories. Corrosive to metals and tissue.

Air & Water Reactions

Readily oxidized by air. Water soluble.

Reactivity Profile

Mercaptoacetic acid is readily oxidized by air . Reacts readily with other oxidizing agents as well in reactions that may generate toxic gases. Incompatible with diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials may generate heat and toxic and flammable gases. May react with acids to liberate hydrogen sulfide. Neutralizes bases in exothermic reactions. Reacts with cyanides, sulfites, nitrites, thiosulfates to generate flammable and toxic gases and heat. Reacts with carbonates and bicarbonates.


Toxic by ingestion and inhalation, strong irritant to tissue, eyes, and skin.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Health Hazard

Mercaptoacetic acid is a highly toxic and ablistering compound. Even a 10% solutionwas lethal to most experimental animals by dermal absorption. The oral LD50 value ofundiluted acid is less than 50 mg/kg (Patty1963). The lethal dose in rabbits by skinabsorption is 300 mg/kg. The acute toxicsymptoms in test animals include weakness,respiratory distress, convulsions, irritation ofthe gastrointestinal tract, and liver damage.
Mercaptoacetic acid is a severe irritant.Contact with eyes can cause conjunctivalinflammation and corneal opacity. Skin contact can result in burns and necrosis.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. A corrosive irritant to skin, eyes, and mucous membranes. When heated to decomposition it emits toxic fumes of SOx. See also MERCAPTANS and HYDROGEN SULFIDE.

Potential Exposure

Thioglycolic acid is used to make thioglycolates; in sensitivity tests for iron; in formulations of permanent wave solutions and depilatories; in pharmaceutical manufacture; as a stabilizer in vinyl plastics.


Thioglycolic acid was not mutagenic in a number of Salmonella typhimurium strains with or without metabolic activation.


UN1940 Thyoglycolic acid, Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Mix the acid with an equal volume of *benzene; the *benzene is then distilled off to dehydrate the acid. After heating to 100o to remove most of the *benzene, the residue is distilled under vacuum and stored in sealed ampoules at 3o. [Eshelman et al. Anal Chem 22 844 1960, Beilstein 3 IV 1130.]


Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Air, strong oxidizers; bases, active metals, for example, sodium potassium, magnesium, and calcium. Readily oxidized by air. Thermal decomposition causes release of hydrogen sulfide. May attack various metals.

Waste Disposal

Dissolve in flammable solvent and burn in furnace equipped with afterburner and alkaline scrubber.

Mercaptoacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Mercaptoacetic acid Suppliers

Global( 258)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5917 58
Hebei Yanxi Chemical Co., Ltd.
86-311-66561638 CHINA 519 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21842 58
Hangzhou Bayee Chemical Co., Ltd.
0086-571-85775919 China 105 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22625 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 2754 55
career henan chemical co
+86-371-86658258 CHINA 30039 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28231 58
Jinan Finer Chemical Co., Ltd
+86-531-88989539 CHINA 998 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 10126 58

View Lastest Price from Mercaptoacetic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-09-21 Mercaptoacetic acid
US $4.00 / Kg/Drum 200Kg/Drum 99% 400t Jinan Qinmu Fine Chemical Co.,Ltd.
2020-07-13 Thioglycolate Acid
US $8.00 / Kg/Drum 260KG 98% 200 ton Hebei Yanxi Chemical Co., Ltd.
2020-07-22 Mercaptoacetic acid;Thioglycolic acid
US $4.00 / Kg/Drum 1T 99%;90%;80% 1000tons/month Hebei Yanxi Chemical Co., Ltd.

Mercaptoacetic acid Spectrum

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