DSIP
- CAS No.
- 62568-57-4
- Chemical Name:
- DSIP
- Synonyms
- DSIP;WAGGDASGE;DSIP 4H2O;EMIDELTIDE;Delta-Sleep;DSIP acetate;Etipolypeptide;DSIP USP/EP/BP;Ftpp/Adipotide;DSIP nonapeptide
- CBNumber:
- CB6478191
- Molecular Formula:
- C35H48N10O15
- Molecular Weight:
- 848.82
- MDL Number:
- MFCD00076883
- MOL File:
- 62568-57-4.mol
Boiling point | 1522.7±65.0 °C(Predicted) |
---|---|
Density | 1.458±0.06 g/cm3(Predicted) |
storage temp. | −20°C |
form | Powder |
pka | 3.18±0.10(Predicted) |
color | White to off-white |
Water Solubility | Soluble in water at 0.5mg/ml |
Sequence | H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH |
InChIKey | ZRZROXNBKJAOKB-GFVHOAGBSA-N |
FDA UNII | YN28Z5YZ73 |
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
---|---|
WGK Germany | 3 |
DSIP price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | D4072 | Delta Sleep Inducing Peptide | 62568-57-4 | 5mg | $142 | 2024-03-01 | Buy |
Sigma-Aldrich | D4072 | Delta Sleep Inducing Peptide | 62568-57-4 | 25mg | $218.4 | 2024-03-01 | Buy |
Alfa Aesar | J63334 | Delta Sleep-Inducing Peptide | 62568-57-4 | 1mg | $34.5 | 2021-12-16 | Buy |
Alfa Aesar | J63334 | Delta Sleep-Inducing Peptide | 62568-57-4 | 5mg | $118 | 2021-12-16 | Buy |
Usbiological | D2732-01B | Delta Sleep Inducing Peptide | 62568-57-4 | 25mg | $809 | 2021-12-16 | Buy |
DSIP Chemical Properties,Uses,Production
Description
Delta-sleep-inducing peptide (DSIP) is a neuropeptide with amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and molecular mass 848.81 g/mol. DSIP occurs in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). Delta-sleep-inducing peptide is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.
Uses
Delta-sleep-inducing peptide (DSIP) was isolated, characterized, and synthesized more than 6 years ago. It can help relieve stress and aches that keep you from restful sleep. It was first proposed as a sleep-peptide and this remains the prevalent impression of its function. DSIP is a natural sleep-promoting nonapeptide with a few beneficial functions. The peptide has been used to treat poor sleep, pain conditions, stress-related symptoms, and more. Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt is a useful research chemical compound.
Uses
DSIP is thought to increase sleep regulation, reduce motor activity to improve deep sleep, stimulate ACTH and LH levels, and reportedly normalize blood pressure. DSIP can change the serum level of some hormones, such as adrenocorticotropic hormone, somatostatin, serotonin, etc.
Definition
Emideltide or DSIP is a nonapeptide that is found in neurons, peripheral organs, and plasma. This neuropeptide induces mainly delta sleep in mammals. In addition to sleep, the peptide has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.
benefits
Can restore disturbed sleep patterns;Can promote LH and GH release;Can reduce persistent/chronic pain;Can modulate cortisol production.
benefits
Delta sleep-inducing peptide (DSIP), which suppresses excess production of free radicals in the CNS and prevents neuron death during the body’s response to stress. DSIP activates oxidative phosphorylation and increases the resistance of brain neurons to hypoxia in vitro. It decreases the sensitivity of neuron receptors to the excitatory actions of glutamate. Thus, DSIP helps to prevent excitotoxicity, which may underlie its neuroprotective action in cerebral ischemia[1].
References
[1] E. Koplik. “Delta sleep-inducing peptide and Deltaran: Potential approaches to antistress protection.” Neuroscience and Behavioral Physiology 38 1 (2008): 953–957.
Physiological effects
Delta sleep-inducing peptide (DSIP) has several physiological effects in addition to its ability to promote sleep in animals. It is also involved in neuroendocrine regulation and release of anterior pituitary hormones. In rodents and humans, Delta sleep-inducing peptide (DSIP) influence in the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and growth hormone (GH). It also plays a role in the regulation of the circadian rhythms and and can help restore disturbed patterns of sleep.
DSIP Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1000 | 58 |
Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 | sales@cellwh.com | China | 376 | 58 |
Zhuzhou New Peptides Tech Co.,Ltd. | +86-18073326374 +86-18073326374 | sales@goodpeptides.com | China | 56 | 58 |
Apextide Co Ltd | +86-15300650552 +86-15300650552 | info@apextide.com | China | 92 | 58 |
zhuzhou dingcheng meihei comestic co.,ltd | +8618873369619 | dingchengbusiness8@163.com | China | 260 | 58 |
Apeloa production Co.,Limited | +8619933239880 | admin@apcl.com.cn | China | 852 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3512 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12835 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3105 | 58 |
Related Qustion
- Q:Is DSIP Delta-Sleep-Inducing Peptide Safety?
- A:However, like any peptide, DSIP has a few potential side effects. These may include headaches, dizziness, and gastrointestinal....
- May 15,2024
View Lastest Price from DSIP manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-11-09 | DSIP
62568-57-4
|
US $1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD | ||
2024-11-09 | DSIP
62568-57-4
|
US $99.00-66.00 / kg | 0.001kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | ||
2024-11-08 | DSIP
62568-57-4
|
US $0.00 / G | 1G | 99% | 20 | CONTIDE BIOTECH CO.,LTD |
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