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DSIP

CAS No.
62568-57-4
Chemical Name:
DSIP
Synonyms
DSIP;WAGGDASGE;DSIP 4H2O;EMIDELTIDE;Delta-Sleep;DSIP acetate;Etipolypeptide;DSIP USP/EP/BP;Ftpp/Adipotide;DSIP nonapeptide
CBNumber:
CB6478191
Molecular Formula:
C35H48N10O15
Molecular Weight:
848.82
MDL Number:
MFCD00076883
MOL File:
62568-57-4.mol
Last updated:2024-10-29 18:21:28

DSIP Properties

Boiling point 1522.7±65.0 °C(Predicted)
Density 1.458±0.06 g/cm3(Predicted)
storage temp. −20°C
form Powder
pka 3.18±0.10(Predicted)
color White to off-white
Water Solubility Soluble in water at 0.5mg/ml
Sequence H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
InChIKey ZRZROXNBKJAOKB-GFVHOAGBSA-N
FDA UNII YN28Z5YZ73

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

DSIP price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D4072 Delta Sleep Inducing Peptide 62568-57-4 5mg $142 2024-03-01 Buy
Sigma-Aldrich D4072 Delta Sleep Inducing Peptide 62568-57-4 25mg $218.4 2024-03-01 Buy
Alfa Aesar J63334 Delta Sleep-Inducing Peptide 62568-57-4 1mg $34.5 2021-12-16 Buy
Alfa Aesar J63334 Delta Sleep-Inducing Peptide 62568-57-4 5mg $118 2021-12-16 Buy
Usbiological D2732-01B Delta Sleep Inducing Peptide 62568-57-4 25mg $809 2021-12-16 Buy
Product number Packaging Price Buy
D4072 5mg $142 Buy
D4072 25mg $218.4 Buy
J63334 1mg $34.5 Buy
J63334 5mg $118 Buy
D2732-01B 25mg $809 Buy

DSIP Chemical Properties,Uses,Production

Description

Delta-sleep-inducing peptide (DSIP) is a neuropeptide with amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and molecular mass 848.81 g/mol. DSIP occurs in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). Delta-sleep-inducing peptide is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.

Uses

Delta-sleep-inducing peptide (DSIP) was isolated, characterized, and synthesized more than 6 years ago. It can help relieve stress and aches that keep you from restful sleep. It was first proposed as a sleep-peptide and this remains the prevalent impression of its function. DSIP is a natural sleep-promoting nonapeptide with a few beneficial functions. The peptide has been used to treat poor sleep, pain conditions, stress-related symptoms, and more. Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt is a useful research chemical compound.

Uses

DSIP is thought to increase sleep regulation, reduce motor activity to improve deep sleep, stimulate ACTH and LH levels, and reportedly normalize blood pressure. DSIP can change the serum level of some hormones, such as adrenocorticotropic hormone, somatostatin, serotonin, etc.

Definition

Emideltide or DSIP is a nonapeptide that is found in neurons, peripheral organs, and plasma. This neuropeptide induces mainly delta sleep in mammals. In addition to sleep, the peptide has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.

benefits

Can restore disturbed sleep patterns;Can promote LH and GH release;Can reduce persistent/chronic pain;Can modulate cortisol production.

benefits

Delta sleep-inducing peptide (DSIP), which suppresses excess production of free radicals in the CNS and prevents neuron death during the body’s response to stress. DSIP activates oxidative phosphorylation and increases the resistance of brain neurons to hypoxia in vitro. It decreases the sensitivity of neuron receptors to the excitatory actions of glutamate. Thus, DSIP helps to prevent excitotoxicity, which may underlie its neuroprotective action in cerebral ischemia[1].

References

[1] E. Koplik. “Delta sleep-inducing peptide and Deltaran: Potential approaches to antistress protection.” Neuroscience and Behavioral Physiology 38 1 (2008): 953–957.

Physiological effects

Delta sleep-inducing peptide (DSIP) has several physiological effects in addition to its ability to promote sleep in animals. It is also involved in neuroendocrine regulation and release of anterior pituitary hormones. In rodents and humans, Delta sleep-inducing peptide (DSIP) influence in the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and growth hormone (GH). It also plays a role in the regulation of the circadian rhythms and and can help restore disturbed patterns of sleep.

DSIP Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 255)Suppliers
Supplier Tel Email Country ProdList Advantage
Cellmano Biotech Limited
0551-65326643 18156095617 info@cellmano.com China 1000 58
Wuhan Cell Pharmaceutical Co., Ltd
+86-13129979210 +86-13129979210 sales@cellwh.com China 376 58
Zhuzhou New Peptides Tech Co.,Ltd.
+86-18073326374 +86-18073326374 sales@goodpeptides.com China 56 58
Apextide Co Ltd
+86-15300650552 +86-15300650552 info@apextide.com China 92 58
zhuzhou dingcheng meihei comestic co.,ltd
+8618873369619 dingchengbusiness8@163.com China 260 58
Apeloa production Co.,Limited
+8619933239880 admin@apcl.com.cn China 852 58
Hebei Miaoyin Technology Co.,Ltd
+86-17367732028 +86-17367732028 kathy@hbyinsheng.com China 3512 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810 1022@dideu.com China 3882 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12835 58
Dorne Chemical Technology co. LTD
+86-86-13583358881 +8618560316533 Ethan@dornechem.com China 3105 58

Related Qustion

View Lastest Price from DSIP manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DSIP pictures 2024-11-09 DSIP
62568-57-4
US $1.00 / g 1g 99% 100kg Dorne Chemical Technology co. LTD
DSIP pictures 2024-11-09 DSIP
62568-57-4
US $99.00-66.00 / kg 0.001kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
DSIP  pictures 2024-11-08 DSIP
62568-57-4
US $0.00 / G 1G 99% 20 CONTIDE BIOTECH CO.,LTD
  • DSIP pictures
  • DSIP
    62568-57-4
  • US $1.00 / g
  • 99%
  • Dorne Chemical Technology co. LTD
  • DSIP pictures
  • DSIP
    62568-57-4
  • US $99.00-66.00 / kg
  • 99%
  • HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
  • DSIP  pictures
  • DSIP
    62568-57-4
  • US $0.00 / G
  • 99%
  • CONTIDE BIOTECH CO.,LTD
SLEEP INDUCING PEPTIDE WAGGDASGE TRP-ALA-GLY-GLY-ASN-ALA-SER-GLY-GLU TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU 4H2O DELTA SLEEP INDUCING PEPTIDE DELTA SLEEP-INDUCING PEPTIDE 4H2O DSIP DSIP 4H2O H-TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU-OH EMIDELTIDE TRP-ALA---ASP-ALA-SER--GLU(TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU) DSIP, Sleep inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu L-Trp-L-Ala-Gly-Gly-L-Asp-L-Ala-L-Ser-Gly-Glu-OH L-Trp-L-Ala-Gly-Gly-L-Asp-L-Ala-L-Ser-Gly-L-Glu-OH Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH TRP-ALA-GLY-GLY-ASP-ALA-SER: PO3H2-GLY-GLU [WAGGDA-S: PO3H2-GE] DSIP nonapeptide L-Tryptophyl-L-alanylglycylglycyl-L-alpha-aspartyl-L-alanyl-L-serylglycyl-L-glutamic acid DSIP, EMideltide Delta sleep inducing peptide, ≥97% (HPLC) DSIP/Delta Sleep Inducing Peptide Deltasleep-inducing peptide (rabbit) Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt Etipolypeptide DSIP USP/EP/BP Ftpp/Adipotide DSIP acetate Emideltide (δ-Sleep Inducing Peptide) Delta-Sleep DSIP Lyophilized Powder Delta Sleep Inducing Peptide Acetate δ-Sleep Inducing Peptide acetate 62568-57-4 9431-45-4 C35H48N10O15 Peptide 62568-57-4