ARL 67156
- CAS No.
- 1021868-83-6
- Chemical Name:
- ARL 67156
- Synonyms
- ARL67156 trisodium salt,ARL-67156 trisodium salt
- CBNumber:
- CB64806541
- Molecular Formula:
- C15H25Br2N5NaO12P3
- Molecular Weight:
- 743.11
- MDL Number:
- MFCD08544552
- MOL File:
- 1021868-83-6.mol
ARL 67156 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | A771400 | ARL67156TrisodiumSalt | 1021868-83-6 | 5mg | $920 | 2021-12-16 | Buy |
ChemScene | CS-0026748 | ARL67156(trisodiumsalt) >99.0% | 1021868-83-6 | 1mg | $180 | 2021-12-16 | Buy |
Biosynth Carbosynth | FD145534 | ARL 67156 trisodium hydrate | 1021868-83-6 | 10mg | $325 | 2021-12-16 | Buy |
ApexBio Technology | B6670 | ARL67156trisodiumsalt | 1021868-83-6 | 10mg | $371 | 2021-12-16 | Buy |
ARL 67156 Chemical Properties,Uses,Production
Uses
ARL 67156 Trisodium Salt acts as an ecto-ATPase inhibitor used to aid in distinguishing the function of ATP and its hydrolysis product adenosine in vivo.
Biological Activity
arl 67156 trisodium salt is a selective inhibitor of ecto-atpase. also, fpl 67156 is a weak agonist of p2u-purinoceptors and weak antagonist of p2t- and p2x-purinoceptors [1].ecto-atpase is an integral membrane protein that catalyzes the hydrolysis of extracellular atp to adp and inorganic phosphate.arl 67156 trisodium salt is a selective ecto-atpase inhibitor. in the human blood cell assay, arl 67156 inhibited atp degradation with pic50 value of 4.62. in the rabbit ear artery, arl 67156 30 μm-1 mm) increased the contractile effects of atp and inhibited ecto-atpase with pki value of 5.2 [1]. in the guinea-pig vas deferens, arl 67156 (5-100 μm) significantly increased neurogenic contract response to nerve stimulation in a concentration-dependent way, which was due to potentiation of the action of atp [2]. in hek 293t or cos-7 cells transfected with human npp1, npp3, ntpdase1, 2, 3 or 8, arl 67156 (50-100 μm) competitively inhibited human npp1, ntpdase1 and ntpdase3 with ki values of 12, 11 and 18 μm, respectively [3].in warfarin-induced mineralization rat model, arl67156 inhibited mineralization of the aortic valve/aorta and prevented aortic stenosis by the inhibition of apoptosis. also, arl67156 normalized the level of pakt, which was involved in the survival pathway [4].
storage
Store at -20°C
References
[1]. crack be, pollard ce, beukers mw, et al. pharmacological and biochemical analysis of fpl 67156, a novel, selective inhibitor of ecto-atpase. br j pharmacol, 1995, 114(2): 475-481.
[2]. westfall td, kennedy c, sneddon p. enhancement of sympathetic purinergic neurotransmission in the guinea-pig isolated vas deferens by the novel ecto-atpase inhibitor arl 67156. br j pharmacol, 1996, 117(5): 867-872.
[3]. lévesque sa, lavoie eg, lecka j, et al. specificity of the ecto-atpase inhibitor arl 67156 on human and mouse ectonucleotidases. br j pharmacol, 2007, 152(1): 141-150.
[4]. côté n, el husseini d, pépin a, et al. inhibition of ectonucleotidase with arl67156 prevents the development of calcific aortic valve disease in warfarin-treated rats. eur j pharmacol, 2012, 689(1-3): 139-146.
ARL 67156 Preparation Products And Raw materials
Raw materials
Preparation Products
ARL 67156 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
Wuhan Augda Biotechnology Co., Ltd | 15071299552 | 262933239@qq.com | China | 6637 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29803 | 58 |