Wnt Pathway Inhibitor XII - Calbiochem
- CAS No.
- Chemical Name:
- Wnt Pathway Inhibitor XII - Calbiochem
- Synonyms
- Wnt Pathway Inhibitor XII - Calbiochem
- CBNumber:
- CB64818124
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Wnt Pathway Inhibitor XII - Calbiochem price More Price(1)
Wnt Pathway Inhibitor XII - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) compound that inhibits MAT2A-catalyzed SAM (S-adenosylmethionine) synthesis (IC50 =4.9 μM; [L-Met] = [ATP] = 1 mM, [MAT2A] = 10 μg/mL; 20 min preincubation prior to 30 min reaction) by targeting SAM-binding pocket at the MAT2A dimer interface. Shown to downregulate intracellular SAM level (by 64%; 36 h;10 μM) and Wnt signaling in LS174 CRC (colorectal cancer) cultures and is at least 10-fold more potent than its analogs Pterostilbene (Cat. No. 523310) and Resveratrol (Cat. No. 554325) in inhibiting LS174 proliferation both in vitro (by 70%, 85%, and 90% in 4 d, respectively, with 0.1, 0.3, and 1 μM inhibitor) and in mice in vivo (by 75% on d26; 20 mg/kg/day; i.p.).
Wnt Pathway Inhibitor XII - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
Wnt Pathway Inhibitor XII - Calbiochem Suppliers
Global( 1)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |
Wnt Pathway Inhibitor XII - Calbiochem