ChemicalBook >> CAS DataBase List >>5,15-DIPHENYL-21H,23H-PORPHINE

5,15-DIPHENYL-21H,23H-PORPHINE

5,15-DIPHENYL-21H,23H-PORPHINE structure

CAS No.: 22112-89-6

Chemical Name:: 5,15-DIPHENYL-21H,23H-PORPHINE

Synonyms: 5,15-DPP;5,15-DIPHENYLPORPHINE;5,15-Diphenylporphyrin;5,15-Diphenylporphyrin>5, 15-BIS-(PHENYL)PORPHYRINS;5,15-DIPHENYL-21H,23H-PORPHINE;Stat3 Inhibitor VIII, 5,15-DPP;21H,23H-Porphine, 5,15-diphenyl-;5,15-Bis-(phenyl)-21H,23H-porphyrins;10,20-diphenyl-21,22-dihydroporphyrin

CBNumber:: CB6487713

Molecular Formula:: C32H22N4

Molecular Weight:: 462.54

MDL Number:: MFCD08276335

MOL File:: 22112-89-6.mol

Last updated:2023-06-08 17:06:35

Request For Quotation

5,15-DIPHENYL-21H,23H-PORPHINE Properties

Melting point	>200℃
Boiling point	912.3±65.0 °C(Predicted)
Density	1.285±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	≤2mg/ml in dimethyl formamide
form	Deep blue to deep purple solid
color	Red to Dark blue to Black

SAFETY

Risk and Safety Statements

WGK Germany	3
HS Code	2933.99.8290
HazardClass	IRRITANT

5,15-DIPHENYL-21H,23H-PORPHINE price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D4071	5, 15-DPP	22112-89-6	10mg	$87.5	2024-03-01	Buy
Sigma-Aldrich	573109	STAT3 Inhibitor VIII, 5,15-DPP	22112-89-6	25mg	$140	2023-01-07	Buy
TCI Chemical	D2860	5,15-Diphenylporphyrin >90.0%(HPLC)	22112-89-6	100mg	$333	2024-03-01	Buy
Cayman Chemical	16090	5, 15-DPP ≥95%	22112-89-6	10mg	$32	2024-03-01	Buy
Cayman Chemical	16090	5, 15-DPP ≥95%	22112-89-6	25mg	$109	2024-03-01	Buy

Product number	Packaging	Price	Buy
D4071	10mg	$87.5	Buy
573109	25mg	$140	Buy
D2860	100mg	$333	Buy
16090	10mg	$32	Buy
16090	25mg	$109	Buy

5,15-DIPHENYL-21H,23H-PORPHINE Chemical Properties,Uses,Production

Uses

5,15-Diphenylporphyrin (cas# 22112-89-6) is a useful research chemical.

Biological Activity

5,15-diphenylporphyrin (5,15-dpp) is a selective stat3-sh2 antagonist [1].stat3 is constitutively activated in many human cancers. stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis [2]. aberrant stat3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases [1].

in vitro

5,15-dpp directly bound to stat3 and antagonized the function of stat3-sh2. 5,15-dpp selectively antagonized stat3-sh2 with an ic50 of 0.28 μm over the other sh2-containing proteins stat1 and grb2[1]. the estimated kd values for the 5,15-dpp binding to stat3 was 880 nm. treatment with 5,15-dpp suppressed the dna binding activity of stat3 in a concentration-dependent manner. 5,15-dpp poorly inhibited stat1 with an ic50 of 10 μm and showed no effect grb2 [1].

References

[1] uehara y, mochizuki m, matsuno k, et al. novel high-throughput screening system for identifying stat3–sh2 antagonists[j]. biochemical and biophysical research communications, 2009, 380(3): 627-631.
[2] jing n, tweardy d j. targeting stat3 in cancer therapy[j]. anti-cancer drugs, 2005, 16(6): 601-607.

5,15-DIPHENYL-21H,23H-PORPHINE Preparation Products And Raw materials

Raw materials

Preparation Products

5,15-DIPHENYL-21H,23H-PORPHINE Suppliers

Global( 80)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Boye Science And Technology Development Co., Ltd.	27-81625225 +8615387090420	sumihu@boyechemicals.com	CHINA	215	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58
Aromsyn Co., Ltd.	+86-0571-85585865 +8613336024896	CB@aromsyn.com	China	19185	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Wuhan Boye Science And Technology Development Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Henan Alfa Chemical Co., Ltd	58
Aromsyn Co., Ltd.	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
J & K SCIENTIFIC LTD.	76

22112-89-6(5,15-DIPHENYL-21H,23H-PORPHINE)Related Search:

5,10,15,20-TETRAKIS(4-METHOXYPHENYL)-21H,23H-PORPHINE TPP meso-Tetra(4-carboxyphenyl)porphine 5,10,15,20-TETRAKIS[4-(TRIMETHYLAMMONIO)PHENYL]-21H,23H-PORPHINE TETRA-P-TOSYLATE SALT 4,4',4'',4'''-(PORPHINE-5,10,15,20-TETRAYL)TETRAKIS(BENZENE-SULFONIC ACID) TETRASODIUM SALT DODECAHYDRATE

5,10,15,20-TETRAKIS(4-CARBOXYMETHYLOXYPHENYL)-21H,23H-PORPHINE 5,10,15,20-TETRA-P-TOLYL-21H,23H-PORPHINE 5,10,15,20-TETRAKIS(4-AMINOPHENYL)-21H,23H-PORPHINE 5,10,15,20-TETRAKIS(4-HYDROXYPHENYL)-21H,23H-PORPHINE 5,10,15,20-TETRAKIS(PENTAFLUOROPHENYL)-21H,23H-PORPHINE

TPPS MESO-TETRA(4-SULFONATOPHENYL)PORPHINE DIHYDROCHLORIDE 5 10 15 20-TETRAPHENYL-21H 23H-PORPHINE& 5,10,15,20-TETRAKIS(2,6-DICHLOROPHENYL)PORPHINE 5,10,15,20-TETRA(4-DIMETHYLAMINOPHENYL)PORPHYRIN

MESO-TETRA(4-CARBOXYPHENYL)PORPHINE TETRAMETHYL ESTER RARECHEM AS SA 0022 5 10 15 20-TETRAKIS(4-(ALLYLOXY)PHENYL)&

1of4

5,15-DIPHENYL-21H,23H-PORPHINE 5,15-DIPHENYLPORPHINE 5, 15-BIS-(PHENYL)PORPHYRINS 5,15-Diphenylporphyrin 5,15-Bis-(phenyl)-21H,23H-porphyrins 5,15-DPP Stat3 Inhibitor VIII, 5,15-DPP STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem 10,20-diphenyl-21,22-dihydroporphyrin 5,15-Diphenylporphyrin> 21H,23H-Porphine, 5,15-diphenyl- 22112-89-6 C32H22N4 Porphyrins Biochemistry Porphyrins