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Lonidamine

Description References
Lonidamine
Lonidamine structure
CAS No.
50264-69-2
Chemical Name:
Lonidamine
Synonyms
dica;af1890;lonidamin;Lonidnmine;doridamina;LONIDAMINE;AF-1890:DICA;Lonidamine, >=99%;DICLONDAZOLIC ACID;13iclondazolic Acid
CBNumber:
CB6493965
Molecular Formula:
C15H10Cl2N2O2
Formula Weight:
321.16
MOL File:
50264-69-2.mol

Lonidamine Properties

Melting point:
207-209°C
Boiling point:
537.9±45.0 °C(Predicted)
Density 
1.4835 (rough estimate)
refractive index 
1.6070 (estimate)
storage temp. 
Store at RT
pka
3.00±0.10(Predicted)
InChIKey
WDRYRZXSPDWGEB-UHFFFAOYSA-N
CAS DataBase Reference
50264-69-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H351-H360
Precautionary statements  P201-P281-P308+P313
Hazard Codes  T
Risk Statements  60-22-40
Safety Statements  53-22-36/37/39-45
WGK Germany  3
RTECS  NK7886000
HS Code  29339900
Toxicity LD50 in mice, rats (mg/kg): 900, 1700 orally; 435, 525 i.p. (Heywood)

Lonidamine price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L4900 Lonidamine mitochondrial hexokinase inhibitor 50264-69-2 5mg $125 2018-11-13 Buy
Sigma-Aldrich L4900 Lonidamine mitochondrial hexokinase inhibitor 50264-69-2 25mg $431 2018-11-13 Buy
Cayman Chemical 14640 Lonidamine ≥98% 50264-69-2 5mg $39 2018-11-13 Buy
Cayman Chemical 14640 Lonidamine ≥98% 50264-69-2 10mg $62 2018-11-13 Buy
Cayman Chemical 14640 Lonidamine ≥98% 50264-69-2 50mg $137 2018-11-13 Buy

Lonidamine Chemical Properties,Uses,Production

Description

Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH).

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1477623/
https://en.wikipedia.org/wiki/Lonidamine

Description

Lonidamine is an antineoplastic agent reportedly effective for the treatment of various cancers, including lung, breast, prostate and brain tumors. Its clinical effect appears to be associated with changes in cellular energy metabolism.

Originator

Angelini (Italy)

Uses

contraceptive, spermicidal

Definition

ChEBI: A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively.

brand name

Doridamina

Biological Activity

Anticancer and antispermatogenic agent in vitro and in vivo . Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl - channels in vitro .

Lonidamine Preparation Products And Raw materials

Raw materials

Preparation Products


Lonidamine Suppliers

Global( 160)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21670 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63729 58
Shanghai Synmedia Chemical Co., Ltd. +86 (21) 3868-1880
+86 (21) 3390-8196 sales@synmedia-chem.com China 158 58

View Lastest Price from Lonidamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Lonidamine
50264-69-2
US $1.00 / KG 1G 98% 100KG career henan chemical co

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