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Cefoxitin sodium

Brand Name(s) in US
Cefoxitin sodium
Cefoxitin sodium structure
CAS No.
33564-30-6
Chemical Name:
Cefoxitin sodium
Synonyms
MK-306;MERXIN;BETACEF;FARMOXIN;(6R,7S)-;CENOMYCIN;MEFOXITIN;Mefoxithin;CEFOXITIN NA;cefoxotinsodium
CBNumber:
CB6495398
Molecular Formula:
C16H16N3NaO7S2
Formula Weight:
449.43
MOL File:
33564-30-6.mol

Cefoxitin sodium Properties

Melting point:
>160°C
Boiling point:
843℃
alpha 
25589nm +210° (c = 1 in methanol)
Flash point:
>110°(230°F)
storage temp. 
2-8°C
solubility 
Very soluble in water, sparingly soluble in alcohol.
form 
neat
Water Solubility 
Soluble in water or methanol
CAS DataBase Reference
33564-30-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-42/43
Safety Statements  22-26-36/37-36/37/39
RIDADR  3077
WGK Germany  3
RTECS  XI0330500
HazardClass  9
PackingGroup  III
HS Code  29419000
Toxicity LD50 in mice, rats, dogs (g/kg): 5.10, 8.98, >10.0 i.v. (Takayama)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.

Cefoxitin sodium price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C4786 Cefoxitin sodium salt analytical standard 33564-30-6 1g $199 2018-11-20 Buy
Sigma-Aldrich C4786 Cefoxitin sodium salt analytical standard 33564-30-6 5g $641 2018-11-20 Buy
Alfa Aesar J66800 Cefoxitin sodium, 92.7-97% 33564-30-6 1g $150 2018-11-13 Buy
Alfa Aesar J66800 Cefoxitin sodium, 92.7-97% 33564-30-6 250mg $60.7 2018-11-13 Buy
Cayman Chemical 15990 Cefoxitin (sodium salt) ≥98% 33564-30-6 250mg $50 2018-11-13 Buy

Cefoxitin sodium Chemical Properties,Uses,Production

Brand Name(s) in US

Mefoxin

Chemical Properties

Solid

Uses

Cefoxitin sodium can be used as semi-synthetic antibiotic derived from Cephamycin C, possessing high resistance to β-lactamase inactivation.

Uses

An antibiotic derived from Cephamycin C.

brand name

Mefoxin (Merck).

Clinical Use

Cefoxitin (Mefoxin) is a semisynthetic derivative obtainedby modification of cephamycin C, a 7α-methoxy-substitutedcephalosporin isolated independently from variousStreptomyces by research groups in Japan and the UnitedStates. Although it is less potent than cephalothin againstGram-positive bacteria and cefamandole against most of theEnterobacteriaceae, cefoxitin is effective against certainstrains of Gram-negative bacilli (e.g., E. coli, K. pneumoniae,Providencia spp., S. marcescens, indole-positiveProteus spp., and Bacteroides spp.) that are resistant to thesecephalosporins. It is also effective against penicillin-resistantS. aureus and N. gonorrhoeae. The activity of cefoxitin and cephamycins, in general,against resistant bacterial strains is because of their resistanceto hydrolysis by β-lactamases conferred by the 7α-methoxylsubstituent. Cefoxitin is a potent competitive inhibitor ofmany β-lactamases. It is also a potent inducer of chromosomallymediated β-lactamases. The temptation to exploit the β-lactamase–inhibiting properties of cefoxitin by combining itwith β-lactamase–labile β-lactam antibiotics should be temperedby the possibility of antagonism. In fact, cefoxitin antagonizesthe action of cefamandole against E. cloacae andthat of carbenicillin against P. aeruginosa. Cefoxitin aloneis essentially ineffective against these organisms.
The pharmacokinetic properties of cefoxitin resemblethose of cefamandole. Because its half-life is relativelyshort, cefoxitin must be administered 3 or 4 times daily.Solutions of the sodium salt intended for parenteral administrationare stable for 24 hours at room temperature and 1week if refrigerated. 7α-Methoxyl substitution stabilizes, tosome extent, the β-lactam to alkaline hydrolysis.The principal role of cefoxitin in therapy seems to be forthe treatment of certain anaerobic and mixed aerobic–anaerobicinfections. It is also used to treat gonorrhea caused byβ-lactamase–producing strains. It is classified as a secondgenerationagent because of its spectrum of activity.

Cefoxitin sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Cefoxitin sodium Suppliers

Global( 176)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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Mainchem Co., Ltd.
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+86-0592-6210733 sales@mainchem.com CHINA 32457 55
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Xiamen AmoyChem Co., Ltd
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Shanghai Zheyan Biotech Co., Ltd.
18017610038
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Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
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Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23983 58

View Lastest Price from Cefoxitin sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-22 Cefoxitin sodium
33564-30-6
US $7.00 / mkg 1mkg 99% 100KG career henan chemical co

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