Ceftibuten dihydrate
- CAS No.
- 118081-34-8
- Chemical Name:
- Ceftibuten dihydrate
- Synonyms
- Cetb;Cedax;Seftem;D02121;Sch-39720;Cedax (tn);Cedax-13C3;Seftem (tn);S 7432-13C3;Cedax dihydrate
- CBNumber:
- CB6496825
- Molecular Formula:
- C15H16N4O7S2
- Molecular Weight:
- 428.43
- MDL Number:
- MFCD08141796
- MOL File:
- 118081-34-8.mol
| Melting point | >180°C (dec.) |
|---|---|
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Water (Slightly) |
| form | Solid |
| color | Pale Yellow to Light Orange |
| Stability | Hygroscopic |
| FDA UNII | 62F4443RWP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225 |
| Precautionary statements | P210-P235-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501 |
Ceftibuten dihydrate price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25334 | Ceftibuten (hydrate) ≥98% | 118081-34-8 | 10mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 25334 | Ceftibuten (hydrate) ≥98% | 118081-34-8 | 25mg | $188 | 2024-03-01 | Buy |
| Cayman Chemical | 25334 | Ceftibuten (hydrate) ≥98% | 118081-34-8 | 50mg | $356 | 2024-03-01 | Buy |
| Cayman Chemical | 25334 | Ceftibuten (hydrate) ≥98% | 118081-34-8 | 100mg | $672 | 2024-03-01 | Buy |
| TRC | C244500 | Ceftibuten Hydrate | 118081-34-8 | 2g | $1755 | 2021-12-16 | Buy |
Ceftibuten dihydrate Chemical Properties,Uses,Production
Chemical Properties
Light-Yellow Solid
Uses
Ceftibuten dihydrate, one of the third-generation cephalosporin antibiotic is effectively used in curing several infectious diseases.
Uses
Ceftibuten Dihydrate is used in preparation of Ceftibuten crystal.
Definition
ChEBI: Ceftibuten dihydrate is the dihydrate of ceftibuten. It is used as an orally administered treatment for urinary-tract and respiratory-tract infections. It has a role as an antibacterial drug. It contains a ceftibuten.
Biological Activity
Ceftibuten is an orally bioavailable broad-spectrum cephalosporin antibiotic that inhibits the growth of B. catarrhalis, H. influenzae, pathogenic Neisseria, Streptococcus, penicillin-susceptible S. pneumoniae, and eleven Enterobacteriaceae strains (MICs = 0.25, ≤0.06, ≤0.06, 0.5-1, 4, and ≤0.06-0.5 μg/ml, respectively).1,2 Ceftibuten is also active against E. coli expressing β-lactamase type I, III, and V and K. oxytoca expressing β-lactamase type IV (MICs = 8, 0.25, 0.5, and ≤0.06 μg/ml, respectively) as well as a panel of eight bacterial stains expressing plasmid-encoded extended spectrum β-lactamases, including E. coli CTX-M and K. pneumoniae SHV-2 (MICs = 1 and 0.25 μg/ml, respectively). In vivo, ceftibuten reduces the number of mice killed within 6 days of a K. pneumoniae, E. coli, S. pneumoniae, or S. aureus infection by 50% when administered subcutaneously at doses of 0.125, 2, 1,024, and >512 mg/kg, respectively.3 Formulations containing ceftibuten have been used in the treatment of bacterial infections including bronchitis, pneumonia, and enteritis.
Pharmacokinetics
Ceftibuten Dihydrate is the dihydrate form of ceftibuten, a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Ceftibuten binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Ceftibuten dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 | admin@zhanyaobio.com | China | 2136 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9358 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
View Lastest Price from Ceftibuten dihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-10-19 | Ceftibuten dihydrate
118081-34-8
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-11-13 | Ceftibuten dihydrate
118081-34-8
|
US $10.00 / Kg/Bag | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | |
 |
2021-07-01 | Ceftibuten dihydrate USP/EP/BP
118081-34-8
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Ceftibuten dihydrate
118081-34-8
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Ceftibuten dihydrate
118081-34-8
- US $10.00 / Kg/Bag
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- Ceftibuten dihydrate USP/EP/BP
118081-34-8
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited