3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate monohydrate
![3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate monohydrate Structure](CAS/GIF/313223-04-0.gif)
- CAS No.
- 313223-04-0
- Chemical Name:
- 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate monohydrate
- Synonyms
- 3-((3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO)-&;3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate monohydrate
- CBNumber:
- CB6499008
- Molecular Formula:
- C32H58N2O7S.2H2O
- Molecular Weight:
- 650.913
- MDL Number:
- MFCD21332912
- MOL File:
- 313223-04-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Hazard Codes | T |
| Risk Statements | 61-36/37/38 |
| Safety Statements | 53-26-36/37/39-45 |
| WGK Germany | - |
3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate monohydrate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C439998 | 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonatemonohydrate | 313223-04-0 | 1g | $45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0006459 | 3-((3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO)-1-PROPANESULFONATE HYDRATE 98.00% | 313223-04-0 | 5MG | $750.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0006459 | 3-((3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO)-1-PROPANESULFONATE HYDRATE 98.00% | 313223-04-0 | 50MG | $1686.3 | 2021-12-16 | Buy |
3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate monohydrate Chemical Properties,Uses,Production
Uses
3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate hydrate is a zwitterionic detergent for membrane protein solubilization.
Purification Methods
Triturate this zwitterionic detergent (~50g) with MeOH (200ml), then triturate it with Me2CO (500mL), collect it by vacuum filtration and dry it thoroughly at ~20o. Recrystallise it at 0o from absolute MeOH followed by drying in vacuo to constant weight. It should give one spot with RF 0.32 by TLC on silica gel G in 95% MeOH/5% NH4OH and visualized with iodine vapour; the tertiary amine precursor has RF 0.40. It has low UV absorption (1% in H2O: A280nm is 0.029 and A260nm is 0.035), and the CMC (critical micellar concentration) is 8mM. It is soluble in H2O, MeOH, Me2SO but insoluble in Me2CO, MeCN, hexane, toluene and xylene. [Hjelmeland et al. Anal Biochem 130 72 1983, Matuo et al. Methods Enzymol 198 155 1991.] CHAPSO (3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate betaine) [82473-24-3] M 630.89, m 184-196o, [ ] D +19o (c 2, H2O), pKEst (1) ~<2 (acidic), pKEst(2) ~9 (basic). Dissolve this zwitterionic detergent (~ 60g) in 40% aqueous MeOH and stir it with the mixed-bed ion-exchange resin RG-501 x 8 (100g, Bio-Rad) until the pH of the supernatant is ~ 7. Filter off the resin and evaporate the filtrate to dryness under reduced pressure. Check for homogeneity by TLC on silica gel G in 95% MeOH/5% NH4OH and visualize the spot with iodine vapour (see CHAPS above). [Hjelmeland et al. Anal Biochem 130 72 1983, Matuo et al. Methods Enzymol 198 155 1991.]
3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9823 | 79 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48467 | 58 |
| Supplier | Advantage |
|---|---|
| CONIER CHEM AND PHARMA LIMITED | 58 |
| Aladdin Scientific | 58 |
| Sinopharm Chemical Reagent Co,Ltd. | 79 |
| Energy Chemical | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 58 |