25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
- CAS No.
- 136632-32-1
- Chemical Name:
- 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
- Synonyms
- ALLM (Calpain Inhibitor);ALLM (Ac-Leu-Leu-Met-CHO);N-acetyl-Leu-Leu-methional;Calpain Inhibitor II, ALLM;Calpain Inhibitor II powder;ALLM (Calpain Inhibitor) 95% purity;25 MG CALPAIN INHIBITOR IIRESEARCH GRADE;CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL)
- CBNumber:
- CB6500395
- Molecular Formula:
- C19H35N3O4S1
- Molecular Weight:
- 401.56
- MDL Number:
- MFCD00065506
- MOL File:
- Mol file
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J62491 | Calpain Inhibitor II, 95+% | 136632-32-1 | 25mg | $489 | 2023-06-20 | Buy |
| TRC | A189693 | N-Acetyl-L-leucyl-L-leucyl-L-methional | 136632-32-1 | 2.5mg | $195 | 2021-12-16 | Buy |
| ApexBio Technology | A2603 | CalpainInhibitorII,ALLM | 136632-32-1 | 25mg | $200 | 2021-12-16 | Buy |
| ApexBio Technology | A2603 | CalpainInhibitorII,ALLM | 136632-32-1 | 5mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A2603 | CalpainInhibitorII,ALLM | 136632-32-1 | 10mM(in 1mL DMSO) | $80 | 2021-12-16 | Buy |
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Chemical Properties,Uses,Production
Description
ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki?= 120 nM, calpain II, Ki?= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1?Weak inhibitor of the chymotrypsin-like activity of the proteasome.2?Cell permeable.
Uses
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.
Uses
ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II?in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.
Definition
ChEBI: (2S)-2-acetamido-4-methyl-N-[4-methyl-1-[[4-(methylthio)-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]pentanamide is a peptide.
References
1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins;?J. Enzyme Inhib.,?3?195 2) Vinitsky?et al.?(1992),?Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry,?31?9421
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Preparation Products And Raw materials
Raw materials
Preparation Products
25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| ApexBio Technology LLC | +1-832-696-8203 | info@apexbt.com | United States | 477 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Nanjing Leon Biological Technology Co., Ltd. | 17705183659 | sales@njleonbiotech.com | China | 5504 | 55 |
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