ChemicalBook >> CAS DataBase List >>OLPRINONE HYDROCHLORIDE
OLPRINONE HYDROCHLORIDE
- CAS No.
- 119615-63-3
- Chemical Name:
- OLPRINONE HYDROCHLORIDE
- Synonyms
- e1020;Coretec;OLPRINONE HCL;xo-,monohydrochloride,monohydrate;Olprinone hydrochloride - Loprinone hydrochloride;3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o;1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride;Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
- CBNumber:
- CB6504070
- Molecular Formula:
- C14H11ClN4O
- Molecular Weight:
- 286.72
- MDL Number:
- MFCD01749474
- MOL File:
- 119615-63-3.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:03:00
| Melting point | >3000C |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: ≤4 mg/mL |
| form | solid |
| color | beige |
| FDA UNII | F18B658J56 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | US4201450 | |||||||||
| NFPA 704 |
|
OLPRINONE HYDROCHLORIDE price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O7389 | Olprinone hydrochloride ≥98% (HPLC), solid | 119615-63-3 | 10mg | $214 | 2022-05-15 | Buy |
| Sigma-Aldrich | O7389 | Olprinone hydrochloride ≥98% (HPLC), solid | 119615-63-3 | 50mg | $818 | 2022-05-15 | Buy |
| Cayman Chemical | 28396 | Olprinone (hydrochloride) | 119615-63-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 28396 | Olprinone (hydrochloride) | 119615-63-3 | 25mg | $456 | 2024-03-01 | Buy |
| Cayman Chemical | 28396 | Olprinone (hydrochloride) | 119615-63-3 | 5mg | $122 | 2024-03-01 | Buy |
OLPRINONE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Coatec was launched in Japan for acute cardiac insufficiency in cases resistant to other treatments. There are three related synthetic routes, 5-6 steps each, to loprinone all converging on 1-(imidazo[1,2a]pyridyl-6-yl)-Zpropanone as an advanced intermediate. It is a potent and selective inhibitor of PDE Ⅲ and a long lasting, orally active, positive inotropic agent. The PDE Ⅲ inhibition caused increased levels of CAMP which leads to the positive inotropic effect that was not altered by β or H2-preceptor antagonists. It was 100 times less potent at PDE I and PDE Ⅱ with no Na-K-ATPase activity. Improved hemodynamic parameters with slight changes in heart rate and blood pressure were seen in vivo. It is not mutagenic and its primary metabolite was less active.
Chemical Properties
Off-White Crystalline Powder
Originator
Eisai (Japan)
Uses
Inotropic agent which inhibits cAMP phosphodiesterase. Cardiotonic.
Definition
ChEBI: Olprinone hydrochloride is an organic molecular entity.
brand name
Coatec
OLPRINONE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 56)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9821 | 58 |
| Shanghai Qianyi New Material Co., Ltd. | +8618083322317 | 3391883138@qq.com | China | 878 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
View Lastest Price from OLPRINONE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | OLPRINONE HYDROCHLORIDE
119615-63-3
|
US $7.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- OLPRINONE HYDROCHLORIDE
119615-63-3
- US $7.00 / kg
- 99%
- Career Henan Chemical Co
119615-63-3(OLPRINONE HYDROCHLORIDE)Related Search:
3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o
e1020
xo-,monohydrochloride,monohydrate
OLPRINONE HCL
1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride
Coretec
Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride
Olprinone hydrochloride - Loprinone hydrochloride
119615-63-3
C14H10N4OHCl
Heterocyclic Compounds
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals