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OLPRINONE HYDROCHLORIDE

OLPRINONE HYDROCHLORIDE
OLPRINONE HYDROCHLORIDE structure
CAS No.
119615-63-3
Chemical Name:
OLPRINONE HYDROCHLORIDE
Synonyms
e1020;Coretec;OLPRINONE HCL;xo-,monohydrochloride,monohydrate;Olprinone hydrochloride - Loprinone hydrochloride;3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o;1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride;Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
CBNumber:
CB6504070
Molecular Formula:
C14H10N4O.ClH.H2O
Formula Weight:
304.736
MOL File:
119615-63-3.mol

OLPRINONE HYDROCHLORIDE Properties

Melting point:
>3000C
storage temp. 
2-8°C
solubility 
DMSO: ≤4 mg/mL
form 
solid
color 
beige
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  US4201450

OLPRINONE HYDROCHLORIDE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O7389 Olprinone hydrochloride ≥98% (HPLC), solid 119615-63-3 10mg $187 2018-11-20 Buy
Sigma-Aldrich O7389 Olprinone hydrochloride ≥98% (HPLC), solid 119615-63-3 50mg $716 2018-11-20 Buy

OLPRINONE HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Coatec was launched in Japan for acute cardiac insufficiency in cases resistant to other treatments. There are three related synthetic routes, 5-6 steps each, to loprinone all converging on 1-(imidazo[1,2a]pyridyl-6-yl)-Zpropanone as an advanced intermediate. It is a potent and selective inhibitor of PDE Ⅲ and a long lasting, orally active, positive inotropic agent. The PDE Ⅲ inhibition caused increased levels of CAMP which leads to the positive inotropic effect that was not altered by β or H2-preceptor antagonists. It was 100 times less potent at PDE I and PDE Ⅱ with no Na-K-ATPase activity. Improved hemodynamic parameters with slight changes in heart rate and blood pressure were seen in vivo. It is not mutagenic and its primary metabolite was less active.

Chemical Properties

Off-White Crystalline Powder

Originator

Eisai (Japan)

Uses

Inotropic agent which inhibits cAMP phosphodiesterase. Cardiotonic

brand name

Coatec

OLPRINONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products


OLPRINONE HYDROCHLORIDE Suppliers

Global( 32)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21701 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58
Chongqing Chemdad Co., Ltd +86-13650506873
sales@chemdad.com CHINA 30864 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 chemfun@chemfun.net China 21812 59
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32362 50
Nanjing Norris-Pharm Technology Co., Ltd +86-25-52131256 +86-25-66112885
+86-25-52131256 sales@norris-pharm.com China 8975 55
Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 apisales@chemexpress.com.cn China 7559 61
LETOPHARM LIMITED +86-21-5821 5861
+86-21-5106 2861 sales@letopharm.com China 2391 58

View Lastest Price from OLPRINONE HYDROCHLORIDE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-18 OLPRINONE HYDROCHLORIDE
119615-63-3
US $7.00 / kg 1kg 99% 100kg career henan chemical co

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