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Bosutinib

Bosutinib
Bosutinib structure
CAS No.
380843-75-4
Chemical Name:
Bosutinib
Synonyms
SKI-606;Bsutinib;BOSUTINIB;WAY-173606;Bosutinib(TINIBS );Bosulif(bosutinib);SKI 606 - Bosutinib;Bosutinib ( SKI-606 );Bosutinib for research;Bosutinib ada@tuskwei.com whatsapp
CBNumber:
CB6504575
Molecular Formula:
C26H29Cl2N5O3
Formula Weight:
530.45
MOL File:
380843-75-4.mol

Bosutinib Properties

Melting point:
116-120 ºC
Density 
1.36
storage temp. 
room temp
solubility 
DMSO: ≥15mg/mL
form 
powder
color 
off-white to light brown
InChIKey
PICKMQXYAMDEPF-UHFFFAOYSA-N
CAS DataBase Reference
380843-75-4(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H413
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3
HS Code  29335990

Bosutinib price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0192 Bosutinib ≥98% (HPLC) 380843-75-4 5mg $99.4 2018-11-13 Buy
Cayman Chemical 12030 Bosutinib ≥98% 380843-75-4 5mg $35 2018-11-13 Buy
Cayman Chemical 12030 Bosutinib ≥98% 380843-75-4 10mg $53 2018-11-13 Buy
Cayman Chemical 12030 Bosutinib ≥98% 380843-75-4 50mg $210 2018-11-13 Buy
Cayman Chemical 12030 Bosutinib ≥98% 380843-75-4 100mg $350 2018-11-13 Buy

Bosutinib Chemical Properties,Uses,Production

Description

In September 2012, the US FDA approved bosutinib (also referred to as SKI-607) for the treatment of relapsed or refractory chronicmyeloid leukemia (CML) for patients with resistance or intolerance to prior therapy. The National Cancer Institute estimates that in 2012, 5430 men and women were diagnosed with CML and 610 died of CML. First and second-line therapies for the treatment of CML include imatinib, dasatinib, and nilotinib. Bosutinib, which was initially identified as a Src inhibitor, was later found to be a dual inhibitor of Bcr–Abl (IC50=1.4 nM) and Src family kinases (IC50=3.5 nM). Bosutinib inhibits 16 of 18 imatinib-resistant forms of Bcr–Abl expressed in murine myeloid cell lines. In preclinical in vivo studies, bosutinib at 15 mg/kg administered orally for 5 days caused regression of K562 CML tumors in nude mice and in BaF3 tumors expressing wild type or different imatinib-resistant Bcr–Abl mutants at varying doses. A manufacturing process for the synthesis of bosutinib monohydrate has been reported that employs a key three-component cyclization reaction involving an aniline, a cyanoacetamide intermediate, and triethyl orthoformate followed by cyclization using phosphorous oxytrichloride and an optimized hydration procedure.

Chemical Properties

Pale Yellow Solid

Originator

Wyeth (United States)

Uses

Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.

Uses

A novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells.

Uses

peripheral vasolidator increases cerebral blood flow, potential therapeutic for Altzheimer’s disease, cognitive impairment and dementia

Definition

ChEBI: An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively.

brand name

Bosulif

Bosutinib Preparation Products And Raw materials

Raw materials

Preparation Products


Bosutinib Suppliers

Global( 232)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21671 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
sales@zetchem.com CHINA 2303 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 302 58

View Lastest Price from Bosutinib manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-09-03 Bosutinib
380843-75-4
US $5.00 / KG 1KG 99% 1ton career henan chemical co
2018-07-30 Bosutinib
380843-75-4
US $150.00 / KG 1KG 98% 200KG career henan chemical co

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