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Bosutinib

Bosutinib
Bosutinib structure
CAS No.
380843-75-4
Chemical Name:
Bosutinib
Synonyms
CS-311;SKI-606;Bsutinib;BOSUTINIB;WAY-173606;Bosutinib control;Bosutinib(TINIBS );Bosulif(bosutinib);SKI 606 - Bosutinib;Bosutinib USP/EP/BP
CBNumber:
CB6504575
Molecular Formula:
C26H29Cl2N5O3
Formula Weight:
530.45
MOL File:
380843-75-4.mol

Bosutinib Properties

Melting point:
116-120 ºC
Boiling point:
649.7±55.0 °C(Predicted)
Density 
1.36
storage temp. 
room temp
solubility 
DMSO: ≥15mg/mL
pka
7.63±0.10(Predicted)
form 
powder
color 
off-white to light brown
InChIKey
PICKMQXYAMDEPF-UHFFFAOYSA-N
CAS DataBase Reference
380843-75-4(CAS DataBase Reference)
FDA UNII
5018V4AEZ0
NCI Dictionary of Cancer Terms
bosutinib
NCI Drug Dictionary
bosutinib
ATC code
L01EA04
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H413
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3
HS Code  29335990

Bosutinib price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0192 Bosutinib ≥98% (HPLC) 380843-75-4 5mg $108 2021-03-22 Buy
Cayman Chemical 12030 Bosutinib ≥98% 380843-75-4 5mg $35 2021-03-22 Buy
Cayman Chemical 12030 Bosutinib ≥98% 380843-75-4 10mg $53 2021-03-22 Buy
Cayman Chemical 12030 Bosutinib ≥98% 380843-75-4 50mg $210 2021-03-22 Buy
Cayman Chemical 12030 Bosutinib ≥98% 380843-75-4 100mg $350 2021-03-22 Buy

Bosutinib Chemical Properties,Uses,Production

Description

In September 2012, the US FDA approved bosutinib (also referred to as SKI-607) for the treatment of relapsed or refractory chronicmyeloid leukemia (CML) for patients with resistance or intolerance to prior therapy. The National Cancer Institute estimates that in 2012, 5430 men and women were diagnosed with CML and 610 died of CML. First and second-line therapies for the treatment of CML include imatinib, dasatinib, and nilotinib. Bosutinib, which was initially identified as a Src inhibitor, was later found to be a dual inhibitor of Bcr–Abl (IC50=1.4 nM) and Src family kinases (IC50=3.5 nM). Bosutinib inhibits 16 of 18 imatinib-resistant forms of Bcr–Abl expressed in murine myeloid cell lines. In preclinical in vivo studies, bosutinib at 15 mg/kg administered orally for 5 days caused regression of K562 CML tumors in nude mice and in BaF3 tumors expressing wild type or different imatinib-resistant Bcr–Abl mutants at varying doses. A manufacturing process for the synthesis of bosutinib monohydrate has been reported that employs a key three-component cyclization reaction involving an aniline, a cyanoacetamide intermediate, and triethyl orthoformate followed by cyclization using phosphorous oxytrichloride and an optimized hydration procedure.

Chemical Properties

Pale Yellow Solid

Originator

Wyeth (United States)

Uses

Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.

Uses

A novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells.

Uses

peripheral vasolidator increases cerebral blood flow, potential therapeutic for Altzheimer’s disease, cognitive impairment and dementia

Definition

ChEBI: An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively.

brand name

Bosulif

Bosutinib Preparation Products And Raw materials

Raw materials

Preparation Products


Bosutinib Suppliers

Global( 293)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20892 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com CHINA 2007 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58

View Lastest Price from Bosutinib manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-25 Bosutinib
380843-75-4
US $11.00 / g 1KG 99% 5ton/Month Hebei Yirun Sega Biological Technology Co. Ltd
2021-11-02 Bosutinib
380843-75-4
US $285.00 / g 5g 99% 1000KG Baoji Guokang Healthchem co.,ltd
2021-07-13 Bosutinib
380843-75-4
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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