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Sarpogrelate hydrochloride

Sarpogrelate hydrochloride
Sarpogrelate hydrochloride structure
CAS No.
135159-51-2
Chemical Name:
Sarpogrelate hydrochloride
Synonyms
Anplag;MCI 9042;SARPOGRELATE HCL;Sarpogrelate-D3 HCl;SARPOGRELATE HYDROCHLORIDE;Sarpogrelate hydrochloride, >=99%;Sarpogrelate Hydrochloride intermediate;Butanedioic acid, mono[2-(dimethylamino)-1-[[;Sarpogrelate Hydrochloride (mixture of isomers);4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}pr
CBNumber:
CB6511456
Molecular Formula:
C24H32ClNO6
Formula Weight:
465.96698
MOL File:
135159-51-2.mol

Sarpogrelate hydrochloride Properties

Melting point:
145-148°C
storage temp. 
Desiccate at RT
solubility 
deionized water: ≥5mg/mL
form 
solid
CAS DataBase Reference
135159-51-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,N
Risk Statements  22-50/53
Safety Statements  60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Sarpogrelate hydrochloride price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S5451 Sarpogrelate hydrochloride ≥98% (HPLC) 135159-51-2 5mg $65.9 2018-11-20 Buy
Sigma-Aldrich S5451 Sarpogrelate hydrochloride ≥98% (HPLC) 135159-51-2 25mg $261 2018-11-20 Buy
Cayman Chemical 24194 Sarpogrelate (hydrochloride) ≥98% 135159-51-2 10mg $70 2018-11-19 Buy
Cayman Chemical 24194 Sarpogrelate (hydrochloride) ≥98% 135159-51-2 50mg $245 2018-11-19 Buy
Cayman Chemical 24194 Sarpogrelate (hydrochloride) ≥98% 135159-51-2 100mg $455 2018-11-19 Buy

Sarpogrelate hydrochloride Chemical Properties,Uses,Production

Description

Sarpogrelate hydrochloride, a potent and selective serotonin 5-HT2 receptor antagonist, was launched in Japan as an antithrombotic. It exhibits inhibition of ex vivo platelet aggregation stimulated by serotonin in combination with collagen and suppression of blood vessel constriction mediated by 5-HT2 in vitro. Its antithrombotic effects have been demonstrated in several in vivo experimental models including reduction of the mortality rate in acute pulmonary thromboembolic disease, arterial thrombosis, and peripheral obstructive disease. Sarpogrelate has been shown to be especially useful as an antiplatelet agent for patients with Type 2 diabetes mellitus, in whom 5-HT2mediated amplification of collageninduced platelet aggregation is significantly increased.

Chemical Properties

White Solid

Originator

Mitsubishi Kasei (Japan )

Uses

Sarpogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist ress-induced hemolysis.

brand name

Anplag

Biological Activity

Selective 5-HT 2A receptor antagonist (pK i values are 8.52, 7.43 and 6.57 for 5-HT 2A , 5-HT 2C and 5-HT 2B receptors respectively). Displays selectivity over 5-HT 1 , 5-HT 3 , 5-HT 4 H 1 , H 2 , M 3 , α 1 -adrenergic, α 2 -adrenergic and β -adrenergic receptors. Displays cardioprotective activity in vivo .

Sarpogrelate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Sarpogrelate hydrochloride Suppliers

Global( 136)Suppliers
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Capot Chemical Co.,Ltd.
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